4.7 Article

MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Diverse alterations associated with resistance to KRAS(G12C) inhibition

Yulei Zhao et al.

Summary: Resistance to KRAS(G12C) inhibitors demonstrates a heterogeneous pattern with multiple subclonal events emerging during treatment. Co-targeting of ERK signaling intermediates can enhance the antiproliferative effect of G12C inhibitor treatment in models with acquired RAS or BRAF mutations.

NATURE (2021)

Article Genetics & Heredity

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

Takahiro Ito et al.

Summary: Research using a CRISPR paralog targeting library identified that dual inactivation of DUSP4 and DUSP6 selectively impairs growth in NRAS and BRAF mutant cells. Cells resistant to MAPK pathway therapeutics become cross-sensitized to DUSP4 and DUSP6 perturbations, reinforcing the mechanisms of resistance to the inhibitors.

NATURE GENETICS (2021)

Article Oncology

Clinical Acquired Resistance to KRASG12C Inhibition through a novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

Noritaka Tanaka et al.

Summary: This study described a patient with KRAS(G12C) non-small cell lung cancer who developed polyclonal acquired resistance to MRTX849 treatment. The research identified 10 heterogeneous resistance alterations that converged to reactivate the RAS-MAPK signaling pathway. Additionally, a novel KRAS(Y96D) mutation affecting key protein-drug interactions and driving resistance was discovered.

CANCER DISCOVERY (2021)

Article Medicine, General & Internal

Acquired Resistance to KRASG12C Inhibition in Cancer

M. M. Awad et al.

Summary: A study of 38 patients with KRAS(G12C)-mutant cancers treated with adagrasib revealed diverse mechanisms of acquired resistance in 45% of them, including various mutations and bypass mechanisms. New therapeutic strategies are needed to overcome this drug resistance.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Jenny Y. Xue et al.

NATURE (2020)

Article Medicine, General & Internal

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

David S. Hong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer

Juergen Wolf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma

Grace P. Leung et al.

MOLECULAR CANCER RESEARCH (2019)

Review Oncology

New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness

Haitang Yang et al.

FRONTIERS IN ONCOLOGY (2019)

Article Multidisciplinary Sciences

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon et al.

NATURE (2019)

Review Multidisciplinary Sciences

A view on drug resistance in cancer

Neil Vasan et al.

NATURE (2019)

Review Oncology

Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy

Ferdinandos Skoulidis et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

Trametinib downregulates survivin expression in RB1-positive KRASmutant lung adenocarcinoma cells

Toshiyuki Sumi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

Chiara Ambrogio et al.

Article Medicine, General & Internal

Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer

J. -C. Soria et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

Xiangjun Kong et al.

NATURE (2017)

Article Multidisciplinary Sciences

A combinatorial strategy for treating KRAS-mutant lung cancer

Eusebio Manchado et al.

NATURE (2016)

Article Medicine, General & Internal

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Mark G. Kris et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)

Article Multidisciplinary Sciences

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Chong Sun et al.

NATURE (2014)

Article Cell Biology

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence

Jimin Shin et al.

CELLULAR SIGNALLING (2013)

Review Oncology

TGF-beta signaling and epithelial-mesenchymal transition in cancer progression

Yoko Katsuno et al.

CURRENT OPINION IN ONCOLOGY (2013)

Article Multidisciplinary Sciences

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Meghna Das Thakur et al.

NATURE (2013)

Article Medicine, General & Internal

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

Alice T. Shaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Oncology

STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

Bingbing Dai et al.

CANCER RESEARCH (2011)

Article Multidisciplinary Sciences

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

Kristen L. Meerbrey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Oncogenic Activating Mutations Are Associated with Local Copy Gain

Barmak Modrek et al.

MOLECULAR CANCER RESEARCH (2009)

Article Multidisciplinary Sciences

Somatic mutations affect key pathways in lung adenocarcinoma

Li Ding et al.

NATURE (2008)

Article Multidisciplinary Sciences

Characterizing the cancer genome in lung adenocarcinoma

Barbara A. Weir et al.

NATURE (2007)

Review Biochemistry & Molecular Biology

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P. J. Roberts et al.

ONCOGENE (2007)

Review Biochemistry & Molecular Biology

MAP kinase signalling pathways in cancer

A. S. Dhillon et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Y Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)