☆ 4.7 Review

Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

BIOMARKER RESEARCH (2023)

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Review Biochemistry & Molecular Biology

Regulation of intrinsic and extrinsic metabolic pathways in tumour-associated macrophages

Goutham Venkata Naga Davuluri et al.

Summary: TAMs can be converted between different functional states through the regulation of cytokines and metabolites in the microenvironment. Dysregulated metabolism plays a crucial role in TAM differentiation and function. Extracellular metabolites within the tumor microenvironment can regulate TAMs through competition for metabolite availability and direct signaling reactions.

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Article Engineering, Biomedical

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Zhilin Li et al.

Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.

BIOACTIVE MATERIALS (2023)

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Review Immunology

Metabolic manipulation of the tumour immune microenvironment

Mengtian Wan et al.

Summary: This paper discusses metabolic reprogramming in tumor cells and the influence of metabolite by-products on the immune microenvironment, providing novel insights into tumor immunotherapy.

IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

TBC1D14 inhibits autophagy to suppress lymph node metastasis in head and neck squamous cell carcinoma by downregulating macrophage erythroblast attacher

Tao Lu et al.

Summary: This study identified TBC1D14 as a novel LNM inhibitor in head and neck squamous cell carcinoma (HNSCC) and a favorable prognostic marker. TBC1D14 suppresses autophagy to inhibit LNM in HNSCC by downregulating MAEA expression.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Dentistry, Oral Surgery & Medicine

GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer

S. Wang et al.

Summary: Gasdermin E (GSDME) is highly expressed in oral squamous cell carcinoma (OSCC) and is associated with better prognosis. Chemotherapy drugs can induce GSDME-mediated pyroptosis, and the loss of GSDME function attenuates the anti-tumor effect of cisplatin.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Oncology

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

Elisa Rioja-Blanco et al.

Summary: Novel therapeutic strategies are urgently needed for HNSCC patients with therapy resistance. T22-PE24-H6 and T22-DITOX-H6 nanotoxins show promising potential for the treatment of HNSCC by specifically targeting CXCR4-overexpressing cells and triggering caspase-3/GSDME-dependent pyroptosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Cell Biology

Molecular mechanisms and consequences of mitochondrial permeability transition

Massimo Bonora et al.

Summary: Mitochondrial permeability transition, mediated by the opening of the mitochondrial permeability transition pore, causes flux of low molecular weight solutes across the inner mitochondrial membrane, triggering various cellular responses. Recent studies have shed light on the molecular nature and mechanisms of the mitochondrial permeability transition pore, paving the way for understanding mitochondrial biology and its pathophysiological consequences.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Targeting HIF-1 alpha/NOTCH1 pathway eliminates CD44(+) cancer stem-like cell phenotypes, malignancy, and resistance to therapy in head and neck squamous cell carcinoma

Joo-Yun Byun et al.

Summary: Poor prognosis of head and neck squamous cell carcinomas (HNSCCs) is mainly due to resistance to chemotherapy and radiotherapy. Activation of HIF-1 alpha in CD44(+) HNSCC patients was associated with worse prognosis. HIF-1 alpha promoted stemness, resistance, and epithelial-mesenchymal transition in HNSCC CD44(+) cells.

ONCOGENE (2022)

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Article Multidisciplinary Sciences

Bacterial gasdermins reveal an ancient mechanism of cell death

Alex G. Johnson et al.

Summary: Gasdermin proteins play important roles in immune regulation and induction of cell death in human cells by forming membrane pores. Similar proteins encoded by bacteria have been found to defend against phages and execute cell death.

SCIENCE (2022)

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Article Gastroenterology & Hepatology

Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis

Ping Sun et al.

Summary: This study found that hepatocytes can activate pyroptosis pathways and cleave gasdermin-D (GSDMD), but unlike macrophages, pyroptotic hepatocytes do not exhibit significant cell rupture and morphological changes. These findings have important implications for understanding and recognizing the role of these pathways in hepatocytes, and may lead to the development of novel therapeutics for liver diseases.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Autophagy in cancer cell remodeling and quality control

Grace A. Hernandez et al.

Summary: Autophagy plays a critical role in tumor progression and is a target for anti-cancer interventions. Dysregulation of autophagy leads to metabolic reprogramming and enhanced adaptability in tumor cells. Proteomics-based approaches provide insights into the composition and functions of autophagy.

MOLECULAR CELL (2022)

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Review Biotechnology & Applied Microbiology

Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment

Giulia Petroni et al.

Summary: Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple tumours, but only a few patients respond to ICIs. This article discusses the potential of targeting oncogene and non-oncogene addiction to enhance ICI sensitivity and convert immunologically 'cold' tumours into 'hot' lesions.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Cell Biology

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas

Ling Gao et al.

Summary: This study reveals that circ-PKD2 plays a role in cisplatin-induced autophagy in oral squamous cell carcinoma cells, and miR-646 plays a critical role in regulating the effects of circ-PKD2 in chemotherapy.

