☆ 4.7 Review

Recent advances in activatable NIR-II organic fluorophores for biomedical applications

MATERIALS CHEMISTRY FRONTIERS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Yishen Liu et al.

Summary: In vivo imaging in the second near-infrared window (NIR-II) has provided great opportunities for biomedical research and clinical applications. This review summarizes the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. The versatile applications and imaging modalities enabled by these advanced fluorescent properties are discussed, along with the challenges and perspectives for future clinical translation to boost the progress of NIR-IIa and NIR-IIb imaging technology.

CHEMICAL REVIEWS (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Activatable molecular probes for fluorescence-guided surgery, endoscopy and tissue biopsy

Yan Zhang et al.

Summary: Activatable molecular probes have shown great potential in surgical imaging and diagnosis by offering high target-to-background ratios with high specificity and sensitivity through turning on their signals upon reaction with targeted biomolecules. They not only ensure complete resection of malignant tissues, but also better preservation of vital organs and tissues during surgical procedures.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Recent advances in multifunctional fluorescent probes for viscosity and analytes

Xiaopeng Yang et al.

Summary: Viscosity plays a crucial role in biological systems and its abnormality is closely related to the development of diseases in cellular microenvironment. Fluorescence imaging, with its excellent sensitivity, non-invasive detection, high selectivity and real-time imaging, has become a powerful tool for monitoring local microviscosity and analytes changes in living cells. This review focuses on the design strategies, spectral performance, and biological applications of multifunctional probes for simultaneous detection of viscosity and analytes, and proposes new ideas to overcome the limitations of existing probes.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Review Materials Science, Multidisciplinary

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR-II Fluorophores

Zhaohui Wang et al.

Summary: The review provides an overview of the development and construction of organic NIR-II fluorophores, with a focus on summarizing and discussing modulation strategies to improve their performance and functionality. The conclusion and future directions of the modulation strategy are also presented in detail.

ADVANCED OPTICAL MATERIALS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer

Yingying Li et al.

Summary: This study develops CuInSe2@ZnS:Mn quantum dots with intrinsic multifunctionality, which can accurately localize small metastases and act as potent tumor ablation agents.

ACS NANO (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer

Yi Lai et al.

Summary: In this study, a near-infrared II (NIR-II) fluorescence nanotheranostic system activated by methylglyoxal (MGO) was developed for cancer therapy. The system showed highly specific activation in tumors and achieved combinatory therapy through photothermal and photodynamic effects.

ADVANCED FUNCTIONAL MATERIALS (2022)

添加到收藏夹

Article Chemistry, Analytical

An activatable probe for detection and therapy of food-additive-related hepatic injury via NIR-II fluorescence/optoacoustic imaging and biomarker-triggered drug release

Cheng Zeng et al.

Summary: Food additives play an important role in ensuring the safety of processed foods, but nitrites can generate toxic nitrosamines, causing liver damage. This study presents an activatable probe for detecting nitrosamine-induced acute liver injury and releasing drugs for therapy.

ANALYTICA CHIMICA ACTA (2022)

添加到收藏夹

Article Engineering, Biomedical

An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome

Lihe Sun et al.

Summary: In this study, an oral-administration nanosystem (QM@EP) for the detection, targeted delivery, and therapy of ulcerative colitis was developed. The nanosystem successfully delivered the probe and drug to the colon and released them upon the stimulation of colonic pH. The released probe exhibited strong fluorescence for imaging and the released drug showed high therapeutic efficacy against ulcerative colitis.

BIOMATERIALS (2022)

添加到收藏夹

Article Nanoscience & Nanotechnology

In vivo non-invasive confocal fluorescence imaging beyond 1,700 nm using superconducting nanowire single-photon detectors

Feifei Wang et al.

