期刊
BIOMEDICINES
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines11010099
关键词
autoimmunity; immunodeficiency; immunosurveillance; TNF-alpha inhibitors; calcineurin inhibitors; mTOR inhibitors; IMPDH inhibitors; purine antagonists; transplant; cancer progression; immune checkpoint inhibitors
This review examines the complex interactions between immune system activation and deactivation and the development of malignant tumors, as well as the link between autoimmunity and cancer rates. Furthermore, it focuses on the main classes of immune inhibitor therapy used in transplant patients and in autoimmune diseases, such as TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists, and IMPDH inhibitors.
Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors.
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