CELL DEATH & DISEASE (2022)

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Article Oncology

Identification of pyroptosis-related gene prognostic signature in head and neck squamous cell carcinoma

Zhanzhan Li et al.

Summary: We constructed and validated a risk model for HNSCC prognosis using seven pyroptosis-related signature genes, which could predict the overall survival of HNSCC patients and facilitate treatment.

CANCER MEDICINE (2022)

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Article Oncology

Prognosis and Characterization of Immune Microenvironment in Head and Neck Squamous Cell Carcinoma through a Pyroptosis-Related Signature

Lin Lu et al.

Summary: Pyroptosis, an identified programmed cell death, is closely related to tumor immunity and has potential roles in cancer treatment. A study constructed a six pyroptosis-related gene signature that is closely associated with tumor immune microenvironment in head and neck squamous cell carcinoma. The signature showed good performance in predicting survival and has immune-related functions. Furthermore, the study explored the immune landscape and immunotherapy sensitivity prediction capabilities of the signature. A nomogram based on the risk score and clinicopathological parameters was also constructed and demonstrated better sensitivity and specificity than other scores.

JOURNAL OF ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Weijun Xu et al.

Summary: Cuproptosis is a newly recognized regulated cell death mechanism that shows promise in cancer treatment. A novel copper/iron hybrid hollow metal organic framework (HaMOF) is developed for synergistic anticancer therapy by amplifying oxidative stress and disrupting copper/iron metabolism. The bimetallic hollow nanoplatform induces potent ferroptosis and cuproptosis, and efficiently suppresses tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Medicine, General & Internal

A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

Tong Tong et al.

Summary: The study identified the role of the CREB5/TOP1MT axis in conferring cisplatin resistance in HNSCC, and provided a new basis for overcoming this resistance.

BMC MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Madelaine Magali Audero et al.

Summary: This review presents the impact of hypoxia and acidosis in the tumor microenvironment (TME) on cancer progression, and focuses on the role of Ca2+ channels in this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Nanoscience & Nanotechnology

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Zhiyan Li et al.

Summary: This article introduces the application of nanomaterial-assisted starvation treatment in cancer therapy. By elaborating on the interactions between different treatment mechanisms, this method can address the limitations of traditional treatments. The obstacles and potential for advancing these anticancer therapies are also highlighted in this review.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

Hes1 Controls Proliferation and Apoptosis in Chronic Lymphoblastic Leukemia Cells by Modulating PTEN Expression

Qikai Zhang et al.

Summary: This study reveals that the high expression of HES1 and Notch1, as well as the low expression of PTEN, is associated with poor prognosis in CLL patients. Activation of the HES1-mediated Notch1 signaling pathway promotes CLL cell proliferation and inhibits apoptosis.

MOLECULAR BIOTECHNOLOGY (2022)

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Article Oncology

Necroptosis pathways in tumorigenesis

Tao Zhang et al.

Summary: This review summarizes the recent findings on the link between necroptosis and cancer, and discusses targeting necroptosis as a new strategy to overcome apoptosis resistance in tumor therapy.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Cell Biology

Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma

Syed S. Islam et al.

Summary: The study found that Keap1 mutations lead to activation of Nrf2, promoting cancer cell growth and resistance to oxidative stress, while also affecting the efficacy of chemotherapy. Limiting Nrf2 activity can increase sensitivity to chemotherapy and suppress cancer stem cell self-renewal.

CELL DEATH & DISEASE (2022)

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Article Oncology

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer

Mirunalini Ravichandran et al.

Summary: The mechanisms of metabolic adaptation of pancreatic ductal adenocarcinoma cells to pharmacologic inhibition of RAS-MAPK signaling are not well understood. This study reveals that the MEK inhibitor trametinib leads to downregulation of c-MYC and increased MiT/TFE-dependent lysosome biogenesis in PDA cells. Furthermore, it is found that increased ferritinophagy promotes mitochondrial iron-sulfur cluster protein synthesis and enhanced mitochondrial respiration. Inhibition of iron utilization sensitizes PDA cells to MEKi.

CANCER DISCOVERY (2022)

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Article Immunology

Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer

Qiang Song et al.

Summary: In this study, we investigated the characteristic patterns of cuproptosis and its relationship with clinical outcomes and the tumor microenvironment in bladder cancer. By establishing a cuproptosis score, we were able to predict prognosis and treatment response in bladder cancer patients. Our findings suggest that cuproptosis may play a role in the development and progression of bladder cancer through its interaction with the tumor microenvironment.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Cuproptosis and cuproptosis-related genes in rheumatoid arthritis: Implication, prospects, and perspectives

Jianan Zhao et al.

Summary: This study explores the link between cuproptosis and the pathological mechanisms of rheumatoid arthritis (RA), as well as its effects on various immune cells. The findings provide a theoretical basis for translating preclinical and experimental results into clinical protocols for RA treatment.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer

Shengnan Sha et al.