Summary: By studying light scattering and utilizing new materials technology, the imaging depth of high-resolution optical microscopy in live mammals can be improved. This study demonstrates single-photon excitation fluorescence imaging in the NIR-IIc range, achieving the longest single-photon excitation and emission wavelengths to date for in vivo imaging of mice.

NATURE NANOTECHNOLOGY (2022)

添加到收藏夹

Review Oncology

pH-Responsive Polymer Nanomaterials for Tumor Therapy

Shunli Chu et al.

Summary: The complexity of the tumor microenvironment can be overcome by using pH-responsive polymers for targeted drug delivery, improving treatment efficacy and reducing adverse reactions.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Chemistry, Analytical

Aminopeptidase N Activatable Nanoprobe for Tracking Lymphatic Metastasis and Guiding Tumor Resection Surgery via Optoacoustic/ NIR-II Fluorescence Dual-Mode Imaging

Junjie Chen et al.

Summary: Lymphatic metastasis plays a crucial role in cancer progression and is closely associated with recurrence and reduced survival. Tracking tumor lymphatic metastasis and imaging-guided resection surgery are important. In this study, an activatable nanoprobe is developed for precise tracking of lymphatic metastasis and imaging-guided surgery.

ANALYTICAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Precision Navigation of Hepatic Ischemia-Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-II Fluorescence

Jihong Liu et al.

Summary: This study developed a new fluorescent probe (NP-V) that can detect lysosomal viscosity in hepatocytes and mice during HIRI, and achieved precise resection of the lesion area. It has significant implications in early warning and treatment planning for HIRI.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Advances in Near-Infrared-II Fluorescence Imaging for Deep-Tissue Molecular Analysis and Cancer Diagnosis

Xiangdan Meng et al.

Summary: Fluorescence imaging with high sensitivity and minimal invasiveness has attracted great attention for visualized monitoring and evaluation of cancer progression. The second near-infrared (NIR-II) optical window provides deeper tissue penetration and higher temporal-spatial resolution, making it suitable for deep-tissue in vivo imaging and real-time monitoring of cancer development. Various multifunctional NIR-II fluorophores have been developed for sensitive in vivo imaging of biomarkers and visualization of cancer treatment. This review highlights the advantages of NIR-II fluorescence imaging in real-time visualization of tumors and cancer diagnosis, as well as its application in deep-tissue biomarker analysis and tumor tissue visualization.

SMALL (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Deep Learning Fluorescence Imaging of Visible to NIR-II Based on Modulated Multimode Emissions Lanthanide Nanocrystals

Yapai Song et al.

Summary: Fluorescence bioimaging is a hot topic in the field of life sciences and medicine. This study presents a method to modulate energy migration processes using lanthanide doped nanocrystals, enabling switchable emission modes of visible and NIR-II fluorescence. By combining multimode emissions and deep learning, a unique deep learning fluorescence bioimaging method is created.

ADVANCED FUNCTIONAL MATERIALS (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Xinyu Liu et al.

Summary: Near-infrared fluorescence imaging has gained attention in biomedical research due to its high sensitivity and specificity. Near-infrared II (NIR-II) fluorescence imaging further enhances the imaging effect by reducing tissue absorption, scattering, and autofluorescence. Organic small molecule fluorophores have shown promising potential as fluorescent probes. This review summarizes the latest progress in organic small molecule fluorescent probes for NIR-II imaging, including molecular structure, performance improvement methods, probe delivery in organisms, and their applications in biological imaging and tumor therapy.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Emerging NIR-II luminescent bioprobes based on lanthanide-doped nanoparticles: From design towards diverse bioapplications

Pengye Du et al.

