Computerized tumor-infiltrating lymphocytes density score predicts survival of patients with resectable lung adenocarcinoma

A high abundance of tumor-infiltrating lymphocytes (TILs) has a positive impact on the prognosis of patients with lung adenocarcinoma (LUAD). We aimed to develop and validate an artificial intelligence-driven pathological scoring system for assessing TILs on H&E-stained whole-slide images of LUAD. Deep learning-based methods were applied to calculate the densities of lymphocytes in cancer epithelium (DLCE) and cancer stroma (DLCS), and a risk score (WELL score) was built through linear weighting of DLCE and DLCS. Association between WELL score and patient outcome was explored in 793 patients with stage I-III LUAD in four cohorts. WELL score was an independent prognostic factor for overall sur-vival and disease-free survival in the discovery cohort and validation cohorts. The prognostic prediction model-integrated WELL score demonstrated better discrimination performance than the clinicopathologic model in the four cohorts. This artificial intelligence-based workflow and scoring system could promote risk stratification for patients with resectable LUAD.

Automated summary

This study aimed to develop and validate an artificial intelligence-driven pathological scoring system for assessing tumor-infiltrating lymphocytes (TILs) in lung adenocarcinoma (LUAD) patients. The scoring system, based on deep learning methods, showed a correlation between risk score and patient outcomes, outperforming the clinicopathologic model in predicting prognosis.