期刊
BIOMEDICINES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10123027
关键词
IgA nephropathy; gut-associated lymphoid tissue; nasal-associated lymphoid tissue; galactose-deficient IgA1
The dysregulation of the mucosal immune response is closely associated with the pathogenesis of immunoglobulin A nephropathy (IgAN), but it remains unclear how exogenous antigens interact with the mucosal immune system to induce or exacerbate IgAN.
The mucosal immune system, via a dynamic immune network, serves as the first line of defense against exogenous antigens. Mucosal immune system dysregulation is closely associated with the pathogenesis of immunoglobulin A nephropathy (IgAN), as illustrated by IgAN having the clinical feature of gross hematuria, often concurrent with mucosal infections. Notably, previous studies have demonstrated the efficacy of tonsillectomy and found that a targeted-release formulation of budesonide reduced proteinuria in patients with IgAN. However, it remains unclear how exogenous antigens interact with the mucosal immune system to induce or exacerbate IgAN. Thus, in this review, we focus on the dysregulation of mucosal immune response in the pathogenesis of IgAN.
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