Summary: The second near-infrared (NIR-II) fluorescence has promising applications in the biological field due to its ability for deep tissue penetration, weak tissue scattering, low autofluorescence, and high temporal and spatial resolution. Lanthanide-doped nanoparticles (LDNPs) are considered highly promising materials for optical bioprobes due to their unique optical properties such as long luminescence lifetimes, large Stokes or anti-Stokes shifts, narrow-band emission, and high resistance to photobleaching and blinking. The abundant loadable and modifiable sites on the surface of LDNPs offer good conditions for functional bioprobes construction. This review summarizes the common synthesis methods, strategies to enhance NIR-II luminescence, and surface functionalization modifications of LDNPs. It also provides an overview of recent research advances in optical sensing, bioimaging, and image-guided therapy using NIR-II luminescent LDNPs. Finally, the opportunities and challenges of NIR-II luminescent bioprobes based on LDNPs in bioapplications are discussed.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Activatable NIR-II organic fluorescent probes for bioimaging

Xiaoning Zhang et al.

Summary: NIR-II imaging technology has made significant progress in diagnosing diseases with its high resolution and deep tissue penetration capabilities. Activatable NIR-II fluorescence probes show great potential in reporting pathological changes, exhibiting tunable properties and excellent biocompatibility.

THERANOSTICS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Refashioning benzothiadiazole dye as an activatable nanoprobe for biomarker detection with NIR-II fluorescence/optoacoustic imaging

Junjie Chen et al.

Summary: Endogenous nitric oxide plays an important role in living beings, making accurate and non-invasive detection of nitric oxide crucial. This study presents an activatable nanoprobe, BNDA@H beta CD, for detecting nitric oxide using aggregation-induced emission. The probe forms nanoaggregates in aqueous media and generates activated probe upon reaction with nitric oxide, resulting in strong NIR-II fluorescence emission and optoacoustic signals. BNDA@H beta CD can detect liver injury and monitor therapeutic outcome in a mouse model, as well as image nitric oxide in soybean sprouts. The results demonstrate that BNDA@H beta CD is a powerful tool for nitric oxide detection in both animals and plants.

CELL REPORTS PHYSICAL SCIENCE (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

NIR-II AIEgens: A Win-Win Integration towards Bioapplications

Wenhan Xu et al.

Summary: NIR-II AIEgens enabled by aggregation-induced emission luminogens have emerged as a promising field for high-performance imaging, overcoming limitations in penetration depth and fluorescence efficiency. Some NIR-II AIEgens demonstrate dual-mode imaging capabilities and guided photothermal therapy, improving diagnostic accuracy and providing an efficient platform for theranostics. This review highlights recent efforts in exploiting NIR-II AIEgens, discussing molecular design strategies, bioapplications, and presenting current challenges and future prospects for diverse applications.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Molecular Engineering of NIR-II Fluorophores for Improved Biomedical Detection

Zuhai Lei et al.

Summary: The development of fluorophores for the NIR-II window is a significant and vibrant field in chemistry, biology, and engineering, with wavelength, brightness, and stability being crucial factors. Progress has been made in synthesizing D-A-D and D-pi-A fluorophores, as well as constructing off-on and ratiometric probes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A General Strategy for Development of Activatable NIR-II Fluorescent Probes for In Vivo High-Contrast Bioimaging

Tian-Bing Ren et al.

Summary: Organic dye based NIR-II fluorescent probes offer high signal-to-background ratio and deep-tissue imaging capabilities. A novel class of polymethine dyes, NIRII-RTs, with bright and stable NIR-II emission and large Stokes shifts have been designed. These dyes, particularly NIRII-RT3 and NIRII-RT4, can serve as effective platforms for activatable bioimaging probes. Target-activatable NIRII-RT probes for pH, ATP, and metal-ion detection were synthesized, demonstrating real-time monitoring of drug-induced hepatotoxicity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Endogenous H2S-Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for In Situ Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury

Zhiming Deng et al.

Summary: The hypoglycemic drug metformin has shown potential for treating various diseases beyond diabetes, but overdose can lead to serious liver injury. Developing intelligent NIR-II emitting nanoprobes using endogenous H2S as a trigger for monitoring metformin-induced hepatotoxicity is desirable, and a specific probe has been successfully designed for in situ ratiometric monitoring.

