4.4 Article

Corticotropin releasing factor neurons in the visual cortex mediate long-term changes in visual function induced by early adversity

期刊

NEUROBIOLOGY OF STRESS
卷 21, 期 -, 页码 -

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2022.100504

关键词

Corticotropin-releasing factor (CRF) neurons; Chemogenetic; Ocular dominance; Neuronal activity; Stress system and visual system

资金

  1. National Natural Science Foundation of China [31871054, 81870869, 41030830]
  2. Open Research Funds of State Key Laboratory of Ophthalmology [2022KF03]

向作者/读者索取更多资源

Early adversity can lead to dysfunction of the visual system in adulthood, but female mice subjected to early chronic mild stress (ECMS) can maintain ocular dominance (OD) plasticity. The CRF-CRFR1 system within the primary visual cortex (V1) may mediate the long-term effect of early stress on visual plasticity and provide a target for the prevention of visual deficits in adults.
Early adversity can cause malfunction of the visual system in adulthood. Adult female but not male mice undergoing early chronic mild stress (ECMS) maintain ocular dominance (OD) plasticity after the critical period. How early stressful experiences have a long-term impact on it is largely unknown. Here, we observed a wide distribution of corticotropin-releasing factor (CRF)-positive neurons, which mainly colocalized with a subpopulation of GABAergic interneurons in the mouse primary visual cortex (V1). Optogenetic activation of CRF-positive neurons transfected with AAV-ChR2 evoked inhibitory currents in nearby pyramidal cells. ECMS induced a reduction in the expression of CRF mRNA in adult mouse V1. Chemogenetic activation of V1 CRF neurons impaired OD plasticity in adult ECMS females. We further showed that local administration of the corticotropin releasing factor receptor 1 (CRFR1) antagonist via an osmotic minipump into the visual cortex mimicked OD plasticity in adult ECMS females. Whole-cell recording in layer 2/3 pyramidal neurons revealed that the CRFR1 antagonist reduced the short-term depression (STD) of evoked inhibitory postsynaptic current (IPSC) in females but not in males. Likewise, CRF agonists have the opposite effect. In summary, our findings indicate that the local CRF-CRFR1 system within V1 may mediate the long-term and sex-dependent effect of early stress experiences on visual plasticity and provide a target for the prevention of visual deficits in adults with a history of early-life adversity.

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