PET/CT with 18F-choline or 18F-FDG in Hepatocellular Carcinoma Submitted to 90Y-TARE: A Real-World Study

Article Radiology, Nuclear Medicine & Medical Imaging

Utility of Early Posttreatment PET/CT Evaluation Using FDG or 18F-FCH to Predict Response to 90Y Radioembolization in Patients With Hepatocellular Carcinoma

Edouard Reizine et al.

Summary: The purpose of this study is to evaluate the utility of early post-treatment evaluation by PET/CT using FDG or F-18-FCH to predict 6-month treatment response and survival after TARE in patients with HCC.

AMERICAN JOURNAL OF ROENTGENOLOGY (2022)

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Review Oncology

Intraarterial Therapies for the Management of Hepatocellular Carcinoma

Tushar Garg et al.

Summary: Hepatocellular carcinoma is the most common liver cancer, and transarterial therapies play a crucial role in patient management. This article reviews the different types of transarterial therapies and discusses the pre-procedural, intra-procedural, and post-procedural patient management, along with a review of the literature.

CANCERS (2022)

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Review Medicine, General & Internal

18F-FDG /18F-Choline Dual-Tracer PET Behavior and Tumor Differentiation in HepatoCellular Carcinoma. A Systematic Review

Jerome Ghidaglia et al.

Summary: Dual 18F-FDG/18F-Choline PET can assess the degree of differentiation in HCC tumors. However, there is a high overlap in the PET behavior of 18F-FDG/18F-Choline between well-differentiated and less-differentiated HCC, making it challenging to characterize tumors based on this PET combination alone. Further studies are needed to improve our understanding of radiotracer behavior in the field of HCC and enhance the usefulness of PET imaging in the clinical decision process.

FRONTIERS IN MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

Trans-arterial Radioembolization Dosimetry in 2022

Etienne Garin et al.

Summary: This review presents the dosimetry and radiobiology concepts of trans-arterial radioembolization, and provides the main clinical dosimetry results for hepatocellular carcinoma and metastases of colorectal carcinoma. The use of different microspheres or isotopes leads to different radiobiology effects, and personalized dosimetry has a significant impact on response and overall survival.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)

Thomas Helmberger et al.

Summary: The CIRT study analyzed 1027 patients and found that a majority of treatment intentions were palliative. Various malignant tumors had different median overall survival rates, and significant prognostic factors for survival included the presence of ascites, cirrhosis, extra-hepatic disease, patient performance status (ECOG), number of chemotherapy lines prior to TARE, and tumor burden.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Safety and efficacy of repeat Y90 radioembolization to the same hepatic arterial territory

Wali Badar et al.

Summary: Repeat TARE with glass microspheres is an effective and safe treatment strategy for disease management in patients with residual or recurrent disease to the similar hepatic arterial territories without any major treatment related toxicity. This study demonstrates that repeat treatment to the same hepatic arterial territory is as safe as single treatment to the same territory.

BRITISH JOURNAL OF RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

18F-choline PET-computed tomography for the prediction of early treatment responses to transarterial radioembolization in patients with hepatocellular carcinoma

Godefroy Aujay et al.

Summary: This study demonstrated that changes in metabolic parameters measured by F-18-fluorocholine PET/CT could predict the response to TARE treatment in HCC patients, with post-treatment inflammation playing a crucial role in prediction.

NUCLEAR MEDICINE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

A new in vitro model applied 90Y microspheres to study the effects of low dose beta radiation on colorectal cancer cell line in various oxygenation conditions

Piotr Piasecki et al.

Summary: A new in vitro model was proposed to assess the effects of Y-90-microspheres derived low-dose beta radiation on colorectal cancer cells under various oxygenation conditions. The study found that hypoxia induced a higher resistance to radiation, and doses below 70 Gy could reduce colorectal cancer cell proliferation in vitro. This model could be useful for evaluating Y-90 radioembolization effects at the micro-scale.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Improving Outcomes of Tyrosine Kinase Inhibitors in Hepatocellular Carcinoma: New Data and Ongoing Trials

Lisha Mou et al.