ACS NANO (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing

Xin Zhang et al.

Summary: This study introduces a dual activatable fluorescent probe PN910, which shows high selectivity toward H2O2 and OONO- at pH beyond 7.4 in alkaline tissue. It can be used for real-time, specific, and accurate monitoring of cystitis and colitis in living animals, presenting a unique approach for in vivo biosensing with a dual activatable probe.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter

Tianli Zhu et al.

Summary: This study presents the design and synthesis of a dually responsive reporter for detecting the dynamic presence of NO and H2S in living cells. By cycling S-nitrosation and transnitrosation reactions, the designed reporter allows interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H2S). Water-soluble BOD-NH-SC dots were synthesized for visualizing the intracellular dynamics of NO and H2S, providing a toolbox to elucidate the interplaying roles of these gasotransmitters in various signal transduction pathways.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

NIR-II pH Sensor with a FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization

Mengyao Zhao et al.

Summary: The newly developed pTAS sensors can achieve high sensitivity tumor pH monitoring within a wider response region, extending the pH detection range. Through dual-channel ratiometric bioimaging, the dynamic changes in tumor pH can be visualized in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Cell Biology

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

Daqian Xu et al.

Summary: Key pathological signaling pathways regulate metabolic enzymes, giving them nonmetabolic functions. These aberrantly regulated metabolic enzymes play critical roles in governing cellular activities, promoting disease progression.

CELL METABOLISM (2021)

添加到收藏夹

Article Chemistry, Applied

Molecular design of fluorescent pH sensors based on reduced rhodol by structure-pKa relationship for imaging of lysosome

Kunal N. More et al.

Summary: Maintaining pH-homeostasis is crucial for cell survival, as abnormal pH in lysosomes can lead to various diseases. A series of novel pH-sensitive fluorescent sensors were developed based on a structure-pKa relationship study, showing potential for monitoring acidic lysosomes.

DYES AND PIGMENTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Kinetic Study on the Reactivity of Azanone (HNO) toward Cyclic C-Nucleophiles

Angelika Artelska et al.

Summary: The study investigates the reactivity of the elusive electrophilic reactive nitrogen species, HNO, towards various cyclic C-nucleophiles under aqueous conditions. Results demonstrate a strong dependence of HNO reactivity on the structure of the scavenger. Comprehensive discussion accompanied by quantum mechanical calculations sheds light on the reaction between HNO and C-nucleophiles.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Analytical

Ambient Oxygen-Doped Conjugated Polymer for pH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window

Jiayingzi Wu et al.

Summary: This study presents a pH-activatable and aggregation-enhanced NIR-II PA probe, utilizing oxygen-doped polymer to achieve water-solubility at physiological pH and aggregation in acidic environment for enhanced PA signal. The probe shows promise for specific diagnosis of acidic tumor microenvironment in vivo and paves the way for new activatable NIR-II imaging probes.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Analytical

Flexible Designing Strategy to Construct Activatable NIR-II Fluorescent Probes with Emission Maxima beyond 1200 nm

Kun Dou et al.

Summary: An approach to modulate the emission wavelength of NIR-II fluorescent probes by elongating the pi-conjugated system and enhancing the electron-donating ability of the donor region was proposed, resulting in the development of four proof-of-concept probes with emission maxima ranging from 925 to 1205 nm. Among these probes, WH-3 exhibited high sensitivity towards H2S and enabled in vivo tracking and imaging of H2S with high contrast. This molecular design strategy shows promise in developing activatable NIR-II fluorescent probes with long emission.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Junjie Chen et al.

Summary: The research team developed an activatable nanoprobe by linking a benzothiadiazole core with specific groups, which can be cleaved and activated at disease sites, generating fluorescent emission and ultrasound signal for multi-mode imaging for detection and imaging.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Promising NIR-II Fluorescent Sensor for Peptide-Mediated Long-Term Monitoring of Kidney Dysfunction

Ying Chen et al.

