期刊
BIOACTIVE MATERIALS
卷 19, 期 -, 页码 88-102出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.03.038
关键词
Mosaicplasty; Osteochondral integration; Bioactive supramolecular nanofiber; GelMA hydrogel; Tissue engineering
This study developed a strategy to enhance integration of the gap region following mosaicplasty by applying BSN-GelMA hydrogel. The results showed that BSN-GelMA achieved seamless osteochondral healing in the gap region, with improved cartilage repair scores, glycosaminoglycan content, subchondral bone volume, and collagen II expression. This study provides a powerful approach to improve gap integration after autologous mosaicplasty and offers a promising bioactive material for cell-free tissue regeneration.
Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice. Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface, graft necrosis and sclerosis. However, poor gap integration is a serious concern, which eventually leads to deterioration of joint function. To deal with such complications, this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl (GelMA) hydrogel (BSN-GelMA). A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty, as early as six weeks. Moreover, the International Cartilage Repair Society score, histology score, glycosaminoglycan content, subchondral bone volume, and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated group. This improved outcome was due to bio-interactive materials, which acted as tissue fillers to bridge the gap, prevent cartilage degeneration, and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA hydrogel. This study provides a powerful and applicable approach to improve gap integration after autologous mosaicplasty. It is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration.
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