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Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders

BIOMEDICINES (2022)

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Pierre Garcia et al.

Summary: A key pathological process in Parkinson's disease is the transneuronal spreading of alpha-synuclein, but our study suggests that inclusion formation is not the major driver of neurodegeneration in the early stages. Instead, activated microglia, possibly through oligomeric alpha-syn, may play a key role in this process.

GLIA (2022)

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Review Pharmacology & Pharmacy

Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease

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Summary: This article discusses various approaches to prevent and mitigate alpha-synuclein toxicity in Parkinson's disease, including clearing its aggregates, inhibiting its misfolding and aggregation, reducing its expression level, and enhancing cellular clearance mechanisms. It also discusses the therapeutics in development and the challenges and opportunities in the field.

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Article Multidisciplinary Sciences

Identification of an early-stage Parkinson's disease neuromarker using event-related potentials, brain network analytics and machine-learning

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Summary: This study aims to explore the possibility of developing a biomarker that can differentiate early-stage Parkinson's disease from healthy brain function using a combination of electroencephalography (EEG) event-related potentials (ERPs), Brain Network Analytics (BNA) technology, and machine learning (ML) algorithms.

PLOS ONE (2022)

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Article Nutrition & Dietetics

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease

Giuseppe Caruso et al.

Summary: Cognitive impairment is a significant public health problem associated with normal aging and neurodegenerative disorders. Dietary polyphenols, particularly phenolic acids, play an important role in healthy aging and the prevention of cognitive decline.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models

Anurupa A. Ghosh et al.

Summary: This study evaluated the efficacy of a novel NOX inhibitor in Parkinson's disease (PD) models, and found that the compound improved cell viability, reduced ROS levels, and decreased protein aggregation. Both mouse models treated with the compound showed alleviated motor deficits and reduced protein aggregation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Emerging Role of Phospholipids and Lysophospholipids for Improving Brain Docosahexaenoic Acid as Potential Preventive and Therapeutic Strategies for Neurological Diseases

Mayssa Hachem et al.

Summary: This review focuses on the targeted delivery of DHA to the brain in different lipid forms and suggests future research directions. DHA is essential for neural development, learning, and vision, but deficiencies in cerebral DHA levels have been associated with neurodegenerative diseases. Understanding the role of DHA in brain transport and its beneficial effects in healthy conditions and brain disorders is crucial for the prevention and treatment of neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation

Gaetano Calabrese et al.

Summary: This article discusses the protein-protein interactions of aggregation-prone proteins related to neurodegenerative diseases, highlighting the impact of protein aggregation on cellular functions and the key networks regulating protein aggregation.

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Article Medicine, General & Internal

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind placebo-controlled phase 1a trial

Johannes Levin et al.

Summary: This study evaluated the safety and pharmacokinetics of an orally bioavailable compound anle138b in healthy subjects through a single ascending dose (SAD) and multiple ascending dose (MAD) study. The results showed that anle138b did not cause major adverse events at doses that achieved therapeutic exposure levels in a mouse Parkinson model. These findings suggest the need for further clinical trials of anle138b in patients with synucleinopathies.

EBIOMEDICINE (2022)

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Alpha-Synuclein Aggregation Pathway in Parkinson's Disease: Current Status and Novel Therapeutic Approaches

Marija Vidovic et al.

Summary: Parkinson's disease (PD) is the second-most common neurodegenerative disorder and lacks disease-modifying therapy. Aggregation of alpha-synuclein (alpha-Syn) is closely associated with PD, and current therapeutic strategies primarily focus on targeting alpha-Syn using small molecules and peptides. Other approaches such as gene silencing, cell transplantation, and immunotherapy are also being explored.

CELLS (2022)

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Editorial: Amyloid-Membrane Interactions in Protein Misfolding Disorders: From Basic Mechanisms to Therapy

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Article Pharmacology & Pharmacy

The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field

Yugo Takagi et al.

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Linking glycosphingolipids to Alzheimer's amyloid-ss: extracellular vesicles and functional plant materials

Kohei Yuyama et al.

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GLYCOCONJUGATE JOURNAL (2022)

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Article Clinical Neurology

Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α-Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease

Johan Willem Smit et al.