Summary: This study investigates the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The results show that CRGs are closely associated with tumor immunity in TNBC and can be used to evaluate tumor immune cell infiltration, clinical features, and prognosis. This research provides new directions for the development of novel drugs in the future.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Cell Biology

Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications

Anabela Ferreira et al.

Summary: KRAS mutations play a crucial role in promoting cancer cell proliferation, inducing autophagy, and suppressing apoptosis, leading to drug resistance and poor prognosis.

CELLS (2022)

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Article Oncology

Arecoline Is Associated With Inhibition of Cuproptosis and Proliferation of Cancer-Associated Fibroblasts in Oral Squamous Cell Carcinoma: A Potential Mechanism for Tumor Metastasis

Jinfei Li et al.

Summary: This study found a close association between arecoline, cuproptosis, and CAFs, which might play an important role in the metastasis of OSCC.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Gabriel Ichim et al.

Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma

Fei Liu et al.

Summary: This study identified a close correlation between ferroptosis and the prognosis and development of HNSCC, suggesting that the ferroptosis pathway could be a potential therapeutic target for HNSCC.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Biology

Identification of cuproptosis-related subtypes, establishment of a prognostic model and tumor immune landscape in endometrial carcinoma

Jingsong Shan et al.

Summary: Cuproptosis, a mechanism of copper-dependent cell death, has the potential to be a new treatment for tumors resistant to conventional therapies. By analyzing changes in cuproptosis-related genes in endometrial cancer cohorts, three distinct gene clusters were identified, with patients in one cluster having higher survival probability and tumor microenvironment cell infiltration levels. A risk scoring system based on these genes can stratify patients into high-risk and low-risk groups, where low-risk patients have better prognosis and immunotherapy efficacy. Furthermore, the gene scores are correlated with other indicators such as copy number variation and tumor mutation load.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

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Review Biochemistry & Molecular Biology

KRAS-Mutant Non-Small-Cell Lung Cancer: From Past Efforts to Future Challenges

Serena Ceddia et al.

Summary: This review analyzes the latest research progress on KRAS mutations in non-small-cell lung cancer, describes the biological structure of KRAS, and explores its clinical relevance as a prognostic and predictive biomarker. In addition, this article reviews different treatment approaches for KRAS-mutant lung cancers, with a focus on novel therapeutic strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Exploring the potential targets of Sanshimao formula for hepatocellular carcinoma treatment by a method of network pharmacology combined with molecular biology

Qin Yu et al.

Summary: This research preliminarily indicates that Sanshimao (SSM) formula treats hepatocellular carcinoma (HCC) via multiple components and pathways. EGFR/FAK/AKT are promising therapeutic targets of SSM for HCC treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Oncology

The current state of the art and future trends in RAS-targeted cancer therapies

Salman R. Punekar et al.

Summary: Despite being historically considered 'undruggable', improvements in drug design have led to the development of inhibitors that target KRAS mutations in solid tumors. Some of these inhibitors have shown efficacy in patients with KRAS (G12C)-mutant cancers, but drug resistance limits their effectiveness. However, there is potential for novel combination therapies, which are currently being explored in clinical trials, to overcome resistance mechanisms. This article provides an overview of the RAS pathway and reviews the current strategies for targeting oncogenic RAS, as well as the challenges presented by drug resistance mechanisms.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Nucleolar protein NOC4L inhibits tumorigenesis and progression by attenuating SIRT1-mediated p53 deacetylation

Xiaomeng Jia et al.

Summary: This study identified a novel SIRT1 regulatory protein, NOC4L, that binds to and inhibits the deacetylation of p53 mediated by SIRT1. Overexpression of NOC4L increases p53 acetylation and promotes cell apoptosis, while inhibiting tumor cell proliferation and tumor growth in a p53-dependent manner.

ONCOGENE (2022)

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Article Oncology

Identification of a Novel Cuproptosis-Related Gene Signature for Prognostic Implication in Head and Neck Squamous Carcinomas

Shouyi Tang et al.

Summary: This study identified a 24-gene signature for predicting the overall survival of head and neck squamous carcinoma (HNSC) patients. The study also found that patients in the high-risk group had worse prognosis compared to the low-risk group. Furthermore, significant differences were observed between the two groups in metabolic pathways and immune microenvironment.

CANCERS (2022)

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Review Oncology

The interactive role of inflammatory mediators and metabolic reprogramming in pancreatic cancer

Yuuki Ohara et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type, with development intricately linked to inflammatory signaling and metabolic reprogramming. Understanding the interaction of these factors may provide new insights for the treatment of PDAC.

TRENDS IN CANCER (2022)

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Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

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Article Gastroenterology & Hepatology

Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target

Vaibhav Singh et al.

Summary: This study investigates the impact of chronic ethanol feeding on the hepatic phosphoproteome, focusing on the death receptor signaling pathways. It is found that chronic ethanol dysregulates these pathways and decreases the inhibitory phosphorylation of ASK1, a critical protein involved in programmed cell death. Furthermore, the study suggests the involvement of noncanonical functions of RIP3 in alcohol-associated liver disease.