Summary: The research demonstrates a strategy for peptide-mediated delivery of fluorophores into the kidney for precise diagnosis of renal diseases. Additionally, a sensor designed for long-term kidney monitoring and urine analysis plays a crucial role in detecting early kidney injury and reporting on kidney dysfunctional progression.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Engineering, Biomedical

NIR-II bioimaging of small organic molecule

Yingbin Su et al.

Summary: In recent years, there has been an active exploration of new imaging methods with high biological imaging performance, particularly in the NIR-II region. The use of small organic molecule fluorophores has attracted attention due to their good biocompatibility properties, showing promise for future developments in imaging research.

BIOMATERIALS (2021)

添加到收藏夹

Review Chemistry, Medicinal

Activatable NIR-II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

Liang Gong et al.

Summary: Activatable fluorescent probes have gained extensive attention in the field of bioimaging and biosensing due to their responsiveness to biological targets. The development of second near-infrared window (NIR-II) fluorescent materials provides new opportunities for activatable fluorescent probes. This paper summarizes the properties, advantages, and disadvantages of mainly NIR-II fluorophores, and discusses the current role and development of activatable NIR-II fluorescent probes for biomedical applications, along with potential challenges and perspectives in deep-tissue imaging and clinical applications.

CHEMMEDCHEM (2021)

添加到收藏夹

Review Chemistry, Analytical

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Dong Li et al.

Summary: Recently, activatable NIR-II fluorescent probes have shown to have specific targeting to biological tissues, providing higher imaging signal-to-background ratio and lower detection limit. Utilizing disease-associated endogenous stimuli to activate NIR-II probes is significant for achieving switchable fluorescent signals for specific deep bioimaging applications. Challenges and perspectives of activatable NIR-II fluorescent probes are also discussed in this review.

BIOSENSORS-BASEL (2021)

添加到收藏夹

Article Chemistry, Analytical

A Fast-Responsive OFF-ON Near-Infrared-II Fluorescent Probe for In Vivo Detection of Hypochlorous Acid in Rheumatoid Arthritis

Peng Wu et al.

Summary: The study introduced an OFF-ON NIR-II fluorescent probe named PTA for imaging HClO in deep-seated early RA, showing good water solubility, high photostability, and rapid response capability. The probe was able to sensitively and specifically detect HClO both in exogenous and endogenous sources, with promising potential for diagnosis of HOCl-mediated inflammatory disorders.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Engineering, Biomedical

An Activatable Probe with Aggregation-Induced Emission for Detecting and Imaging Herbal Medicine Induced Liver Injury with Optoacoustic Imaging and NIR-II Fluorescence Imaging

Lihe Sun et al.

Summary: This study demonstrates an activatable probe QY-N for diagnosing herbal-medicine-induced liver injury by detecting hepatic NO with NIR-II fluorescence and multispectral optoacoustic tomography (MSOT) imaging. Experimental results show that the probe can be successfully used to detect herbal-medicine-induced liver injury and monitor the rehabilitation of liver injury during treatment.

ADVANCED HEALTHCARE MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging

Longqi Chen et al.

Summary: A turn-on optoacoustic and NIR-II fluorescent probe, TC-H2O2, has been developed for imaging antituberculotic drug-induced liver injury. The probe responds to hepatic H2O2, releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.

CHEMICAL COMMUNICATIONS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Fluorescence imaging of pathophysiological microenvironments

Shan Wang et al.

Summary: Abnormal microenvironments play a significant role in various pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. Fluorescence imaging has emerged as a powerful tool for tracking changes in pathophysiological microenvironments, offering promising prospects for future development and application in fluorescent probes.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Boosting the AIEgen-based photo-theranostic platform by balancing radiative decay and non-radiative decay

Yanzi Xu et al.

