4.7 Article

Impact of Wound Dressing on Mechanotransduction within Tissues of Chronic Wounds

期刊

BIOMEDICINES
卷 10, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/biomedicines10123080

关键词

chronic wound; wound dressing; mechanotransduction; wound tissue; stiffness; computer modeling; tissue engineering

向作者/读者索取更多资源

Chronic wounds have a significant impact on individuals' health-related quality of life and healthcare systems worldwide. This study investigates the influence of mechanotransduction on the healing process in chronic wounds through the development of three-dimensional tissue models. The results demonstrate that wound dressings with lower stiffness promote force transmission within the wound tissue, with larger dressings exerting higher stresses. These findings highlight the importance of dressing characteristics in promoting healing and provide insights for the design of precision dressings.
Chronic wounds are significant public health problems impacting the health-related quality of individuals' lives (due to disability, decreased productivity, and loss of independence) and an immense economic burden to healthcare systems around the world. In this study, our main objective is to investigate how mechanotransduction can impact the healing process in chronic wounds. We have developed new three-dimensional models of wound tissue to study the distribution of forces within these tissues exerted by wound dressings with different characteristics. The roles of mechanical forces on wound healing have gained significant clinical attention; the application of mechanical forces is expected to influence the physiology of tissue surrounding a wound. We aim to investigate whether the force transmission within wound tissue is impacted by the dressing characteristics and whether this impact may differ with wound tissue's properties. Our results show that wound dressings with lower stiffnesses promote force transmission within a wound tissue. This impact is even more significant on stiffer wound tissues. Furthermore, we show that size of wound dressing alters forces that transmit within the wound tissue where dressings with 9 cm length show higher stresses. The wound tissue stiffening has been associated with healing of a wound. Our results demonstrate that wounds with stiffer tissue experience higher stresses. Taken all together, our findings suggest that low stiffness of wound dressing and its size may be introduced as a criterion to explain parameters predisposing a chronic wound to heal. This study's findings on the role of dressings and tissue characteristics demonstrate that precision dressings are required for wound management and understanding how a dressing impacts mechanotransduction in wound tissue will lead to design of novel dressings promoting healing in chronic wounds.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据