4.7 Review

Emerging precision neoadjuvant systemic therapy for patients with resectable non-small cell lung cancer: current status and perspectives

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Review Oncology

PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis

Hongsheng Deng et al.

Summary: To date, there is no approved biomarker for predicting pathological response in neoadjuvant PD-(L)1 blockades treated early-stage NSCLC. However, high PD-L1 expression and high TMB are associated with higher rates of MPR and pCR. The cutoff value of 50% demonstrates better prediction efficacy for MPR than 1%.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

Editorial Material Oncology

VP3-2022: Pembrolizumab (pembro) versus placebo for early-stage non-small cell lung cancer (NSCLC) following complete resection and adjuvant chemotherapy (chemo) when indicated: Randomized, triple-blind, phase III EORTC-1416-LCG/ETOP 8-15 e PEARLS/KEYNOTE-091 study

L. Paz-Ares et al.

Summary: This study evaluated the efficacy of adjuvant pembrolizumab compared to placebo in patients with completely resected early-stage non-small cell lung cancer. The results showed that adjuvant pembrolizumab significantly improved disease-free survival in the overall population, but did not reach statistical significance in the PD-L1 expression >= 50% population. Adverse events were more common in the pembrolizumab group compared to the placebo group.

ANNALS OF ONCOLOGY (2022)

Letter Oncology

Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients

Zhen Zhou et al.

Summary: This study investigated the genetic changes between NSCLC patients with different responses to neoadjuvant immunotherapy and discovered potential biomarkers that can predict therapeutic outcomes. The findings suggest that HR pathway gene status could serve as novel indicators for guiding treatment decisions in NSCLC patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Oncology

Non-Small Cell Lung Cancer, Version 3.2022

David S. Ettinger et al.

Summary: This passage introduces the recommended management for non-small cell lung cancer (NSCLC) in the NCCN Clinical Practice Guidelines, with a focus on targeted therapies for patients with metastatic NSCLC and actionable mutations.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2022)

Review Radiology, Nuclear Medicine & Medical Imaging

Total-body PET/CT-First Clinical Experiences and Future Perspectives

Quinn Kwan-Tai Ng et al.

Summary: The development of total-body PET technology has greatly improved sensitivity and lesion detection, providing several benefits in clinical applications. However, there are also limitations and challenges that need to be addressed.

SEMINARS IN NUCLEAR MEDICINE (2022)

Article Oncology

Cancer treatment and survivorship statistics, 2022

Kimberly D. Miller et al.

Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Oncology

Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non-Small-Cell Lung Cancer (NADIM phase II trial)

Mariano Provencio et al.

Summary: Neoadjuvant chemotherapy plus nivolumab demonstrates effectiveness in resectable non-small cell lung cancer. Pretreatment ctDNA levels significantly correlate with survival outcomes and outperform radiologic assessments in predicting survival.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB-IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial

Mary O'Brien et al.

Summary: This study evaluated the use of Pembrolizumab as adjuvant therapy for completely resected stage IB-IIIA NSCLC. The results showed that Pembrolizumab significantly improved disease-free survival in both the overall population and the PD-L1 TPS of 50% or greater population.

LANCET ONCOLOGY (2022)

Article Oncology

Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

Chao Zhang et al.

Summary: Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, neoadjuvant immunotherapy may be clinically valuable for resectable localized oncogene-mutant NSCLC, especially for EGFR-mutant NSCLC.

NPJ PRECISION ONCOLOGY (2022)

Article Oncology

Early changes in the circulating T cells are associated with clinical outcomes after PD-L1 blockade by durvalumab in advanced NSCLC patients

Elliot Naidus et al.

Summary: Durvalumab, an immune checkpoint inhibitor targeting PD-L1, shows promising results in NSCLC patients by increasing the diversity of TCR repertoire, leading to improved overall survival. Patients with greater TCR cluster size and increased diversity after 15 days of durvalumab treatment tend to have longer overall survival, highlighting the potential of early TCR repertoire diversification as a predictive marker for improved survival outcomes in NSCLC patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial

Luis Paz-Ares et al.

Summary: The combination of first-line nivolumab plus ipilimumab with a limited course of chemotherapy showed a significant improvement in overall survival for patients with advanced non-small-cell lung cancer, supporting it as a new treatment option for this patient population.