HEPATOLOGY COMMUNICATIONS (2022)

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Review Oncology

Necroptosis and tumor progression

Jiong Yan et al.

Summary: Necroptosis, a form of programmed necrotic cell death, plays a crucial role in host defense and inflammatory diseases, and has emerged as an important factor in tumorigenesis and metastasis, suggesting its potential as a novel cancer therapy target.

TRENDS IN CANCER (2022)

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Article Plant Sciences

Exploring the potential targets of Sanshimao formula for hepatocellular carcinoma treatment by a method of network pharmacology combined with molecular biology

Qin Yu et al.

Summary: The study identified potential targets and mechanisms of the Sanshimao formula in treating hepatocellular carcinoma through network pharmacology analysis, and validated the data using molecular biological methods.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation

Qingyu Zhang et al.

Summary: Metabolic alterations, particularly in the fatty-acid metabolism, play a key role in promoting cancer cell metastasis, with the protein ACSL1 identified as a crucial regulator in enhancing metastasis through regulating FA metabolism and myristoylation. The study highlights the importance of understanding metabolic reprogramming in cancer progression and the potential for targeting ACSL1 as a therapeutic strategy for inhibiting metastasis.

ONCOGENE (2021)

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Article Oncology

Delta-Like Ligand-Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Maryam Khelil et al.

Summary: This study investigates origins of cervical cancer cells and describes a DLL-Notch1 phenotype associated with disease prognosis, potentially aiding in the identification of cells susceptible to HPV-induced carcinogenesis.

CANCER RESEARCH (2021)

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Review Oncology

GSDME and its role in cancer: From behind the scenes to the front of the stage

Elke De Schutter et al.

Summary: GSDME, originally involved in hereditary hearing loss, has been associated with various cancers and may act as a tumor suppressor; differential methylation and gene expression patterns of GSDME are closely related to tumorigenesis and hold potential as detection and prognostic biomarkers in cancer; while GSDME protein expression is considered unsuitable as a biomarker, it still plays a role in tumor immunogenicity.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

Bo Yan et al.

Summary: Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of polyunsaturated phospholipids on cell membranes, which is carried out by oxidoreductases transferring electrons to oxygen to generate hydrogen peroxide for lipid peroxidation. This process needs to be counteracted by antioxidant systems to prevent cell death.

MOLECULAR CELL (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Ke Xu et al.

Summary: The passage discusses the impact of infection on T cell immune response, highlighting the crucial role of glycolytic enzyme LDHA in regulating the PI3K-Akt-Foxo1 signaling pathway, a mechanism that serves as a key factor in controlling T cell immunity.

SCIENCE (2021)

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Review Oncology

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

Sheera R. Rosenbaum et al.

Summary: Using immune checkpoint inhibitors (ICI) has significantly improved overall survival for certain cancer patients, but many tumors do not respond due to a lack of tumor-infiltrating lymphocytes (TIL). Converting immune cold tumors to hot tumors is a key obstacle in cancer treatment. Promoting tumor-localized necroptosis and pyroptosis may enhance responses to ICI.

CANCER DISCOVERY (2021)

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Review Oncology

Targeting mutant p53 for cancer therapy: direct and indirect strategies

Jiahao Hu et al.

Summary: TP53 is a critical tumor-suppressor gene commonly mutated in human cancers, with potential oncogenic properties when mutated. Treatments for cancers with mutant p53 involve targeting mutant p53 directly, restoring wild-type functions, and exploring synthetic lethal interactions with mutant p53 for therapeutic benefits. Additionally, disrupting noncoding RNA networks may have potential synthetic lethal effects in cancers with p53 mutations.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

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Review Otorhinolaryngology

Association Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review

Uzdan Uz et al.

Summary: This systematic review evaluates the activity of IL-6 in patients with head and neck squamous cell carcinoma (HNSCC). The findings suggest that elevated IL-6 concentrations in patients with HNSCC are associated with poor survival and oncological outcomes. Current IL-6 targeted therapies are mainly conducted in vitro and experimental studies, highlighting the need for prospective, randomized clinical trials to assess their effectiveness in treating HNSCC.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY (2021)

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Review Biochemistry & Molecular Biology

Epigenetic modulation of antitumor immunity for improved cancer immunotherapy

Enyong Dai et al.

Summary: Epigenetic mechanisms play important roles in cancer initiation and immune cell function, with the potential to impact tumor microenvironment and therapeutic efficacy by modulating immune cell populations and promoting transcriptional and metabolic reprogramming. By regulating immune-associated genes and immune checkpoint molecules, epigenetic modulating agents can enhance tumor immunogenicity and facilitate anti-tumor immune responses.

MOLECULAR CANCER (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Channelling inflammation: gasdermins in physiology and disease

Xing Liu et al.

Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Multidisciplinary Sciences

Dying cells fan the flames of inflammation

Kim Newton et al.

