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α1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies
Ugo I. Ekeowa et al.
CLINICAL SCIENCE (2009)
COPD prevalence is increased in lung cancer, independent of age, sex and smoking history
R. P. Young et al.
EUROPEAN RESPIRATORY JOURNAL (2009)
Mechanisms of emphysema in α1-antitrypsin deficiency: molecular and cellular insights
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EUROPEAN RESPIRATORY JOURNAL (2009)
ROLE FOR CATHEPSIN K IN EMPHYSEMA IN SMOKE-EXPOSED GUINEA PIGS
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EXPERIMENTAL LUNG RESEARCH (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Impact of oxidative stress on lung diseases
Hee Sun Park et al.
RESPIROLOGY (2009)
Tobacco Smoke: Involvement of Reactive Oxygen Species and Stable Free Radicals in Mechanisms of Oxidative Damage, Carcinogenesis and Synergistic Effects with Other Respirable Particles
Athanasios Valavanidis et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2009)
A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
Sreekumar G. Pillai et al.
PLOS GENETICS (2009)
Role of miRNA-146a in the regulation of the innate immune response and cancer
Andrew E. Williams et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family
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BIOCHIMIE (2008)
Identification, classification, and expression of RAGE gene splice variants
Barry I. Hudson et al.
FASEB JOURNAL (2008)
Second-hand smoke and human lung cancer
Ahmad Besaratinia et al.
LANCET ONCOLOGY (2008)
Prevalence, severity and underdiagnosis of COPD in the primary care setting
M. Bednarek et al.
THORAX (2008)
Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review
A. R. Bentley et al.
THORAX (2008)
Epigenetic regulation of airway inflammation
Ian M. Adcock et al.
CURRENT OPINION IN IMMUNOLOGY (2007)
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms
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LUNG CANCER (2007)
α-1 Antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis
Irina Petrache et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Neutrophil-derived elastase induces TGF-β1 secretion in human airway smooth muscle via NF-κB pathway
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease
Patryk Szulakowski et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)
Inflammatory cells in the airways in COPD
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THORAX (2006)
Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1
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EUROPEAN RESPIRATORY JOURNAL (2006)
Oxidative stress - Relationship with exercise and training
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SPORTS MEDICINE (2006)
The epigenetic progenitor origin of human cancer
AP Feinberg et al.
NATURE REVIEWS GENETICS (2006)
N-acetylcysteine - passe-partout or much ado about nothing?
ML Aitio
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2006)
DNA methylation and human disease
KD Robertson
NATURE REVIEWS GENETICS (2005)
α1-Antitrypsin and neutrophil elastase imbalance and lung cancer risk
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CHEST (2005)
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer
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JOURNAL OF CLINICAL ONCOLOGY (2005)
Aging of the respiratory system: Impact on pulmonary function tests and adaptation to exertion
JP Janssens
CLINICS IN CHEST MEDICINE (2005)
Reversible histone acetylation and deacetylation mediate genome-wide, promoter-dependent and locus-specific changes in gene expression during plant development
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GENETICS (2005)
Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer
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CLINICAL CANCER RESEARCH (2004)
Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas
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ONCOGENE (2004)
Neutrophil elastase induces mucus cell metaplasia in mouse lung
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)
The nature of small-airway obstruction in chronic obstructive pulmonary disease
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NEW ENGLAND JOURNAL OF MEDICINE (2004)
Chronic obstructive pulmonary disease: molecular and cellular mechanisms
PJ Barnes et al.
EUROPEAN RESPIRATORY JOURNAL (2003)
Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema
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THORAX (2003)
COPD exacerbations: definitions and classifications
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EUROPEAN RESPIRATORY JOURNAL (2003)
Expression of matrix metalloproteinases MMP-9 within the airways in asthma
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RESPIRATORY MEDICINE (2003)
Segregation of receptor and ligand regulates activation of epithelial growth factor receptor
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NATURE (2003)
Matrix metalloproteinase-9 in lung remodeling
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)
Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)
New strains of bacteria and exacerbations of chronic obstructive pulmonary disease
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NEW ENGLAND JOURNAL OF MEDICINE (2002)
Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)
Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes
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HUMAN MOLECULAR GENETICS (2002)
Expression of matrix metalloproteinases in invasive pulmonary adenocarcinoma with bronchioloalveolar component and atypical adenomatous hyperplasia
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AMERICAN JOURNAL OF PATHOLOGY (2001)
3p21, 5q21, and 9p21 allelic deletions are frequently found in normal bronchial cells adjacent to non-small-cell lung cancer, while they are unusual in patients with no evidence of malignancy
J Sanz-Ortega et al.
JOURNAL OF PATHOLOGY (2001)
MMP-2-and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease
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Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems
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IUBMB LIFE (2000)
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
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NATURE GENETICS (2000)
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in bronchial squamous preinvasive lesions
FB Galateau-Salle et al.
HUMAN PATHOLOGY (2000)
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