☆ 4.7 Review

Genetic Variations of the Vitamin D Metabolic Pathway and COVID-19 Susceptibility and Severity: Current Understanding and Existing Evidence

BIOMEDICINES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Food Science & Technology

Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies

Armin Ebrahimzadeh et al.

Summary: This study conducted a systematic review and meta-analysis to explore the association between vitamin D status and risk of COVID-19 in-hospital mortality. The findings indicate a significant positive relationship between vitamin D deficiency and elevated risk of COVID-19 in-hospital mortality, while each unit increment in serum vitamin D levels was associated with a significant reduction in risk of COVID-19 mortality. Further prospective studies are needed to confirm these findings.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

添加到收藏夹

Article Pediatrics

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

Nancy M. S. Zeidan et al.

Summary: This study investigated whether vitamin D deficiency is a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. The results showed that low vitamin D levels and a specific genotype were significantly associated with increased risk for COVID-19.

PEDIATRIC RESEARCH (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID-19

Tugce Apaydin et al.

Summary: The study showed that vitamin D deficiency is not related to the severity and mortality of COVID-19. However, VDR gene polymorphisms are independently associated with the severity of COVID-19 and the survival of patients.

CLINICAL ENDOCRINOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

Jill Hahn et al.

Summary: Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant). Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega 3 fatty acid placebo).

BMJ-BRITISH MEDICAL JOURNAL (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Vitamin D Regulation of Immune Function

Daniel D. Bikle

Summary: This review examines the mechanisms by which vitamin D and its metabolites regulate the immune system to enhance the body's ability to prevent and/or treat SARS-CoV2 and other respiratory infections. Recent findings suggest that vitamin D deficiency is linked to an increased risk of such infections, while clinical trials show that correcting deficiency reduces the severity of SARS-CoV2 infection. Vitamin D and its metabolites promote innate immune response and restrict excessive inflammation, making them potential targets for prevention and treatment of respiratory infections.

CURRENT OSTEOPOROSIS REPORTS (2022)

添加到收藏夹

Article Pediatrics

Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma

Yong Zhou et al.

Summary: This systematic review investigated the potential relationship between vitamin D receptor (VDR) gene polymorphisms and childhood asthma. The study found that FokI and TaqI polymorphisms were significantly associated with childhood asthma susceptibility, while ApaI and BsmI polymorphisms were not.

FRONTIERS IN PEDIATRICS (2022)

添加到收藏夹

Article Genetics & Heredity

VDR gene polymorphisms are associated with the increased susceptibility to COVID-19 among iranian population: A case-control study

Ali Jafarpoor et al.

Summary: This study investigated the association between host genetic polymorphisms of the VDR and DBP genes and susceptibility to COVID-19 in the Iranian population. The results showed a significant association between the rs2228570 SNP in the VDR gene and COVID-19 susceptibility. However, the polymorphisms of other genes (rs7975232 and rs731236 in the VDR gene, rs7041 in the DBP gene) were not associated with SARS-CoV-2 infection susceptibility.

INTERNATIONAL JOURNAL OF IMMUNOGENETICS (2022)

添加到收藏夹

Article Genetics & Heredity

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Wisam Hasan Madhloom Albu-Mohammed et al.

Summary: Variants in the Vitamin D Receptor gene are associated with the mortality rate of COVID-19, and the impact of these polymorphisms varies among different SARS-CoV-2 variants.

GENES (2022)

添加到收藏夹

Article Medicine, General & Internal

Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection

Mario Giosue Balzanelli et al.

Summary: This article investigates the impact of host genetics on COVID-19 susceptibility and risk. The study identifies certain genes that are associated with disease progression and complications. The findings contribute to a better understanding of the relationship between virus activity and the immune system.

DIAGNOSTICS (2022)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D Endocrine System and COVID-19: Treatment with Calcifediol

Jose Manuel Quesada-Gomez et al.

Summary: The COVID-19 pandemic poses a significant challenge to modern medicine and public health systems. The emergence of new variants with increased infectivity and insufficient global vaccination coverage highlight the need for new therapies or the repurposing of existing drugs. This review explores the potential use of calcifediol, a prohormone of the vitamin D endocrine system, for the treatment of COVID-19 and its association with the disease.

NUTRIENTS (2022)

添加到收藏夹

Article Oncology

Evaluation of 14-day Concentration-time Curves of Vitamin D3 and 25-Hydroxyvitamin D3 in Healthy Adults With Varying Body Mass Index

Nipith Charoenngam et al.