Summary: Inflammatory processes are crucial for tissue repair and pathogen elimination, but excessive or chronic inflammation can lead to diseases such as arthritis and COVID-19. Different cell death mechanisms like apoptosis, necroptosis, and pyroptosis may contribute to inflammatory diseases. Inhibiting cell death and targeting specific mediators of lytic cell death could be potential therapeutic strategies.

SCIENCE (2021)

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Review Oncology

Hypoxia-induced therapy resistance: Available hypoxia-targeting strategies and current advances in head and neck cancer

Victoria L. Codony et al.

Summary: Solid tumors like head and neck cancers exhibit hypoxic microenvironment due to angiogenic dysregulation and vascular disruption, leading to genomic changes in tumor cells and increased resistance to therapy. Clinical studies have focused on HIF-inhibitors, hypoxia-activated prodrugs, and anti-angiogenic agents, but many drugs fail clinical trials due to inadequate drug delivery.

TRANSLATIONAL ONCOLOGY (2021)

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Review Cell Biology

Cell death in head and neck cancer pathogenesis and treatment

Martina Raudenska et al.

Summary: Many cancer therapies target apoptosis in cancer cells, but the presence of oncogenic alterations and tumor microenvironment composition limit their efficacy. There are about 10 different cell death subroutines that cancer cells cannot avoid, highlighting the need for individualized therapy. Understanding the molecular heterogeneity of tumors and their cell death pathways is crucial for improving treatment response.

CELL DEATH & DISEASE (2021)

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Review Oncology

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Lei Wang et al.

Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mechanisms of Ferroptosis and Application to Head and Neck Squamous Cell Carcinoma Treatments

Shuang Li et al.

Summary: Ferroptosis, a novel type of iron-dependent cell death, plays a significant role in inducing cancer cell death through the accumulation of reactive oxygen species and lipid peroxidation. However, there is considerable uncertainty regarding the role of ferroptosis in head and neck cancer, and no review of current studies on this topic has been published so far.

DNA AND CELL BIOLOGY (2021)

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Article Immunology

An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma

Xinwen Wang et al.

Summary: By identifying ICD-associated subtypes, a new classification system based on ICD signatures can be established in HNSCC patients, which helps in assessing prognosis and effectiveness of immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Ferroptosis and its emerging roles in cardiovascular diseases

Ning Li et al.

Summary: Ferroptosis, a novel form of regulated cell death driven by iron-dependent lipid peroxidation, has been found to play a role in various cardiovascular diseases, but the specific mechanisms by which it contributes to the progression of cardiovascular diseases remain unclear.

PHARMACOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Qiaozhi Wei et al.

Summary: The study reveals the essential role of Macrophage-Erythroblast Attacher (MAEA) in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy. MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.

NATURE COMMUNICATIONS (2021)

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Article Oncology

Molecular Characteristics, Prognostic Value, and Immune Characteristics of m6A Regulators Identified in Head and Neck Squamous Cell Carcinoma

Xiuchao Geng et al.

Summary: This study systematically analyzed the molecular characteristics of m(6)A modification in a pan-cancer genomic analysis, revealing that IGF2BP2 may serve as an independent prognostic factor in head and neck squamous cell carcinoma (HNSCC) and is associated with immune cell infiltration.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers

Yuzuka Kanno et al.

Summary: This review discusses the molecular mechanisms of chemotherapy resistance in head and neck cancer and potential strategies for improving treatment outcomes, suggesting combination therapies with immunotherapy may be beneficial for prolonging survival.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring

Sanjib Chaudhary et al.

Summary: This study demonstrates that the combination therapy of CDK4/6 and panEGFR inhibitors can significantly reduce tumor growth, induce cellular senescence, and regulate metabolic pathways in HNSCC, suggesting that dual targeting may be a critical therapeutic strategy in blocking tumor progression.

CANCER LETTERS (2021)

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Article Oncology

Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Wei Gao et al.

Summary: Elesclomol inhibits colorectal cancer by inducing copper overload, promoting oxidative stress, and regulating ferroptosis through targeting ATP7A.

MOLECULAR ONCOLOGY (2021)

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Review Cell Biology

Machinery, regulation and pathophysiological implications of autophagosome maturation

Yan G. Zhao et al.

Summary: Autophagosome maturation is a crucial process for maintaining cellular homeostasis and autophagic degradation, involving a variety of regulatory factors working together. Its dysregulation is associated with neurodegenerative disorders, muscle diseases, cancer, and the survival of invading pathogens.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Medicine, General & Internal

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

Jack J. Collier et al.

Summary: This study identified several patients with neurodevelopmental disorders who survived with severe loss or complete absence of ATG7, an essential effector enzyme for autophagy without a known functional paralogue.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

The Importance of Being Autophagic

Ian Ganley

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Hanyue Chang et al.

Summary: The study demonstrates that upregulation of pyruvate kinase M2 leads to lactate production which promotes tumor progression and immunosuppression in head and neck squamous cell carcinoma (HNSCC) via inhibition of NF-kappa B signaling. Lactate affects the formation of the suppressive transcriptional complex of NF-kappa B and histone deacetylase 3 (HDAC3), resulting in the transcription of Galectin-9.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Xianfang Liu et al.