Summary: This study developed a new molecule DTPA-BBTD to balance the radiative decay and non-radiative decay pathways, which provides a single-molecule-triggered photo-theranostic platform. The molecule was successfully applied for fluorescence imaging and photoacoustic imaging, and tumor growth was inhibited through photothermal therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Constitutional Isomerization Enables Bright NIR-II AIEgen for Brain-Inflammation Imaging

Shunjie Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

添加到收藏夹

Article Chemistry, Analytical

Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations

Kun Dou et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoaggregate Probe for Breast Cancer Metastasis through Multispectral Optoacoustic Tomography and Aggregation-Induced NIR-I/II Fluorescence Imaging

Juan Ouyang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Review Biochemical Research Methods

Activatable Fluorescence Probes for Turn-On and Ratiometric Biosensing and Bioimaging: From NIR-I to NIR-II

Chuan Chen et al.

BIOCONJUGATE CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Physical

Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness

Huilong Ma et al.

CHEMISTRY OF MATERIALS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

Luyan Wu et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Analytical

Single Wavelength Laser Excitation Ratiometric NIR-II Fluorescent Probe for Molecule Imaging in Vivo

Xiaoguang Ge et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Yuanyuan Li et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Urology & Nephrology

A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure

Zhi Yu et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Chemistry, Analytical

Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging

Zhuo Zeng et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Recent advances in the development of NIR-II organic emitters for biomedicine

Jun Li et al.

COORDINATION CHEMISTRY REVIEWS (2020)

添加到收藏夹

Article Immunology

Redox homeostasis maintained by GPX4 facilitates STING activation

Mutian Jia et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Near-Infrared-II Fluorescence Probes Based on Organic Small Molecules

Sang Ruoyu et al.

ACTA CHIMICA SINICA (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tuning molecular aggregation to achieve highly bright AIE dots for NIR-II fluorescence imaging and NIR-I photoacoustic imaging

Yanzi Xu et al.

CHEMICAL SCIENCE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

Ji-An Chen et al.

CHEMICAL COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

Yang Li et al.

CHEMICAL SCIENCE (2020)

添加到收藏夹

Article Chemistry, Analytical

Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring

Dandan Li et al.

ANALYTICAL CHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Shangfeng Wang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Carbogenic Nanozyme with Ultrahigh Reactive Nitrogen Species Selectivity for Traumatic Brain Injury

Xiaoyu Mu et al.

NANO LETTERS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

Luling Wu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nitric Oxide-Activated Dual-Key-One-Lock Nanoprobe for in Vivo Molecular Imaging and High-Specificity Cancer Therapy

Lili Teng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Review Materials Science, Multidisciplinary

Recent Advances on Activatable NIR-II Fluorescence Probes for Biomedical Imaging

Yufu Tang et al.

ADVANCED OPTICAL MATERIALS (2019)

添加到收藏夹

Article Chemistry, Analytical

Lighting Up NIR-II Fluorescence in Vivo: An Activable Probe for Noninvasive Hydroxyl Radical Imaging

Wenqi Feng et al.

ANALYTICAL CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Caixia Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Analytical

A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells

Xueluer Mu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop

Jiancheng Wang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bio-Erasable Intermolecular Donor-Acceptor Interaction of Organic Semiconducting Nanoprobes for Activatable NIR-II Fluorescence Imaging

Yufu Tang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Yue Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Lock-and-Key-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window

Yufu Tang et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission

Ge Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Development of endogenous enzyme-responsive nanomaterials for theranostics

Jing Mu et al.

CHEMICAL SOCIETY REVIEWS (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

Shuqing He et al.

CHEMICAL SOCIETY REVIEWS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

Qinglai Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

Feng Ding et al.

CHEMICAL SCIENCE (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy

Ben Shi et al.

NANO LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

Nuernisha Alifu et al.

ACS NANO (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window

Chunyan Li et al.