LANCET ONCOLOGY (2021)

Review Oncology

Emerging biomarkers for neoadjuvant immune checkpoint inhibitors in operable non-small cell lung cancer

Monika Pradhan et al.

Summary: The advent of immune checkpoint inhibitors has significantly changed the treatment of patients with locally advanced to resectable and metastatic non-small cell lung cancer. While early results of neoadjuvant ICIs in early-stage NSCLC are promising, further research is needed to explore efficacy, resistance mechanisms, and biomarkers for predicting clinical benefit.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Clinical Impact of Adherence to NCCN Guidelines for Biomarker Testing and First-Line Treatment in Advanced Non-Small Cell Lung Cancer (aNSCLC) Using Real-World Electronic Health Record Data

Ani John et al.

Summary: The study found improved clinical outcomes in patients who were adherent to NCCN-recommended biomarker testing and first-line therapy, highlighting the value of following NCCN guideline recommendations and the need for timely access to biomarker testing and individualized treatment.

ADVANCES IN THERAPY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Medicine, General & Internal

Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement

Alex H. Krist et al.

Summary: Lung cancer is the second most common cancer and leading cause of cancer death in the US, with smoking and increasing age being the primary risk factors. Annual screening with low-dose computed tomography is recommended for adults aged 50 to 80 years with a 20 pack-year smoking history.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Biochemistry & Molecular Biology

Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma

E. A. Rozeman et al.

Summary: The combination of neoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma. High tumor mutational burden (TMB) and high interferon-gamma-related gene expression signature score (IFN-gamma score) were associated with pathologic response and a low risk of relapse. These findings support the potential predictive value of TMB and IFN-gamma score in the treatment of melanoma patients.

NATURE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Tina Cascone et al.

Summary: The NEOSTAR trial showed that neoadjuvant treatment with nivolumab + ipilimumab combination therapy can improve pathologic response rates in operable NSCLC patients and has better clinical efficacy compared to nivolumab alone.

NATURE MEDICINE (2021)

Article Oncology

Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial

Nasser K. Altorki et al.

Summary: The combination of neoadjuvant durvalumab and stereotactic body radiotherapy in early-stage NSCLC patients shows a high major pathological response rate and is well tolerated, suggesting its potential in treatment, although it comes with certain adverse events.

LANCET ONCOLOGY (2021)

Review Oncology

Preoperative Cardiopulmonary Exercise Test Associated with Postoperative Outcomes in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analyses

Daniel Steffens et al.

Summary: The study found a significant association between superior preoperative CPET values, especially peak VO2, and better postoperative outcomes. Other CPET variables also showed positive trends, with no negative trends reported in any of the included studies.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Immunology

Integration of immunotherapy into adjuvant therapy for resected non-small-cell lung cancer: ALCHEMIST chemo-IO (ACCIO)

Jacob M. Sands et al.

Summary: Non-small-cell lung cancer (NSCLC) causes significant mortality each year. Adjuvant platinum-based chemotherapy improves median overall survival, but many patients still experience disease recurrence. Including pembrolizumab in treatment regimens may improve outcomes for patients.

IMMUNOTHERAPY (2021)

Article Medicine, General & Internal

Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial

Enriqueta Felip et al.

Summary: IMpower010 study demonstrated a disease-free survival benefit with adjuvant atezolizumab versus best supportive care in patients who underwent complete resection followed by adjuvant chemotherapy, especially in the subgroup whose tumors expressed PD-L1 on 1% or more of tumor cells.

LANCET (2021)

Article Respiratory System

Diastolic Dysfunction Contributes to Impaired Cardiorespiratory Fitness in Patients with Lung Cancer and Reduced Lung Function Following Chest Radiation

Georgia K. Thomas et al.

Summary: Cardiorespiratory fitness is a strong predictor of cardiovascular health and overall mortality. Patients with lung cancer receiving radiotherapy may experience reduced CRF, with diastolic dysfunction and NTproBNP levels inversely correlated with peak VO2. NTproBNP is the strongest independent variable associated with peak VO2 in this population, indicating its significance in predicting CRF.
Article Pharmacology & Pharmacy

Longitudinal Tumor Size and Neutrophil-to-Lymphocyte Ratio Are Prognostic Biomarkers for Overall Survival in Patients With Advanced Non-Small Cell Lung Cancer Treated With Durvalumab

Sergey Gavrilov et al.

