Outcomes Among Mechanically Ventilated Patients With Severe Pneumonia and Acute Hypoxemic Respiratory Failure From SARS-CoV-2 and Other Etiologies

Article Pharmacology & Pharmacy

Sedation Usage in COVID-19 Acute Respiratory Distress Syndrome: A Multicenter Study

Natalie Tapaskar et al.

Summary: Patients with COVID-19 ARDS required higher doses of sedatives and benzodiazepines compared to those with non-COVID-19 ARDS to achieve similar sedation levels.

ANNALS OF PHARMACOTHERAPY (2022)

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Article Critical Care Medicine

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Michela Botta et al.

Summary: This national study in the Netherlands investigated the ventilation management of invasively ventilated patients with COVID-19 during the first month of the outbreak. Lung-protective ventilation with low tidal volume and prone positioning were common practices. The study provides valuable insights for future trials and interpretation of findings in this patient population.

LANCET RESPIRATORY MEDICINE (2021)

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Article Multidisciplinary Sciences

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Rogan A. Grant et al.

Summary: The study found that patients infected with SARS-CoV-2 have enriched T cells and monocytes in the alveolar space, suggesting that the virus infects alveolar macrophages and induces T cell production of interferon-, leading to inflammation and persistent alveolitis.

NATURE (2021)

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Article Critical Care Medicine

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Brenda T. Pun et al.

Summary: This study investigated the prevalence of delirium and coma in critically ill patients with COVID-19, identifying benzodiazepine use and lack of family visitation as modifiable risk factors for delirium. These findings present an opportunity to reduce acute brain dysfunction in patients with COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

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Article Critical Care Medicine

Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome: A Retrospective Cohort Study*

Karuna Wongtangman et al.

Summary: Compared to patients with acute respiratory distress syndrome of other causes, patients with COVID-19 received higher doses of hypnotics, leading to prolonged coma and higher mortality.

CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Coronavirus Disease 2019 Policy Restricting Family Presence May Have Delayed End-of-Life Decisions for Critically Ill Patients

Tej D. Azad et al.

Summary: The study found that restrictive visitor policies may lead to longer ICU stays and delay decisions to limit treatment for inpatients. Further policy evaluation and programs enabling access to family-centered care and palliative care during the ongoing coronavirus disease pandemic are crucial.

CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Lieuwe D. J. Bos et al.

Summary: This study aimed to identify respiratory subphenotypes of COVID-19-related ARDS using data-driven approaches. While no consistent subphenotypes were identified at baseline, two distinct subphenotypes were found during the first 4 days of invasive mechanical ventilation. These subphenotypes demonstrated differences in patient outcomes, indicating the importance of subtyping in the progression and outcomes of ARDS patients.

LANCET RESPIRATORY MEDICINE (2021)

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Article Critical Care Medicine

Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids

Pratik Sinha et al.

Summary: This study identified two distinct subgroups in COVID-19-related ARDS with different outcomes, which overlapped with previously described ARDS subphenotypes. The SARS-CoV-2 PCR cycle threshold had differential predictive value for mortality in the subphenotypes, and there were differential treatment responses to corticosteroids between the subphenotypes.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Respiratory System

Comparing Clinical Features and Outcomes in Mechanically Ventilated Patients with COVID-19 and Acute Respiratory Distress Syndrome

Michael W. Sjoding et al.

Summary: A retrospective cohort study comparing severe COVID-19 patients with non-COVID-19 ARDS patients found small differences in respiratory physiology and clinical outcomes between the two groups. The 28-day mortality rate was slightly lower in COVID-19 patients compared to non-COVID-19 ARDS patients. Further studies are needed to confirm these findings and define COVID-19-specific pathophysiology before changes in treatment practices can be recommended.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

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Article Critical Care Medicine

Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome

Francois Beloncle et al.

Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.

CRITICAL CARE (2021)

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Article Respiratory System

COVID-19 versus Non-COVID-19 Acute Respiratory Distress Syndrome Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers, and Clinical Outcomes

William Bain et al.

Summary: COVID-19 ARDS and ARDS from other etiologies have differences in demographic, physiologic parameters, and clinical outcomes, such as IL-6 levels and minute ventilation. Despite some similarities, COVID-19 ARDS shows longer duration of mechanical ventilation compared to other ARDS patients.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

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Article Respiratory System

Comparison of Clinical Features and Outcomes in Critically III Patients Hospitalized with COVID-19 versus Influenza

Natalie L. Cobb et al.

Summary: The study compared critically ill patients with COVID-19 and influenza, finding that patients with COVID-19 had a higher risk of mortality compared to patients with influenza. Although the clinical presentations were similar, patients with COVID-19 had differences in the need for mechanical ventilation, oxygenation improvement, and in-hospital mortality rates compared to patients with influenza.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

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Article Critical Care Medicine

Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study

Benoit Vandenbunder et al.

Summary: In COVID-19-related ARDS, Crs does not seem to have a significant impact on patient outcomes, while plateau pressure may be associated with the chance of breathing independently. In some patients, a decrease in Crs between day 1 and day 14 is observed, but this change does not affect the outcome on day 28.

CRITICAL CARE (2021)

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Article Critical Care Medicine

Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study

Matthieu Schmidt et al.

Summary: Among more than 4000 critically ill patients with COVID-19 admitted to our ICUs, 90-day mortality was 31% and decreased from 42 to 25% over the study period. Mortality was higher in older, diabetic, obese and severe ARDS patients.

INTENSIVE CARE MEDICINE (2021)

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Letter Critical Care Medicine