Summary: Afatinib induces autophagy in HNSCC cells through mTORC1 suppression, REDD1-TSC1 signaling activation, and ROS generation. Inhibition of autophagy enhances afatinib-induced apoptosis, indicating the potential of targeting pro-survival autophagy in HNSCC cells. Combination treatment with afatinib and autophagy inhibitors may eradicate HNSCC cells, especially cancer stem cells, in clinical therapy.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

Zhang-Wei Hu et al.

Summary: The study identified the ferroptosis driver SOCS1 and suppressor FTH1 as independent prognostic factors in head and neck squamous cell carcinoma, correlating with M1 and M2 macrophage infiltration. Targeting ferroptosis-immunomodulation may enhance immunotherapy efficacy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Oncology

The role of non-coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Xiang Meng et al.

Summary: Oral squamous cell carcinoma (OSCC) is influenced by multiple factors including tobacco and alcohol consumption. Nano-delivery and self-cellular drug delivery platforms are effective strategies to overcome drug resistance, while the application of new technologies opens up new opportunities for the treatment of drug resistance.

CANCER COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

Modulation of Intracellular Copper Levels as the Mechanism of Action of Anticancer Copper Complexes: Clinical Relevance

Maria Babak et al.

Summary: Copper plays a crucial role in cellular growth and development and its imbalance can lead to toxicity. This review explores the mechanisms of intracellular copper balance interference in tumor development and progression, and discusses the potential of using copper-depleting and copper-overloading conditions for improved patient outcomes. Additionally, the advantages of pre-formed copper complexes in comparison to in situ formed complexes are highlighted.

BIOMEDICINES (2021)

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Review Oncology

Targeting the DNA damage response in immuno-oncology: developments and opportunities

Roman M. Chabanon et al.

Summary: Immunotherapy has greatly improved cancer treatment outcomes, but many patients still do not benefit from it, partly due to DDR deficiency. DDR-targeted therapies can enhance antitumor immune response by promoting antigenicity, enhancing adjuvanticity, and favoring reactogenicity.

NATURE REVIEWS CANCER (2021)

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Review Immunology

Metabolic barriers to cancer immunotherapy

Kristin DePeaux et al.

Summary: The tumour microenvironment creates barriers that suppress immune responses, including physical barriers, recruitment of suppressive immune cells, and upregulation of inhibitory ligands on tumour cells. Therapies targeting metabolic restrictions in the tumour microenvironment show promise for combination therapies against various types of cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Dentistry, Oral Surgery & Medicine

The role of autophagy in the pathogenesis of periodontal disease

Ming Jiang et al.

ORAL DISEASES (2020)

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Review Cell Biology

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease

Giovanni Blandino et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Autophagosome-Lysosome Fusion

Peter Lorincz et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Cell Biology

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

Huaize Liu et al.

AUTOPHAGY (2020)

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Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

The function of SNHG7/miR-449a/ACSL1 axis in thyroid cancer

Linchi Guo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Medicine, Research & Experimental

Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma

Thomas J. Ow et al.

LARYNGOSCOPE (2020)

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Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

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Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Targeting necroptosis in anticancer therapy: mechanisms and modulators

Ying Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Oncology

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

Yiqiu Li et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa

Giovanna Carra et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Article Cell Biology

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent manner

Chunyan Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

Sampath K. Loganathan et al.

SCIENCE (2020)

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Article Cell Biology

Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model

Jingyuan Li et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang et al.

NATURE (2020)

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Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Editorial Material Biotechnology & Applied Microbiology

Pyroptosis heats tumour immunity

Kirsty Minton

NATURE REVIEWS DRUG DISCOVERY (2020)

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News Item Biotechnology & Applied Microbiology

PIP5K1A: a potential target for cancers with KRAS or TP53 mutations

Michael P. East et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Review Cell Biology

Mechanisms governing autophagosome biogenesis

Hitoshi Nakatogawa

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Copper homeostasis: Emerging target for cancer treatment

Yueqin Li

IUBMB LIFE (2020)

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Article Oncology

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

Florida Voli et al.

CANCER RESEARCH (2020)

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Review Cell Biology

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Oncology

Regulation of NFκB Signalling by Ubiquitination: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma?

Ethan L. Morgan et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Anna Negroni et al.

BIOMOLECULES (2020)

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Review Immunology

Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease

Lindsey E. Fox et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Oncology

Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer

Sreevidya Santha et al.

CANCERS (2020)

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Article Medicine, Research & Experimental

Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis

Burak Uzunparmak et al.

JCI INSIGHT (2020)

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Article Immunology

Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis

Xudong Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Cell Biology

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Mingxia Jiang et al.

CELL DEATH DISCOVERY (2020)

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Letter Biochemistry & Molecular Biology

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Changzhi Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Oncology

Turning Cold into Hot: Firing up the Tumor Microenvironment

Qianqian Duan et al.

