期刊
BIOMEDICINES
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines11020438
关键词
MEG; epilepsy; epilepsy surgery; connectivity; graph theory; focus localization
Epilepsy surgery is an effective treatment option for patients with drug-resistant focal epilepsies, and accurate localization of the epileptogenic zone is essential. This study investigates the relationship between node degree (ND) and the seizure onset zone (SOZ) in resting state magnetoencephalography (MEG) data. The findings suggest that ND in certain frequency bands is significantly related to the SOZ, indicating its potential as a new tool for presurgical evaluation of epilepsy surgery.
Epilepsy surgery is a viable therapy option for patients with pharmacoresistant focal epilepsies. A prerequisite for postoperative seizure freedom is the localization of the epileptogenic zone, e.g., using electro- and magnetoencephalography (EEG/MEG). Evidence shows that resting state MEG contains subtle alterations, which may add information to the workup of epilepsy surgery. Here, we investigate node degree (ND), a graph-theoretical parameter of functional connectivity, in relation to the seizure onset zone (SOZ) determined by invasive EEG (iEEG) in a consecutive series of 50 adult patients. Resting state data were subjected to whole brain, all-to-all connectivity analysis using the imaginary part of coherence. Graphs were described using parcellated ND. SOZ localization was investigated on a lobar and sublobar level. On a lobar level, all frequency bands except alpha showed significantly higher maximal ND (mND) values inside the SOZ compared to outside (ratios 1.11-1.20, alpha 1.02). Area-under-the-curve (AUC) was 0.67-0.78 for all expected alpha (0.44, ns). On a sublobar level, mND inside the SOZ was higher for all frequency bands (1.13-1.38, AUC 0.58-0.78) except gamma (1.02). MEG ND is significantly related to SOZ in delta, theta and beta bands. ND may provide new localization tools for presurgical evaluation of epilepsy surgery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据