Summary: Targeted therapies like TKIs are crucial for advanced HCC treatment, with combination therapies involving immune checkpoint inhibitors showing promise. Nanoparticle-based TKI delivery techniques are also expected to enhance treatment efficacy, making it more efficient.

FRONTIERS IN ONCOLOGY (2021)

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Review Gastroenterology & Hepatology

Advances in immunotherapy for hepatocellular carcinoma

Bruno Sangro et al.

Summary: Immunotherapeutic interventions have shown effectiveness in the treatment of hepatocellular carcinoma. Checkpoint inhibitors have demonstrated strong anti-tumor activity, but other immune strategies have not yet shown consistent clinical activity. Advancing treatment to earlier stages, discovering predictive biomarkers, and exploring effective combinatorial approaches are key challenges in HCC immunotherapy.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Engineering, Biomedical

Recent advances in PET probes for hepatocellular carcinoma characterization

Luca Filippi et al.

EXPERT REVIEW OF MEDICAL DEVICES (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Radioembolization with 90Y glass microspheres for hepatocellular carcinoma: significance of pretreatment 11C-acetate and 18F-FDG PET/CT and posttreatment 90Y PET/CT in individualized dose prescription

Chi Lai Ho et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2018)

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Article Oncology

Yttrium-90 resin microspheres and their use in the treatment of intrahepatic cholangiocarcinoma

Luca Filippi et al.

FUTURE ONCOLOGY (2018)

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Article Gastroenterology & Hepatology

Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma

Julia Chalaye et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Peter R. Galle et al.

JOURNAL OF HEPATOLOGY (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

Imaging Evaluation Following Y-90 Radioembolization of Liver Tumors: What Radiologists Should Know

Ijin Joo et al.

KOREAN JOURNAL OF RADIOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diffusion-weighted MRI Is Superior to PET/CT in Predicting Survival of Patients Undergoing 90Y Radioembolization of Hepatic Metastases

Alexandra Barabasch et al.

RADIOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Decrease in total lesion glycolysis and survival after yttrium-90-radioembolization in poorly differentiated hepatocellular carcinoma with portal vein tumour thrombosis

Luca Filippi et al.

NUCLEAR MEDICINE COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician

Lawrence Blonde et al.

ADVANCES IN THERAPY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

PERCIST in Perspective

Joo Hyun O et al.

NUCLEAR MEDICINE AND MOLECULAR IMAGING (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Phantom validation of quantitative Y-90 PET/CT-based dosimetry in liver radioembolization

Marco D'Arienzo et al.

EJNMMI RESEARCH (2017)

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Review Oncology

Trans-arterial radioembolization in intermediate-advanced hepatocellular carcinoma: systematic review and meta-analyses

Carla Rognoni et al.

ONCOTARGET (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluating Treatment Response of Radioembolization in Intermediate-Stage Hepatocellular Carcinoma Patients Using 18F-Fluoroethylcholine PET/CT

Markus Hartenbach et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0

Ronald Boellaard et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

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Review Gastroenterology & Hepatology

Diagnostic role of radiolabelled choline PET or PET/CT in hepatocellular carcinoma: a systematic review and meta-analysis

Francesco Bertagna et al.

HEPATOLOGY INTERNATIONAL (2014)

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Review Radiology, Nuclear Medicine & Medical Imaging

Use of choline PET for studying hepatocellular carcinoma

Jean-Noel Talbot et al.

CLINICAL AND TRANSLATIONAL IMAGING (2014)

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Review Oncology

Transarterial radioembolization using yttrium-90 microspheres in the treatment of hepatocellular carcinoma: a review on clinical utility and developments

Alberta Cappelli et al.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2014)

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Article Gastroenterology & Hepatology

Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma

Rita Golfieri et al.

JOURNAL OF HEPATOLOGY (2013)

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Article Oncology

PATIENT SELECTION AND ACTIVITY PLANNING GUIDE FOR SELECTIVE INTERNAL RADIOTHERAPY WITH YTTRIUM-90 RESIN MICROSPHERES

Wan-Yee Lau et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography

JD Lee et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2004)

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PET/CT with 18F-choline or 18F-FDG in Hepatocellular Carcinoma Submitted to 90Y-TARE: A Real-World Study

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