Atopic Dermatitis: Clinical Aspects and Unmet Needs

Article Dermatology

Efficacy and safety of dupilumab in pediatric patients with moderate to severe atopic dermatitis: a real-world study

Dan-Yang Yang et al.

Summary: This study assessed the efficacy and safety of Dupilumab in pediatric atopic dermatitis patients. The results showed that Dupilumab could reduce symptoms and improve pruritus, and the frequent adverse events were reversible.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2023)

添加到收藏夹

Letter Dermatology

Dupilumab-associated psoriasis and psoriasiform dermatitis in patients with atopic dermatitis

Fiore Casale et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2022)

添加到收藏夹

Review Allergy

Subtypes of atopic dermatitis: From phenotype to endotype

Yoshiki Tokura et al.

Summary: Atopic dermatitis (AD) is a heterogeneous disorder that can be classified into different types, including the IgE-high, extrinsic subtype and the IgE-normal, intrinsic subtype. Recent research has shown that different populations have different AD subtypes, which differ in immune regulation, skin barrier, and cytokine activation. Therefore, personalized or precision medicine is crucial for the treatment of AD targeting each subtype.

ALLERGOLOGY INTERNATIONAL (2022)

添加到收藏夹

Article Dermatology

Effectiveness and safety of dupilumab in the treatment of atopic dermatitis in children (6-11 years): data from a French multicentre retrospective cohort in daily practice

A. Lasek et al.

Summary: This study evaluated the effectiveness and safety of Dupilumab in the daily practice of children aged 6-11 with moderate-to-severe atopic dermatitis (AD). The results showed a significant decrease in disease severity scores after 3 months of treatment, as well as a lower frequency of adverse events compared to previous trials. However, the administration of injectable form may present challenges in this age group. Overall, Dupilumab is an effective and safe treatment option for children with moderate-to-severe AD.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

添加到收藏夹

Article Pediatrics

Dupilumab Treatment in Children Aged 6-11 Years With Atopic Dermatitis: A Multicentre, Real-Life Study

Maddalena Napolitano et al.

Summary: This study evaluated the effectiveness and safety of dupilumab in the treatment of children aged 6-11 years with atopic dermatitis. The results showed that dupilumab treatment significantly improved disease severity, itching, sleep, and quality of life.

PEDIATRIC DRUGS (2022)

添加到收藏夹

Article Allergy

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

Daphne S. Bakker et al.

Summary: Atopic dermatitis (AD) is highly heterogeneous and can be stratified into biomarker-based endotypes. Through biomarker analysis, we identified four distinct clusters of AD patients, suggesting the potential for personalized therapies based on immunopathology.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Dermatology

Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting

K. S. Thomas et al.

Summary: The HOME VII meeting reached a consensus on establishing core outcome instruments for quality of life, long-term control, and itch intensity in atopic eczema clinical trials.

BRITISH JOURNAL OF DERMATOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A basophil-neuronal axis promotes itch

Fang Wang et al.

Summary: The study identifies that a large proportion of patients with atopic dermatitis (AD) harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. It also shows that in AD-associated inflammation, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares.

CELL (2021)

添加到收藏夹

Article Dermatology

Psoriasiform dermatitis during dupilumab treatment for moderate-to-severe atopic dermatitis in children

Jennifer J. Parker et al.

Summary: Six children between the ages of 4 and 18 with severe atopic dermatitis developed new-onset psoriasiform dermatitis after starting dupilumab treatment, with most experiencing clearance or near clearance with the use of topical corticosteroids. One additional patient had pre-existing psoriasis that was unmasked by dupilumab treatment failure. This suggests that effective treatment with dupilumab for atopic dermatitis may lead to the appearance of psoriasiform lesions by affecting the IL-23/T(H)17 pathway.

PEDIATRIC DERMATOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Atopic Dermatitis Pathogenesis

Jowita Sroka-Tomaszewska et al.

Summary: Atopic dermatitis is a chronic, non-infectious inflammatory skin disease with a complex pathophysiology involving genetic disorders, epidermal barrier defects, immune response alterations, and disruption of skin microbial balance. The disease significantly affects the quality of life of patients and their families, potentially requiring personalized treatment approaches.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Dermatology

Impact of baricitinib in combination with topical steroids on atopic dermatitis symptoms, quality of life and functioning in adult patients with moderate-to-severe atopic dermatitis from the BREEZE-AD7 Phase 3 randomized trial

A. Wollenberg et al.

Summary: Baricitinib plus TCS showed significant improvements in HRQoL, work productivity, and life functioning in patients with moderate-to-severe AD, indicating its potential as an effective treatment option.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis

Thomas Bieber et al.

Summary: The study demonstrated that both 200 mg and 100 mg doses of abrocitinib showed significant efficacy in treating moderate-to-severe atopic dermatitis compared to placebo, with the 200 mg dose being superior to dupilumab in improving itch response. Neither dose of abrocitinib showed significant differences from dupilumab in most other key secondary endpoints at week 16.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Review Immunology

Pruritus as a Distinctive Feature of Type 2 Inflammation

Simone Garcovich et al.

Summary: Research has shown that inflammation and immune responses play an important role in the pathogenesis of chronic pruritic skin diseases, with the release of specific cytokines being the main regulators of chronic itch. Skin diseases such as atopic dermatitis and scabies are associated with the most severe pruritus, while in other conditions, type 2 inflammation is less represented and pruritus is milder.

VACCINES (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial

Kristian Reich et al.

Summary: This study evaluated the efficacy and safety of upadacitinib in combination with topical corticosteroids for moderate-to-severe atopic dermatitis, showing that upadacitinib was more effective and well tolerated compared to placebo.

LANCET (2021)

添加到收藏夹

Article Medicine, General & Internal

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double- blind, randomised controlled phase 3 trials

Emma Guttman-Yassky et al.