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MOVEMENT DISORDERS (2022)

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Effects of Dietary Lysophospholipid Inclusion on the Growth Performance, Nutrient Digestibility, Nitrogen Utilization, and Blood Metabolites of Finishing Beef Cattle

Meimei Zhang et al.

Summary: This study evaluated the effects of dietary supplementation with lysophospholipids (LPLs) on the growth performance, nutrient digestibility, and antioxidant status of finishing beef cattle. The results showed that LPL supplementation improved average daily gain, nutrient digestibility, and antioxidant enzyme activity, while reducing cholesterol, triglyceride, and malondialdehyde levels in the blood of the cattle.

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Review Biochemistry & Molecular Biology

The synaptic lipidome in health and disease

Ana Sofia Valles et al.

Summary: Maintaining homeostasis of lipid, protein, and carbohydrate metabolism is crucial for cell functions. The brain, with its high energy demands and unique synaptic features, relies on lipids for structural compartmentalization and synaptic transmission. Imbalances in lipid metabolism during perinatal and late adulthood periods can lead to developmental alterations and neurodegenerative diseases.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2022)

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Article Medicine, Research & Experimental

Lysophospholipids-potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation

Tatsuya Karaki et al.

Summary: This study demonstrates the inhibitory effect of a certain lysophospholipids (LPLs) species extracted from porcine liver decomposition product (PLDP) on alpha-Synuclein (alpha-Syn) aggregation. Lysophosphatidylcholine (LPC) 16:0, LPC18:0, LPC18:1, and lysophosphatidylethanolamine (LPE) 16:0 contained in PLDP-extracted lipids (PEL) were found to strongly inhibit alpha-Syn aggregation. These findings suggest the potential of PLDP-derived LPLs as effective therapeutic agents against alpha-Synucleinopathies.

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Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases

Soonsil Hyun et al.

Summary: Neurodegenerative diseases are characterized by dysfunction of cognition and mobility, often caused by aggregates of misfolded proteins. Recently, targeted protein degradation using small molecules has emerged as a promising new therapeutic approach for these challenging diseases. Various technologies, such as molecular glues, have shown success in degrading disease-related proteins and may hold potential for the treatment of neurodegenerative diseases caused by protein aggregation.

LIFE-BASEL (2021)

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Inhibition of alpha-synuclein aggregation by AM17, a synthetic resveratrol derivative

Edward Chau et al.

Summary: The study found that AM17 can not only inhibit the aggregation of alpha S monomers, but also disaggregate alpha S oligomers and fibrils, independent of copper ions. Resveratrol also showed similar inhibitory effects on alpha S aggregation only in the presence of copper ions.

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Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective

Francois Le Guerroue et al.

Summary: Ubiquitin signaling plays a crucial role in neurodegenerative diseases, primarily associated with degradation signals. Decrease in quality control pathways with age may be a critical factor in the development of neurodegeneration.

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Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

Juan Huang et al.

Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, involve progressive loss of neurons and are common in the elderly. Excessive microglial activation leading to neuroinflammation is closely linked to the onset and progression of these diseases. Natural products like resveratrol show therapeutic potential in modulating microglial polarization and controlling neuroinflammation in the treatment of NDs.

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Advances in Oral Drug Delivery

Mohammed S. Alqahtani et al.

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FRONTIERS IN PHARMACOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information

Nicole Balasco et al.

Summary: The discovery of polypeptide chains' propensity to form amyloid-like aggregates with stability is crucial in understanding neurodegenerative diseases; self-assembling through cross-beta structure can lead to promising biomaterials; successful characterization of amyloid-like assemblies offers new prospects in biomaterial research.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Clinical Neurology

Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats

Nathalie Van den Berge et al.

Summary: Using a rat model, it was found that the propagation of alpha-synuclein pathology from the gut to the brain is more efficient in old rats, resulting in dysfunction of the heart and stomach similar to observations in patients with Parkinson's disease. Age was shown to be a crucial factor for the aggregation and propagation of alpha-synuclein, highlighting the importance of using aged animals in preclinical studies for better understanding of age-dependent interactions.

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Article Biophysics

Strong inhibition of peptide amyloid formation by a fatty acid

Jon Pallbo et al.

Summary: The aggregation of peptides into amyloid fibrils is associated with diseases like Alzheimer's and Parkinson's. In a study examining the influence of the fatty acid linoleic acid on amyloid formation, it was found that even small amounts of this acid could significantly inhibit the fibrillation process of NACore, a model peptide. This inhibitory effect is attributed to the co-association of peptide oligomers and fatty acid aggregates in the early stages of the process, possibly shedding light on similar mechanisms occurring in vivo.