Summary: This study analyzed the concentration-time curves of single-dose oral 25(OH)D3 and vitamin D3 in healthy adults, showing that vitamin D3 took longer to reach peak concentration than 25(OH)D3 in most participants. Individual variations in bioavailability and concentration changes were observed after ingestion of both compounds.

ANTICANCER RESEARCH (2022)

添加到收藏夹

Review Genetics & Heredity

Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management

Nipith Charoenngam et al.

Summary: Hereditary metabolic bone diseases encompass a diverse group of rare diseases with genetic abnormalities in skeletal homeostasis. This review examines 25 selected diseases and genetic variations of 78 genes, covering sclerosing bone disorders, disorders of defective bone mineralization, and disorder of bone matrix and cartilage formation. Advancements in molecular genetics have enabled accurate genetic diagnosis and novel therapeutic strategies for some diseases, but further research is needed for diseases with unclear genetic basis and pathophysiology.

GENES (2022)

添加到收藏夹

Review Critical Care Medicine

Administration of vitamin D and its metabolites in critically ill adult patients: an updated systematic review with meta-analysis of randomized controlled trials

Johannes Menger et al.

Summary: Supplementation of vitamin D in critically ill patients may reduce mortality and shorten ICU length of stay and duration of mechanical ventilation. Parenteral administration might have a greater impact on overall mortality. Heterogeneity and assessed certainty among the studies limit the generalizability of the results.

CRITICAL CARE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Advances in research on ACE2 as a receptor for 2019-nCoV

Jie Wu et al.

Summary: The novel coronavirus (SARS-CoV-2) has caused the global spread of COVID-19, with ACE2 receptor believed to mediate virus entry. Recent studies focus on ACE2 expression changes and virus transmission, shedding light on the pathogenesis of COVID-19.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

添加到收藏夹

Article Virology

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Lutfiye Karcioglu Batur et al.

Summary: The study revealed a significant association between the GT genotype at the rs7041 locus and COVID-19 prevalence and mortality rates, while no significant correlation was found at the rs4588 locus. The GT genotype was found to confer susceptibility to populations in Germany, Mexico, Italy, Czech, and Turkey.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity

Nikola Kotur et al.

Summary: The study found that genetic variants related to vitamin D are associated with severe COVID-19 in adults, and there is variation in allelic frequencies among different populations, suggesting a potential impact on the disease course of COVID-19.

FRONTIERS IN NUTRITION (2021)

添加到收藏夹

Review Public, Environmental & Occupational Health

The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis of observational studies

Mehmet Onur Kaya et al.

Summary: The study found that low serum vitamin D levels may increase the risk of COVID-19 infection and the likelihood of severe disease. Therefore, it is recommended to supplement with vitamin D to prevent COVID-19 and its negative outcomes.

EPIDEMIOLOGY AND HEALTH (2021)

添加到收藏夹

Review Infectious Diseases

Risk factors for Covid-19 severity and fatality: a structured literature review

Dominik Wolff et al.

Summary: A systematic literature review on the risk factors of severe and fatal Covid-19 courses shows that conditions and comorbidities related to poor health status, high age, obesity, diabetes, and hypertension are risk factors for severe and fatal disease courses. Additionally, organ damage and coagulation dysfunctions are associated with severe and fatal courses of the disease.

INFECTION (2021)

添加到收藏夹

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Treatment With 25-Hydroxyvitamin D3 (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-to-Lymphocyte Ratio Marker of Disease Severity in Hospitalized Patients With COVID-19: A Pilot Multicenter, Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

Zhila Maghbooli et al.

Summary: The study demonstrated that oral 25(OH)D3 corrected vitamin D deficiency/insufficiency in COVID-19 patients, leading to improved immune function by increasing lymphocyte counts. This treatment was associated with reduced intensive care unit admission days and mortality.

ENDOCRINE PRACTICE (2021)

添加到收藏夹

Article Infectious Diseases

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

Rasoul Abdollahzadeh et al.

Summary: The study revealed significant associations between VDR gene polymorphisms and clinical data in COVID-19 patients, with different SNPs showing varying levels of impact on symptoms and comorbidities in different patient groups.

INFECTION GENETICS AND EVOLUTION (2021)

添加到收藏夹

Review Nutrition & Dietetics

Oral Vitamin D Therapy in Patients with Psoriasis

Ana Maria Alexandra Stanescu et al.

Summary: Oral vitamin D may be effective as an adjuvant treatment option in psoriasis, but more large-scale studies are needed to determine its efficacy, optimal dose, and adverse effects for patients with psoriasis.

NUTRIENTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vitamin D Receptor (VDR) Gene Polymorphisms and Risk of Coronary Artery Disease (CAD): Systematic Review and Meta-analysis

Samira Tabaei et al.

