期刊
BIOENGINEERING & TRANSLATIONAL MEDICINE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/btm2.10470
关键词
cellulose nanocrystal; chemodynamic therapy; hybrid gel network; Laponite; photothermal therapy
资金
- Korea Basic Science Institute (National Research Facilities and Equipment Center) - Ministry of Education [2022R1A6C101A739]
- National Research Foundation of Korea [2018R1A6A1A03025582, 2020R1C1C1003945]
- National Research Foundation of Korea [2022R1A6C101A739, 2020R1C1C1003945] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A hybrid gel based on organic nanorod and inorganic nanodisk was developed for localized cancer therapy. The gel demonstrated significant tumor suppression effects and induced cellular apoptosis.
Indocyanine green (ICG), glucose oxidase (GOx), and copper(II) sulfate (Cu)-installed hybrid gel based on organic nanorod (cellulose nanocrystal [CNC]) and inorganic nanodisk (Laponite [LAP]) was developed to perform a combination of starvation therapy (ST), chemodynamic therapy (CDT), and photothermal therapy (PTT) for localized cancers. A hybrid CNC/LAP network with a nematic phase was designed to enable instant gelation, controlled viscoelasticity, syringe injectability, and longer in vivo retention. Moreover, ICG was introduced into the CNC/LAP gel system to induce hyperthermia of tumor tissue, amplifying the CDT effect; GOx was used for glucose deprivation (related to the Warburg effect); and Cu was introduced for hydroxyl radical generation (based on Fenton-like chemistry) and cellular glutathione (GSH) degradation in cancer cells. The ICG/GOx/Cu-installed CNC/LAP gel in combination with near-infrared (NIR) laser realized improved antiproliferation, cellular reactive oxygen species (ROS) generation, cellular GSH degradation, and apoptosis induction in colorectal cancer (CT-26) cells. In addition, local injection of the CNC/ICG/GOx/Cu/LAP gel into the implanted CT-26 tumor while irradiating it with NIR laser provided strong tumor growth suppression effects. In conclusion, the designed hybrid nanorod/nanodisk gel network can be efficiently applied to the local PTT/ST/CDT of cancer cells.
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