BIOPHYSICAL JOURNAL (2021)

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Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells

Tamotsu Tsukahara et al.

Summary: This study identified the interaction between a metabolically stabilized cPA derivative, 2ccPA, and ANT2 in microglial cells, showing its ability to inhibit apoptosis induced by phenylarsine oxide and improve cell survival.

CELLULAR SIGNALLING (2021)

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Review Biochemistry & Molecular Biology

The role of amyloid oligomers in neurodegenerative pathologies

Cameron Wells et al.

Summary: Neurodegenerative diseases such as AD, PD, HD, and ALS are rooted in the activities of amyloid-like proteins, with monomeric proteins undergoing conformational shifts to facilitate aggregation and formation of solid fibrils. Oligomeric stages are key drivers of neuronal toxicity, and feedback within the pathway results in exponential acceleration of aggregation. The complex protein dynamics contribute to the late onset and accelerating progression of these disorders, affecting cellular interactions and environment. Targeting core elements of pathological progression may hold promise for future therapies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation

Rita Rosado-Ramos et al.

Summary: The study found that fisetin has neuroprotective effects and modulates cellular pathologies related to Parkinson's Disease, reducing the formation of PD hallmark inclusions and increasing dopamine transporter levels.

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Article Clinical Neurology

Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis

Cristina Rosell-Valle et al.

Summary: The chronic modulation of the LPA/LPA receptors-signaling pathway in the brain plays a crucial role in regulating cognition and emotion, particularly through hippocampal-dependent mechanisms. Chronic C18:1 LPA infusion leads to antidepressant effects, improved memory, and enhanced hippocampal neurogenesis, while LPA(1-3) receptor antagonist disrupts memory and induces anxiety and depression-like behaviors.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

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Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

Tsui-Wen Chou et al.

Summary: This study reveals that preformed fibrils of alpha-synuclein induce pathogenic activation of human midbrain astrocytes, involving inflammatory responses, downregulation of phagocytic function, and conferral of neurotoxic activity. These effects are dependent on necroptotic kinases RIPK1 and RIPK3, but do not involve MLKL or necroptosis. The activation of astrocytes occurs through RIPK-dependent activation of NF-kappa B signaling, highlighting new roles for RIP kinase signaling in regulating glial cell biology and neuroinflammation, with implications for Parkinsonian neurodegeneration.

CELL DEATH & DISEASE (2021)

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Effects of Dietary Food Components on Cognitive Functions in Older Adults

Hitoshi Ozawa et al.

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NUTRIENTS (2021)

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Review Clinical Neurology

Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications

Rosie Bell et al.

Summary: This article discusses the features and pathophysiology of Parkinson's disease and related synucleinopathies, emphasizing the potential importance of the dysregulation of lipid homeostasis and alpha-synuclein homeostasis in disease development. It also explores the role of post-translational modifications in modulating the interactions of alpha-synuclein with lipid membranes, and the impact of these advancements on the development of new diagnostic and therapeutic tools.

FRONTIERS IN NEUROLOGY (2021)

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Review Cell Biology

Alpha-Synuclein and Lipids: The Elephant in the Room?

Alessia Sarchione et al.

Summary: Studies have shown that α-syn plays a key role in the pathogenesis of PD and other synucleinopathies, with interactions between α-syn and lipids contributing to misfolding and aggregation. Additionally, α-syn is involved in different steps of synaptic exocytosis. The importance of lipids in PD is highlighted by their impact on α-syn metabolism and modulation, as well as genetic determinants associated with lipid homeostasis and α-syn pathologies.

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Lifeng Zheng et al.

Summary: The study used a high-sensitivity UPLC-MS method to semi-quantitatively measure lipid changes in the mouse cerebral cortex recovering from a stroke, revealing a strong relationship between phosphatidylcholine reduction and lysophosphatidylcholine increase during reperfusion. The data support the role of imbalanced lipid ratios in neuronal damage and inflammatory responses during stroke recovery.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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The Combined Effects of Lysophospholipids against Lipopolysaccharide-induced Inflammation and Oxidative Stress in Microglial Cells

Tamotsu Tsukahara et al.