TRENDS IN CANCER (2020)

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Review Medicine, General & Internal

Head and Neck Cancer

Laura Q. M. Chow

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Biochemistry & Molecular Biology

The tumor suppressor protein p53 and the ferroptosis network

Rui Kang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

The release and activity of HMGB1 in ferroptosis

Qirong Wen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Medicine, General & Internal

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

Mengjiao Wu et al.

EBIOMEDICINE (2019)

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Review Biochemistry & Molecular Biology

The role of necroptosis in cancer: A double-edged sword?

Xia Qin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Article Oncology

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

Mercedes Segovia et al.

CANCER CELL (2019)

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Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

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Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

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Article Oncology

Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma

Wenyi Yang et al.

CANCER LETTERS (2019)

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Article Oncology

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

Roy Xiao et al.

CLINICAL CANCER RESEARCH (2019)

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Article Oncology

Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC

Sarah-Louise Ryan et al.

LUNG CANCER (2019)

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Article Multidisciplinary Sciences

Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling

Jiao Wu et al.

NATURE (2019)

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Article Multidisciplinary Sciences

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Yilong Zou et al.

NATURE COMMUNICATIONS (2019)

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Article Neurosciences

Long noncoding RNA H19 prevents neurogenesis in ischemic stroke through p53/Notch1 pathway

Jue Wang et al.

BRAIN RESEARCH BULLETIN (2019)

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Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

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Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

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Article Biochemistry & Molecular Biology

E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model

Alfredo Cruz-Gregorio et al.

BIOMOLECULES (2019)

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Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

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Article Cell Biology

CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas

Ling Gao et al.

Cell Death & Disease (2019)

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Article Oncology

Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma

Hailong Ma et al.

BRITISH JOURNAL OF CANCER (2019)

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Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Oncology

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann Angeli et al.

NATURE REVIEWS CANCER (2019)

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Article Medicine, Research & Experimental

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter

Feng Shi et al.

THERANOSTICS (2019)

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Article Oncology

NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma

Han Wang et al.

BMC CANCER (2018)

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Article Environmental Sciences

Cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp Litopenaeus vannamei

Dahlia M. Nunez-Hernandez et al.

CHEMOSPHERE (2018)

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Article Biochemistry & Molecular Biology

High NOTCH1 mRNA Expression Is Associated with Better Survival in HNSCC

Markus Wirth et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Cell Biology

Regulation of Tumor Progression by Programmed Necrosis

Su Yeon Lee et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Multidisciplinary Sciences

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur et al.

SCIENCE (2018)

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Article Cell Biology

Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis

Suling Ding et al.

CELL DEATH & DISEASE (2018)

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Article Cell Biology

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Amy Tarangelo et al.

CELL REPORTS (2018)

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Editorial Material Cell Biology

Metabolic control of ferroptosis in cancer

Michael P. Murphy

NATURE CELL BIOLOGY (2018)

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Review Gastroenterology & Hepatology

Apoptosis and necroptosis in the liver: a matter of life and death

Robert F. Schwabe et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Multidisciplinary Sciences

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli et al.

NATURE COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer

Ali Masjedi et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Biochemistry & Molecular Biology

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Michele Carbone et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Oncology

Targeted p53 on Small-Molecules-Induced Ferroptosis in Cancers

Weifen Zhang et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Oncology

The molecular landscape of head and neck cancer

C. Rene Leemans et al.

NATURE REVIEWS CANCER (2018)

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Review Oncology

Targeting mutant p53 for efficient cancer therapy

Vladimir J. N. Bykov et al.

NATURE REVIEWS CANCER (2018)

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Article Biochemistry & Molecular Biology

MOMP, cell suicide as a BCL-2 family business

Halime Kalkavan et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Biochemistry & Molecular Biology

Why are there hotspot mutations in the TP53 gene in human cancers?

Evan H. Baugh et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Article Oncology

Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis

Patrick E. Nyman et al.

CLINICAL CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Molecular features of copper binding proteins involved in copper homeostasis

Giuseppe Inesi

IUBMB LIFE (2017)

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Review Cell Biology

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

Haitao Yu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

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Review Cell Biology

Necroptosis in development, inflammation and disease

Ricardo Weinlich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Review Chemistry, Multidisciplinary

Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53-MDM2 Interaction Useful in Targeted Cancer Therapy

Alpana K. Gupta et al.

TOPICS IN CURRENT CHEMISTRY (2017)

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Article Oncology

NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Cong-Fa Huang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

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Review Cell Biology

Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

TRENDS IN CELL BIOLOGY (2017)

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Article Cell Biology

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Yangchun Xie et al.

CELL REPORTS (2017)

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Article Multidisciplinary Sciences

Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo

Xiangxiang Hu et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

Emmanuelle Saint-Germain et al.

AGING-US (2017)

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Review Oncology

KRAS Alleles: The Devil Is in the Detail

Kevin M. Haigis

TRENDS IN CANCER (2017)

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Article Oncology

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

Jong-Lyel Roh et al.

