期刊
BIOMEDICINES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10123079
关键词
signal-transducing adaptor protein-2 (STAP-2); signal transduction; immune response; T cells; T cell antigen receptor (TCR)
资金
- JSPS KAKENHI
- [19H03364]
- [21K08451]
Adaptor molecules play a crucial role in signal transduction in immune cells and are potential therapeutic targets for T cell-mediated immune disorders. STAP-2, a member of the STAP family, is involved in T cell activation and autoimmune diseases. Understanding the impact of STAP-2 on T cell-mediated inflammation and immune diseases can aid in the development of novel therapeutic strategies.
Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell development and activation following T cell receptor (TCR) aggregation, suggesting that adaptor molecules are good therapeutic targets for T cell-mediated immune disorders, such as autoimmune diseases and allergies. Signal-transducing adaptor protein (STAP)-2 is a member of the STAP family of adaptor proteins. STAP-2 functions as a scaffold for various intracellular proteins, including BRK, signal transducer, and activator of transcription (STAT)3, STAT5, and myeloid differentiation primary response protein (MyD88). In T cells, STAP-2 is involved in stromal cell-derived factor (SDF)-1 alpha-induced migration, integrin-dependent cell adhesion, and Fas-mediated apoptosis. We previously reported the critical function of STAP-2 in TCR-mediated T cell activation and T cell-mediated autoimmune diseases. Here, we review how STAP-2 affects the pathogenesis of T cell-mediated inflammation and immune diseases in order to develop novel STAP-2-targeting therapeutic strategies.
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