Summary: This study analyzed the association between VDR gene polymorphisms and CAD risk, finding that FokI and ApaI SNPs were associated with an increased risk of CAD in both Asian and European populations.

BIOCHEMICAL GENETICS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Association of Vitamin D Status With Hospital Morbidity and Mortality in Adult Hospitalized Patients With COVID-19

Nipith Charoenngam et al.

Summary: An independent association was found between vitamin D sufficiency (25(OH)D >= 30 ng/mL) and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity.

ENDOCRINE PRACTICE (2021)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Liana Najjar et al.

Summary: A systematic review and meta-analysis were conducted to assess the association between selected variants affecting 25-hydroxyvitamin D concentrations and T1D risk, revealing no significant correlation. Despite some heterogeneity in one of the genetic variants analyzed, overall results did not show any association with T1D susceptibility. Additionally, subgroup analysis for Caucasians also found no association with T1D.

NUTRIENTS (2021)

添加到收藏夹

Article Nutrition & Dietetics

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Fatme Al-Anouti et al.

Summary: Genetic variations in vitamin D metabolism have been found to be significantly associated with the severity of COVID-19, and further research is needed to clarify their mechanism of action against viral infection. These variants can be used in combination with vaccines to control the spread of SARS-CoV-2, particularly in populations with common vitamin D deficiency.

NUTRIENTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity

Ana Teresa Freitas et al.

Summary: This study in the Portuguese population investigated the prevalence of high impact variants in genes associated with the vitamin D pathways and the genetic background's impact on COVID-19 severity. Results show a relationship between polymorphisms in the GC gene and infection severity, as well as an association between 25(OH)D levels and survival outcomes. These findings suggest a genetic susceptibility for vitamin D deficiency may contribute to higher severity in COVID-19 patients, emphasizing the importance of personalized strategies in viral diseases.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Nutrition & Dietetics

A pilot-randomized, double-blind crossover trial to evaluate the pharmacokinetics of orally administered 25-hydroxyvitamin D3 and vitamin D3 in healthy adults with differing BMI and in adults with intestinal malabsorption

Nipith Charoenngam et al.

Summary: The study aimed to investigate the pharmacokinetics of oral 25-hydroxyvitamin D-3 [25(OH)D-3] and oral vitamin D-3 in healthy participants with different BMI and malabsorptive patients. The results suggest that oral 25(OH)D3 may be a good choice for managing vitamin D deficiency in malabsorptive and obese patients.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Vitamin D and Its Potential Benefit for the COVID-19 Pandemic

Nipith Charoenngam et al.

Summary: Vitamin D is not only important for bone health, but also has beneficial effects on many other organ systems. Experimental studies suggest that vitamin D may play a protective role against the infectivity and severity of COVID-19.

ENDOCRINE PRACTICE (2021)

添加到收藏夹

Review Public, Environmental & Occupational Health

Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Iacopo Chiodini et al.

Summary: This meta-analysis found that vitamin D deficiency is associated with an increased risk of SARS-CoV-2 infection, COVID-19 hospitalization, ICU admission, and mortality. Patients with low vitamin D levels are more susceptible to severe outcomes of COVID-19.

FRONTIERS IN PUBLIC HEALTH (2021)

添加到收藏夹

Review Medicine, General & Internal

Association between vitamin D receptor polymorphisms and acute pancreatitis A protocol for systematic review and meta analysis

Xiaofeng Li et al.

Summary: This meta-analysis aims to summarize the association between BsmI, ApaI, TaqI, and FokI polymorphisms and the risk of acute pancreatitis, with results to be submitted to a peer-reviewed journal for publication.

MEDICINE (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Calcifediol Treatment and COVID-19-Related Outcomes

Xavier Nogues et al.

Summary: The study aimed to elucidate the effect of calcifediol treatment on COVID-19 outcomes. The findings showed that in hospitalized patients with COVID-19, calcifediol treatment significantly reduced ICU admission and mortality.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study

Zhiyong Cui et al.

Summary: The causal associations between serum 25(OH)D concentration and COVID-19 susceptibility, severity, and hospitalization traits were not found in the Mendelian randomization analysis. Sensitivity analyses did not show any signs of horizontal pleiotropy. Therefore, high-quality randomized controlled trials are needed to further explore the role of vitamin D supplementation in the prevention and treatment of COVID-19.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Nutrition & Dietetics

Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study

Juan F. Alcala-Diaz et al.

Summary: A study in five hospitals in the South of Spain found that COVID-19 patients who received oral calcifediol treatment had significantly lower in-hospital mortality during the first 30 days compared to those who did not receive the treatment.

