期刊
BIOMEDICINES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10123265
关键词
breast cancer; glycomics; biochemical markers
资金
- Croatian Ministry of Science and Education
- [IP13-MEFOS-2022]
This review summarizes the important information about glycosylation characteristics in breast cancer cells and discusses how glycoproteins and enzymes involved in glycosylation could serve as more precise biomarkers and therapeutic targets.
Although we are lately witnessing major improvements in breast cancer treatment and patient outcomes, there is still a significant proportion of patients not receiving efficient therapy. More precisely, patients with triple-negative breast cancer or any type of metastatic disease. Currently available prognostic and therapeutic biomarkers are not always applicable and oftentimes lack precision. The science of glycans is a relatively new scientific approach to better characterize malignant transformation and tumor progression. In this review, we summarize the most important information about glycosylation characteristics in breast cancer cells and how different glycoproteins and enzymes involved in glycosylation could serve as more precise biomarkers, as well as new therapeutic targets.
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