ACS NANO (2018)

添加到收藏夹

Review Chemistry, Analytical

Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems

Xiaoyun Jiao et al.

ANALYTICAL CHEMISTRY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy

Xiaoqing Meng et al.

THERANOSTICS (2018)

添加到收藏夹

Article Chemistry, Analytical

Single Fluorescent Probe for Dual-Imaging Viscosity and H2O2 in Mitochondria with Different Fluorescence Signals in Living Cells

Mingguang Ren et al.

ANALYTICAL CHEMISTRY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells

Longwei He et al.

CHEMICAL SCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Alexander L. Antaris et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

Yan Lyu et al.

ADVANCED SCIENCE (2017)

添加到收藏夹

Review Engineering, Biomedical

Near-infrared fluorophores for biomedical imaging

Guosong Hong et al.

NATURE BIOMEDICAL ENGINEERING (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling

Nithya Velusamy et al.

CHEMICAL COMMUNICATIONS (2017)

添加到收藏夹

Article Chemistry, Analytical

Investigation of Drug-Induced Hepatotoxicity and Its Remediation Pathway with Reaction-Based Fluorescent Probes

Dan Cheng et al.

ANALYTICAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Physical

A small-molecule dye for NIR-II imaging

Alexander L. Antaris et al.

NATURE MATERIALS (2016)

添加到收藏夹

Article Chemistry, Analytical

Rational Design of an α-Ketoamide-Based Near-Infrared Fluorescent Probe Specific for Hydrogen Peroxide in Living Systems

Xilei Xie et al.

ANALYTICAL CHEMISTRY (2016)

添加到收藏夹

Article Engineering, Biomedical

Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines

Junfeng Miao et al.

BIOMATERIALS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

A sensitive fluorescent sensor for the detection of endogenous hydroxyl radicals in living cells and bacteria and direct imaging with respect to its ecotoxicity in living zebra fish

Fei Liu et al.

CHEMICAL COMMUNICATIONS (2016)

添加到收藏夹

Article Chemistry, Analytical

A fast-responsive turn on fluorescent probe for detecting endogenous hydroxyl radicals based on a hybrid carbazole-cyanine platform

Jian-Yong Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects

Jingye Zhang et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

NIR in, far-red out: developing a two-photon fluorescent probe for tracking nitric oxide in deep tissue

Zhiqiang Mao et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Simultaneous fluorescence imaging of hydrogen peroxide in mitochondria and endoplasmic reticulum during apoptosis

Haibin Xiao et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery

Kewei Ren et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Development of an AND Logic-Gate-Type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy

Ippei Takashima et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

Deju Ye et al.

NATURE CHEMISTRY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Activatable Rotor for Quantifying Lysosomal Viscosity in Living Cells

Lu Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria

Zhigang Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multifunctional in vivo vascular imaging using near-infrared II fluorescence

Guosong Hong et al.

NATURE MEDICINE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window

Kevin Welsher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Nanoscience & Nanotechnology

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

Kevin Welsher et al.

NATURE NANOTECHNOLOGY (2009)

添加到收藏夹

Review Multidisciplinary Sciences

Imaging in the era of molecular oncology

Ralph Weissleder et al.

NATURE (2008)

添加到收藏夹

Review Cell Biology

ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis

Benoit D'Autreaux et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

添加到收藏夹

Article Chemistry, Physical

Novel cyanine dyes as fluorescent pH sensors: PET, ICT mechanism or resonance effect?

Yufang Xu et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2007)

添加到收藏夹

Review Oncology

Exploiting tumour hypoxia in cancer treatment

JM Brown et al.

NATURE REVIEWS CANCER (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

In vivo near-infrared fluorescence imaging

JV Frangioni

CURRENT OPINION IN CHEMICAL BIOLOGY (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

A structural view of the action of Escherichia coli (lacZ) β-galactosidase

DH Juers et al.

BIOCHEMISTRY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.