NUTRIENTS (2021)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Nanyang Liu et al.

Summary: This meta-analysis confirmed the association between VDR gene polymorphisms (ApaI, BsmI, and TaqI) and MCI and AD susceptibility. BsmI polymorphism may increase the risk of MCI, ApaI may have a protective effect on MCI, and TaqI may increase the risk of AD.

ADVANCES IN NUTRITION (2021)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Guillaume Butler-Laporte et al.

Summary: This study utilized Mendelian randomization to investigate the relationship between increased vitamin D levels and COVID-19 outcomes. The results consistently showed no evidence supporting an association between genetically predicted vitamin D levels and COVID-19 susceptibility, severity, or hospitalization. Other therapeutic or preventative avenues should be prioritized for COVID-19 randomized controlled trials based on these findings.

PLOS MEDICINE (2021)

添加到收藏夹

Letter Genetics & Heredity

TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

Estela Morales Peralta et al.

Summary: In this study conducted on Cuban patients, it was found that there may be an association between the genotypes of the TaqI polymorphism of the VDR gene and the clinical forms of COVID-19, with the tt genotype potentially increasing the risk of developing symptomatic or severe COVID-19.

EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS (2021)

添加到收藏夹

Article Oncology

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Arash Shirvani et al.

ANTICANCER RESEARCH (2020)

添加到收藏夹

Article Immunology

Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations

Thomas C. Hanff et al.

CLINICAL INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cathelicidin attenuates hyperoxia-induced lung injury by inhibiting oxidative stress in newborn rats

Jiunn-Song Jiang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Editorial Material Infectious Diseases

COVID-19, a pandemic or not?

[Anonymous]

LANCET INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Biology

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

Michael R. Garvin et al.

ELIFE (2020)

添加到收藏夹

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Review Cell Biology

Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing

Ronald M. Evans et al.

CELL METABOLISM (2020)

添加到收藏夹

Review Microbiology

Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19)

Elaheh Kordzadeh-Kermani et al.

FUTURE MICROBIOLOGY (2020)

添加到收藏夹

Review Nutrition & Dietetics

Immunologic Effects of Vitamin D on Human Health and Disease

Nipith Charoenngam et al.

NUTRIENTS (2020)

添加到收藏夹

Review Nutrition & Dietetics

Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk

Ivone F. O. C. Nunes et al.

ADVANCES IN NUTRITION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study

Marta Entrenas Castillo et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

添加到收藏夹

Article Genetics & Heredity

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Jun Long Liao et al.

GENES AND NUTRITION (2020)

添加到收藏夹

Review Medicine, General & Internal

The Effect of Vitamin D Supplementation on Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

Yuanyuan Guan et al.

FRONTIERS IN MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the GC Gene

Clark M. Henderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions

Daniel David Bikle et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D Supplementation and Prevention of Type 2 Diabetes

Anastassios G. Pittas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Disassociation of Vitamin D's Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial

Arash Shirvani et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis

Syed Mohammad et al.

BIOMOLECULES (2019)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

JoAnn E. Manson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Review Endocrinology & Metabolism

The ongoing D-lemma of vitamin D supplementation for nonskeletal health and bone health

Nipith Charoenngam et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia

Laura Weise-Cross et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone

Rabab M. Ali et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

添加到收藏夹

Article Genetics & Heredity

Cdx-2 polymorphism in the vitamin D receptor gene (VDR) marks VDR expression in monocyte/macrophages through VDR promoter methylation

Vanessa Meyer et al.

IMMUNOGENETICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals

Massimo Mezzavilla et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis

Liang Zhang et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Genetics & Heredity

Vitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis

Marina Laplana et al.

GENE (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability

Marc Vila Cuenca et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

添加到收藏夹

Article Clinical Neurology

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

Laurie McLaughlin et al.

JOURNAL OF NEUROLOGY (2018)

添加到收藏夹

Review Medicine, General & Internal

Efficacy of vitamin D in treatment of inflammatory bowel disease A meta-analysis

Jinzhong Li et al.

MEDICINE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cathelicidins display conserved direct antiviral activity towards rhinovirus

Filipa Henderson Sousa et al.

PEPTIDES (2017)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Adrian R. Martineau et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Adrian R. Martineau et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

添加到收藏夹

Article Immunology

Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway

Vanessa Meyer et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

ASSOCIATION BETWEEN TWO COMMON POLYMORPHISMS OF VITAMIN D BINDING PROTEIN AND THE RISK OF CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY

Shahriar Tarighi et al.