Summary: The clinical trials demonstrated that Upadacitinib may be an effective treatment option for moderate-to-severe atopic dermatitis, with a significant improvement in symptoms for most patients within 16 weeks, and both dosages were well tolerated.

LANCET (2021)

添加到收藏夹

Article Dermatology

Treat-to-Target in Atopic Dermatitis: An International Consensus on a Set of Core Decision Points for Systemic Therapies

Marjolein De Bruin-Weller et al.

Summary: This study reached an international consensus on a core set of recommendations for systemic treatment in adults with moderate-to-severe atopic dermatitis through an eDelphi process, covering Guiding Principles, Decision Making, and Outcome Thresholds, providing a framework for shared decision-making.

ACTA DERMATO-VENEREOLOGICA (2021)

添加到收藏夹

Article Dermatology

Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phaseIIItrials

E. L. Simpson et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

添加到收藏夹

Article Allergy

Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice

Yoshinori Yamanishi et al.

ALLERGY (2020)

添加到收藏夹

Article Dermatology

Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis A Randomized Clinical Trial

Jonathan Silverberg et al.

JAMA DERMATOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Atopic dermatitis

Sinéad M Langan et al.

LANCET (2020)

添加到收藏夹

Article Dermatology

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

A. Wollenberg et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

添加到收藏夹

Article Dermatology

Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study

Hyun Jung Lim et al.

ANNALS OF DERMATOLOGY (2020)

添加到收藏夹

Review Dermatology

Adult-Onset Atopic Dermatitis: Characteristics and Management

Paras P. Vakharia et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2019)

添加到收藏夹

Article Biology

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

Carolyn M. Walsh et al.

ELIFE (2019)

添加到收藏夹

Review Allergy

Atopic dermatitis endotypes and implications for targeted therapeutics

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Allergy

Pathophysiology of atopic dermatitis: Clinical implications

Jihyun Kim et al.

ALLERGY AND ASTHMA PROCEEDINGS (2019)

添加到收藏夹

Article Dermatology

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

J. R. Chalmers et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Atopic dermatitis

Stephan Weidinger et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

添加到收藏夹

Article Allergy

The burden of atopic dermatitis

Brian Reed et al.

ALLERGY AND ASTHMA PROCEEDINGS (2018)

添加到收藏夹

Article Allergy

Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis

Judith L. Thijs et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Review Allergy

Atopic Dermatitis in Adults: A Diagnostic Challenge

Silvestre J. F. Salvador et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Article Medicine, General & Internal

Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset

Jee Hee Son et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2017)

添加到收藏夹

Article Medicine, General & Internal

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial

Andrew Blauvelt et al.

LANCET (2017)

添加到收藏夹

Article Dermatology

Involvement of Leukotriene B-4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice

Tsugunobu Andoh et al.

ACTA DERMATO-VENEREOLOGICA (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

添加到收藏夹

Article Dermatology

Typical and atypical clinical appearance of atopic dermatitis

Nanette B. Silverberg

CLINICS IN DERMATOLOGY (2017)

添加到收藏夹

Article Allergy

The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves

Micha Feld et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Article Medicine, General & Internal

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

Diamant Thaci et al.

LANCET (2016)

添加到收藏夹

Article Medicine, General & Internal

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

E. L. Simpson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Review Allergy

Biomarkers for atopic dermatitis: a systematic review and meta-analysis

Judith Thijs et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2015)

添加到收藏夹

Article Dermatology

Substance P activates human eosinophils

Mieke Raap et al.

EXPERIMENTAL DERMATOLOGY (2015)

添加到收藏夹

Letter Dermatology

IL-31 Induces Chemotaxis, Calcium Mobilization, Release of Reactive Oxygen Species, and CCL26 in Eosinophils, Which Are Capable to Release IL-31

Nikola Kunsleben et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

添加到收藏夹

Review Medicine, General & Internal

Diagnosis of Atopic Dermatitis: Mimics, Overlaps, and Complications

Elaine C. Siegfried et al.

JOURNAL OF CLINICAL MEDICINE (2015)

添加到收藏夹

Article Allergy

The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials

Jochen Schmitt et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1

Ferda Cevikbas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

Jochen Schmitt et al.

ALLERGY (2012)

添加到收藏夹

Article Pediatrics

Early eczema and the risk of childhood asthma: a prospective, population-based study

Marit Saunes et al.

BMC PEDIATRICS (2012)

添加到收藏夹

Review Allergy

The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

Tao Zheng et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2011)

添加到收藏夹

Article Allergy

Clinical features of the extrinsic and intrinsic types of adult-onset atopic dermatitis

Kanokvalai Kulthanan et al.

ASIA PACIFIC ALLERGY (2011)

添加到收藏夹

Article Dermatology

Diagnostic criteria for atopic dermatitis: a systematic review

E. E. A. Brenninkmeijer et al.

BRITISH JOURNAL OF DERMATOLOGY (2008)

添加到收藏夹

Review Dermatology

Further exploring the brain-skin connection:: Stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice

Sanja Pavlovic et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

添加到收藏夹

Review Allergy

Risk of developing asthma in young children with atopic eczema: A systematic review

Annelies E. van der Hulst et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

添加到收藏夹

Article Allergy

Prevalences of positive skin test responses to 10 common allergens in the US population: Results from the Third National Health and Nutrition Examination Survey

SJ Arbes et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

添加到收藏夹

Article Allergy

Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects

U Raap et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

添加到收藏夹

Article Allergy

The natural course of atopic dermatitis from birth to age 7 years and the association with asthma

S Illi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

添加到收藏夹

Atopic Dermatitis: Clinical Aspects and Unmet Needs

相关参考文献

导出引文

分享论文