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Lysophosphatidic Acid Signalling in Nervous System Development and Function

Eric Birgbauer

Summary: Lysophospholipids, particularly lysophosphatidic acid (LPA), play a crucial role in nerve system signaling by activating G protein-coupled receptors (GPCRs) to induce various physiological responses. Aberrant LPA receptor signaling may contribute to neuropathological conditions, with significant clinical implications.

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Structural Optimization of Inhibitors of α-Synuclein Fibril Growth: Affinity to the Fibril End as a Crucial Factor

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The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

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Hiroharu Kamioka et al.

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Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

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An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

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Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

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Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Shigeki Arawaka et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice

Dhavamani Sugasini et al.

SCIENTIFIC REPORTS (2017)

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Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation

Sanja Curcic et al.

SCIENTIFIC REPORTS (2017)

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Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases

Chiara Giacomelli et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Article Biochemistry & Molecular Biology

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

Filsy Samuel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Biochemistry & Molecular Biology

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

Myles R. Minter et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Cell Biology

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity

Zhaoyang Hu et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

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Nutraceuticals against Neurodegeneration: A Mechanistic Insight

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CURRENT NEUROPHARMACOLOGY (2016)

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Review Immunology

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

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IMMUNITY (2016)

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Review Medicine, General & Internal

Alpha-synuclein structure, functions, and interactions

Fatemeh Nouri Emamzadeh

JOURNAL OF RESEARCH IN MEDICAL SCIENCES (2016)

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Article Biochemistry & Molecular Biology

Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson's Disease

Yan Xu et al.

NEUROCHEMICAL RESEARCH (2016)

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Review Neurosciences

Versatile Structures of α-Synuclein

Chuchu Wang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

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Article Agriculture, Dairy & Animal Science

Effect of emulsifier (lysophospholipids) on growth performance, nutrient digestibility and blood profile in weanling pigs

P. Y. Zhao et al.

ANIMAL FEED SCIENCE AND TECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Celine Galvagnion et al.

NATURE CHEMICAL BIOLOGY (2015)

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Article Neurosciences

LYSOPHOSPHATIDYLCHOLINE INCREASES THE NEUROTOXICITY OF ALZHEIMER'S AMYLOID β1-42 PEPTIDE: ROLE OF OLIGOMER FORMATION

A. Md. Sheikh et al.

NEUROSCIENCE (2015)

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Article Multidisciplinary Sciences

Structure based aggregation studies reveal the presence of helix-rich intermediate during alpha-Synuclein aggregation

Dhiman Ghosh et al.

SCIENTIFIC REPORTS (2015)

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Supplementation with complex milk lipids during brain development promotes neuroplasticity without altering myelination or vascular density

Rosamond B. Guillermo et al.

FOOD & NUTRITION RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS

Michiyo Okudaira et al.

JOURNAL OF LIPID RESEARCH (2014)

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Article Chemistry, Multidisciplinary

The Presence of an Air-Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

Silvia Campioni et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Review Neurosciences

Alpha-synuclein and tau: teammates in neurodegeneration?

Simon Moussaud et al.

MOLECULAR NEURODEGENERATION (2014)

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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

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NATURE (2014)

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Plasma phospholipids identify antecedent memory impairment in older adults

Mark Mapstone et al.

NATURE MEDICINE (2014)

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Alpha-synuclein biology in Lewy body diseases

Woojin Scott Kim et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

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Review Biochemistry & Molecular Biology

Novel bioactive glycerol-based lysophospholipids: New data - New insight into their function

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BIOCHIMIE (2013)

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Article Geriatrics & Gerontology

Risk Factors for the Progression of Mild Cognitive Impairment to Dementia

Noll L. Campbell et al.

CLINICS IN GERIATRIC MEDICINE (2013)

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Review Pharmacology & Pharmacy

Insights into the pharmacological relevance of lysophospholipid receptors

Tetsuji Mutoh et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Article Biochemistry & Molecular Biology

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Nunilo Cremades et al.