JOURNAL OF MEDICAL BIOCHEMISTRY (2017)

添加到收藏夹

Review Medical Laboratory Technology

Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer

Surojit Sarkar et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

Anika V. Prabhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

添加到收藏夹

Article Critical Care Medicine

Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial

Sadeq A. Quraishi et al.

CRITICAL CARE MEDICINE (2015)

添加到收藏夹

Review Endocrinology & Metabolism

The PTH-Vitamin D-FGF23 axis

Jenny E. Blau et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2015)

添加到收藏夹

Review Immunology

Association between vitamin D receptor polymorphisms and multiple sclerosis: systematic review and meta-analysis of case-control studies

Kalthoum Tizaoui et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium

Christopher C. Gibson et al.

PLOS ONE (2015)

添加到收藏夹

Review Public, Environmental & Occupational Health

Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D

Cedric F. Garland et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Pharmacokinetics of oral vitamin D3 and calcifediol

Alexander Jetter et al.

BONE (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Vitamin D Is a Regulator of Endothelial Nitric Oxide Synthase and Arterial Stiffness in Mice

Olena Andrukhova et al.

MOLECULAR ENDOCRINOLOGY (2014)

添加到收藏夹

Review Pediatrics

Vitamin D Receptor (VDR) Polymorphisms and Severe RSV Bronchiolitis: A Systematic Review and Meta-Analysis

J. Dayre McNally et al.

PEDIATRIC PULMONOLOGY (2014)

添加到收藏夹

Article Urology & Nephrology

1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis

Galina Nesterova et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-analysis

Le-Ning Xue et al.

INFLAMMATORY BOWEL DISEASES (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

Shweta Tripathi et al.

JOURNAL OF GENERAL VIROLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin D status: Multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient

Robyn M. Lucas et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D for Health: A Global Perspective

Arash Hossein-nezhad et al.

MAYO CLINIC PROCEEDINGS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

Arash Hossein-nezhad et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D3 Supplementation

Carsten Carlberg et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo

Jinge G. Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Review Immunology

The vitamin D receptor and T cell function

Martin Kongsbak et al.

FRONTIERS IN IMMUNOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D

Glenville Jones et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vitamin D and cancer: a review of molecular mechanisms

James C. Fleet et al.

BIOCHEMICAL JOURNAL (2012)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Role of Vitamin D in Insulin Resistance

Chih-Chien Sung et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

添加到收藏夹

Article Nutrition & Dietetics

Symposium 3: Vitamin D and immune function: from pregnancy to adolescence Vitamin D and immune function: an overview

Martin Hewison

PROCEEDINGS OF THE NUTRITION SOCIETY (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Vitamin D and the skin: Physiology and pathophysiology

Daniel D. Bikle

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2012)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D and the Immune System

Cynthia Aranow

JOURNAL OF INVESTIGATIVE MEDICINE (2011)

添加到收藏夹

Review Cell Biology

Vitamin D and diabetes: Its importance for beta cell and immune function

Heidi Wolden-Kirk et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

Peter G. Barlow et al.

PLOS ONE (2011)

添加到收藏夹

Article Endocrinology & Metabolism

The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3

J. Wesley Pike et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2010)

添加到收藏夹

Editorial Material Medicine, General & Internal

Genetic and environmental determinants of vitamin D status

Roger Bouillon

LANCET (2010)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D Deficiency in Adults: When to Test and How to Treat

Kurt A. Kennel et al.

MAYO CLINIC PROCEEDINGS (2010)

添加到收藏夹

Review Microbiology

The vitamin D-antimicrobial peptide pathway and its role in protection against infection

Adrian F. Gombart

FUTURE MICROBIOLOGY (2009)

添加到收藏夹

Article Immunology

Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

Jun Tang et al.

JOURNAL OF IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Regulatory role of promoter and 3′ UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis

P. Selvaraj et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2008)

添加到收藏夹

Article Immunology

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

Sif Hansdottir et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹

Review Endocrinology & Metabolism

Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

John S. Adams et al.

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2008)

添加到收藏夹

Article Immunology

Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation

Sheng Chen et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Review Medicine, General & Internal

Vitamin D deficiency

Michael F. Holick

NEW ENGLAND JOURNAL OF MEDICINE (2007)

添加到收藏夹

Article Immunology

The vitamin D receptor gene FokI polymorphism:: Functional impact on the immune system

Evelyne van Etten et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

1α,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells

A Boonstra et al.

JOURNAL OF IMMUNOLOGY (2001)

添加到收藏夹

Article Critical Care Medicine

Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells

JA Erukhimov et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.