期刊
SMALL METHODS
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.202201403
关键词
immunogenic cell death; metal-based photosensitizers; photodynamic immunotherapy; photodynamic therapy
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars
- Science and Technology Innovation Program of Hunan Province of China
- China Postdoctoral Science Foundation
- [22120102002]
- [21977126]
- [22207134]
- [2021B1515020102]
- [2021RC5028]
- [2022M713564]
Cancer, a leading cause of death, requires minimally invasive methods to eradicate tumors and prevent recurrence. Photodynamic immunotherapy, utilizing photosensitizers as immunotherapy triggers, shows potential in combining the effects of photodynamic therapy and tumor immunotherapy. However, there is still room for improvement in this newly proposed treatment.
Cancer ranks as a leading cause of death. There is an urgent need to develop minimally invasive methods to eradicate tumors and prevent their recurrence. As a light-driven modality, photodynamic therapy takes advantage of high tumor selectivity and low normal tissue damage. However, it shows poor potential for preventing tumor recurrence. Immunotherapy is currently being used as an alternative treatment for the control of malignant diseases. Although immunotherapy can establish long-time immune memory and efficiently protects treated patients from cancer relapse, its clinical efficacy is limited by the minority of patients' responding rate. Recently, photodynamic immunotherapy, which utilizes photosensitizers as an immunotherapy trigger to exert synergistic effects of photodynamic therapy and tumor immunotherapy, has attracted considerable interest. Like all the newly proposed treatments, there is still room for improvement. In this mini review, the progress in photodynamic immunotherapy with metal-based photosensitizers is summarized. It is hoped that this review can give a broad update on photodynamic immunotherapy and inspire readers.
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