Summary: Therapy optimization in advanced non-small cell lung cancer (NSCLC) is a significant challenge. A study used tumor size and neutrophil-to-lymphocyte ratio as longitudinal biomarkers for survival prediction, finding that incorporating longitudinal measurements can improve patient subgrouping and increase the precision of survival estimates. The highest performance was achieved using a multivariate model, enabling predictions of NSCLC clinical outcomes.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2021)

Article Oncology

Neoadjuvant PD-1 inhibitor (Sintilimab) in NSCLC

Shugeng Gao et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

Article Medicine, General & Internal

Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer

Yi-Long Wu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer

Joshua E. Reuss et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Initial results of pulmonary resection after neoadjuvant nivolumab in patients with resectable non-small cell lung cancer

Matthew J. Bott et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2019)

Review Oncology

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Medicine, General & Internal

Biomarkers for Immune Checkpoint Inhibitor-Mediated Tumor Response and Adverse Events

Yoshiyuki Nakamura

FRONTIERS IN MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer

Chi-Fu Jeffrey Yang et al.

ANNALS OF THORACIC SURGERY (2018)

Article Medicine, General & Internal

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

P. M. Forde et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Letter Medicine, General & Internal

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

Xin Yang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Respiratory System

Management of stage I and II nonsmall cell lung cancer

Fiona McDonald et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Article Oncology

Non-Small Cell Lung Cancer, Version 5.2017 Clinical Practice Guidelines in Oncology

David S. Ettinger et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2017)

Article Cardiac & Cardiovascular Systems

Long-term pulmonary function after surgery for lung cancer

Naohiro Kobayashi et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2017)

Article Cardiac & Cardiovascular Systems

Validating the Thoracic Revised Cardiac Risk Index Following Lung Resection

Daniel C. Thomas et al.

ANNALS OF THORACIC SURGERY (2017)

Article Cardiac & Cardiovascular Systems

Endoscopic Mediastinal Staging in Lung Cancer Is Superior to Gold Standard Surgical Staging

Ilyes Berania et al.

ANNALS OF THORACIC SURGERY (2016)

Review Oncology

The Utility of Exercise Testing in Patients with Lung Cancer

Duc Ha et al.

JOURNAL OF THORACIC ONCOLOGY (2016)

Article Surgery

Risk Stratification in Lung Resection

Michele Salati et al.

CURRENT SURGERY REPORTS (2016)

Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Evaluation of 2 Real-Time PCR Assays for In Vitro Diagnostic Use in the Rapid and Multiplex Detection of EGFR Gene Mutations in NSCLC

Anthony T. C. Wong et al.

DIAGNOSTIC MOLECULAR PATHOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Diffusing capacity predicts long-term survival after lung resection for cancer

Mark K. Ferguson et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2012)

Review Surgery

Surgical Trauma and Postoperative Immune Dysfunction

P. Menges et al.

EUROPEAN SURGICAL RESEARCH (2012)

Review Surgery

Surgery induced immunosuppression

Brian V. Hogan et al.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND (2011)

Article Cardiac & Cardiovascular Systems

Recalibration of the Revised Cardiac Risk Index in Lung Resection Candidates

Alessandro Brunelli et al.

ANNALS OF THORACIC SURGERY (2010)

Review Oncology

Integrins in cancer: biological implications and therapeutic opportunities

Jay S. Desgrosellier et al.

NATURE REVIEWS CANCER (2010)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Article Medicine, General & Internal

Preoperative Staging of Lung Cancer with Combined PET-CT.

Barbara Fischer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Oncology

Adjuvant chemotherapy for non-small cell lung cancer

Emilio Bria et al.

JOURNAL OF THORACIC ONCOLOGY (2007)

Review Medicine, General & Internal

Understanding the basics of cardiopulmonary exercise testing

Richard V. Milani et al.

MAYO CLINIC PROCEEDINGS (2006)

Article Surgery

Increased surgical stress promotes tumor metastasis

Y Tsuchiya et al.

SURGERY (2003)

Article Oncology

New guidelines to evaluate the response to treatment in solid tumors

F Duffaud et al.

BULLETIN DU CANCER (2000)

Article Oncology

New guidelines to evaluate the response to treatment in solid Tumors

P Therasse et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)