CELL (2012)

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Article Biochemistry & Molecular Biology

Resveratrol mitigates lipopolysaccharide- and Aß-mediated microglial inflammation by inhibiting the TLR4/NF-?B/STAT signaling cascade

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JOURNAL OF NEUROCHEMISTRY (2012)

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Article Neurosciences

Exosomal cell-to-cell transmission of alpha synuclein oligomers

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MOLECULAR NEURODEGENERATION (2012)

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Protection of Neuroblastoma Neuro2A Cells from Hypoxia-Induced Apoptosis by Cyclic Phosphatidic Acid (cPA)

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PLOS ONE (2012)

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Article Biochemistry & Molecular Biology

Fatty acid transport into the brain: Of fatty acid fables and lipid tails

Ryan W. Mitchell et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2011)

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Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

Katerina E. Paleologou et al.

JOURNAL OF NEUROSCIENCE (2010)

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Review Biochemistry & Molecular Biology

Synthesis of Lysophospholipids

Paola D'Arrigo et al.

MOLECULES (2010)

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Review Biochemistry & Molecular Biology

Metalloproteomics and metal toxicology of alpha-synuclein

Aaron Santner et al.

METALLOMICS (2010)

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Early Diagnosis of Alzheimer's Disease: Is MCI Too Late?

Ronald C. Petersen

CURRENT ALZHEIMER RESEARCH (2009)

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Article Neurosciences

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both α-synuclein and γ-synuclein

Steven L. Senior et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2008)

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Review Neurosciences

Brain foods:: the effects of nutrients on brain function

Fernando Gomez-Pinilla

NATURE REVIEWS NEUROSCIENCE (2008)

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Article Geriatrics & Gerontology

Synuclein activates microglia in a model of Parkinson's disease

Xiaomin Su et al.

NEUROBIOLOGY OF AGING (2008)

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Molecular anatomy of a trafficking organelle

Shigeo Takamori et al.

CELL (2006)

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Article Clinical Neurology

Subtypes of mild cognitive impairment in Parkinson's disease: Progression to dementia

Carmen Cristea Janvin et al.

MOVEMENT DISORDERS (2006)

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Article Biochemical Research Methods

Quantification of lysophosphatidylcholines and phosphatidylcholines using liquid chromatography-tandem mass spectrometry in neonatal serum

Akihiro Takatera et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2006)

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Article Clinical Neurology

How to diagnose dementia with Lewy bodies: State of the art

F Geser et al.

MOVEMENT DISORDERS (2005)

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Article Biochemistry & Molecular Biology

Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease

W Zhang et al.

FASEB JOURNAL (2005)

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Article Multidisciplinary Sciences

Structural characterization of copper(II) binding to α-synuclein:: Insights into the bioinorganic chemistry of Parkinson's disease

RM Rasia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Biochemistry & Molecular Biology

Ubiquitination of α-synuclein

T Nonaka et al.

BIOCHEMISTRY (2005)

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The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study

T Foltynie et al.

BRAIN (2004)

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Article Biochemistry & Molecular Biology

The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils

M Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

NMR of α-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation

CO Fernández et al.

EMBO JOURNAL (2004)

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Article Clinical Neurology

Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease

C Mulder et al.

JOURNAL OF NEURAL TRANSMISSION (2003)

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Article Biochemistry & Molecular Biology

Lipid binding inhibits α-synuclein fibril formation

M Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Cellular polyamines promote the aggregation of α-synuclein

T Antony et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions

M Hasegawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Endocrinology & Metabolism

A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures

N Blondeau et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)

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Article Biochemistry & Molecular Biology

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein

NB Cole et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from α-synuclein in vitro

JA Cohlberg et al.

BIOCHEMISTRY (2002)

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Article Endocrinology & Metabolism

Long-chain polyunsaturated fatty acid accretion in brain

KM Qi et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2002)

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Chaperone-like properties of lysophospholipids

R Kern et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

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Article Biochemistry & Molecular Biology

Membrane binding and self-association of α-synucleins

V Narayanan et al.

BIOCHEMISTRY (2001)

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Review Clinical Neurology

Synucleinopathies - Clinical and pathological implications

JE Galvin et al.

ARCHIVES OF NEUROLOGY (2001)

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α-synuclein membrane interactions and lipid specificity

EJ Jo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Clinical Neurology

α-Synuclein immunoreactivity in dementia with Lewy bodies:: morphological staging and comparison with ubiquitin immunostaining

E Gómez-Tortosa et al.

ACTA NEUROPATHOLOGICA (2000)

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Article Biochemistry & Molecular Biology

Constitutive phosphorylation of the Parkinson's disease associated α-synuclein

M Okochi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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