CANCER LETTERS (2016)

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Article Oncology

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2

Danielle F. Eytan et al.

CANCER RESEARCH (2016)

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Article Oncology

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

Kevin D. McCormick et al.

CARCINOGENESIS (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Article Biochemistry & Molecular Biology

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi et al.

EMBO JOURNAL (2016)

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Article Biochemistry & Molecular Biology

Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy

Insoon Chang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Oncology

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

Xavier Castellsague et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

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Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

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Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Review Oncology

Role of interleukin-6 in cancer progression and therapeutic resistance

Neeraj Kumari et al.

TUMOR BIOLOGY (2016)

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Article Cell Biology

Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils

Simone Wicki et al.

CELL DEATH & DISEASE (2016)

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Article Cell Biology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

Shang-Jui Wang et al.

CELL REPORTS (2016)

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Article Oncology

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

Xavier Castellsague et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Multidisciplinary Sciences

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

Zhi-Li Zhao et al.

SCIENTIFIC REPORTS (2016)

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Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

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Review Biochemistry & Molecular Biology

TP53: an oncogene in disguise

T. Soussi et al.

CELL DEATH AND DIFFERENTIATION (2015)

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Article Oncology

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCI-1 and XIAP Antiapoptotic Proteins

Noriaki Tanaka et al.

CLINICAL CANCER RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia

Minal J. Menezes et al.

HUMAN MOLECULAR GENETICS (2015)

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Review Biochemistry & Molecular Biology

Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy

Yu Qiu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Multidisciplinary Sciences

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma

Yi Sun et al.

PLOS ONE (2015)

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Article Oncology

Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis

Li Zhang et al.

ONCOTARGET (2015)

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Article Biochemistry & Molecular Biology

Expression of xCT and activity of system X-c(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress

Eric Habib et al.

REDOX BIOLOGY (2015)

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Article Oncology

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Wei-Chieh Huang et al.

CANCER RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Michael J. White et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Anthony Rongvaux et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists

T. Yamazaki et al.

CELL DEATH AND DIFFERENTIATION (2014)

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Article Oncology

Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer

Russell Moser et al.

CLINICAL CANCER RESEARCH (2014)

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Review Biochemistry & Molecular Biology

The cytoplasmic side of p53′s oncosuppressive activities

Anna Comel et al.

FEBS LETTERS (2014)

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Article Oncology

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

Aurelie Morin et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Review Biochemistry & Molecular Biology

P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy

Ding-Guo Zhang et al.

MOLECULAR CANCER (2014)

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Article Biochemistry & Molecular Biology

NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)

Luciana O. Almeida et al.

FEBS OPEN BIO (2014)

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Article Oncology

Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer

Randall J. Kimple et al.

CANCER RESEARCH (2013)

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Article Biochemistry & Molecular Biology

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

F. Basit et al.

CELL DEATH AND DIFFERENTIATION (2013)

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Article Multidisciplinary Sciences

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

David M. Moquin et al.

PLOS ONE (2013)

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Article Oncology

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

Curtis R. Pickering et al.

CANCER DISCOVERY (2013)

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Article Oncology

Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

Vlad C. Sandulache et al.

CANCER (2012)

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Review Cell Biology

Autophagy: for better or for worse

Ellen Wirawan et al.

CELL RESEARCH (2012)

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Article Oncology

A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment

Hongzheng Zhang et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Article Oncology

Global Cancer Statistics

Ahmedin Jemal et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

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Review Oncology

Hypoxia-inducible factors in OSCC

Mario Perez-Sayans et al.

CANCER LETTERS (2011)

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Article Oncology

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe

Philip C. De Witt Hamer et al.

CLINICAL CANCER RESEARCH (2011)

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Article Cell Biology

Pancreatic cancers require autophagy for tumor growth

Shenghong Yang et al.

GENES & DEVELOPMENT (2011)

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Review Biotechnology & Applied Microbiology

The Role of HDAC6 in Cancer

Grace I. Aldana-Masangkay et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

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Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

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Article Multidisciplinary Sciences

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Nicolas Stransky et al.

SCIENCE (2011)

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Article Marine & Freshwater Biology

Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium

Gerhard Krumschnabel et al.

AQUATIC TOXICOLOGY (2010)

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Article Oncology

MK-1775, a small molecule Wee1 inhibitor, enhances antitumor efficacy of various DNA-damaging agents, including 5-fluorouracil

Hiroshi Hirai et al.

CANCER BIOLOGY & THERAPY (2010)

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Review Biochemistry & Molecular Biology

The Inflammasomes

Kate Schroder et al.

CELL (2010)

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Article Multidisciplinary Sciences

Stage-specific sensitivity to p53 restoration during lung cancer progression

David M. Feldser et al.

NATURE (2010)

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Review Oncology

IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

Mads Gyrd-Hansen et al.

NATURE REVIEWS CANCER (2010)

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Article Oncology

Overexpression of cFLIP in head and neck squamous cell carcinoma and its clinicopathologic correlations

Xiuguo Li et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2008)

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