Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation

Our findings demonstrate that glycolytic activity is neces-sary to maintain intestinal stem cell (ISC) self-renewal and that limiting glycolysis contributes to the generation of secretory lineages from ISCs. The inability to fine-tune glycolysis in ISCs subsequently disturbs the balance be-tween self-renewal and differentiation.

Automated summary

Our findings indicate that glycolytic activity is essential for maintaining the self-renewal of intestinal stem cells (ISCs), and inhibiting glycolysis contributes to the differentiation of secretory lineages from ISCs. The dysregulation of glycolysis in ISCs disrupts the balance between self-renewal and differentiation.