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CANCER DISCOVERY (2019)
CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer
Brooke A. Pereira et al.
TRENDS IN CANCER (2019)
The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts
Tianyi Liu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts
Ju Hun Yeon et al.
ACTA BIOMATERIALIA (2018)
Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling
Yanmei Yi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy
Jun Zhao et al.
BIOMATERIALS (2018)
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
Ana Costa et al.
CANCER CELL (2018)
Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer
Zongyuan Yang et al.
CANCER LETTERS (2018)
Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Dhruv Kumar et al.
CANCER RESEARCH (2018)
LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates
James W. Purcell et al.
CANCER RESEARCH (2018)
Podoplanin: An emerging cancer biomarker and therapeutic target
Harini Krishnan et al.
CANCER SCIENCE (2018)
CD10+ GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
Shicheng Su et al.
CELL (2018)
Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
Julius Strauss et al.
CLINICAL CANCER RESEARCH (2018)
Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1
Xiaoxun Wang et al.
EXPERIMENTAL CELL RESEARCH (2018)
Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells
Aws Abdul-Wahid et al.
INTERNATIONAL JOURNAL OF CANCER (2018)
Fibroblast heterogeneity: implications for human disease
Magnus D. Lynch et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial
Sonia Pernas et al.
LANCET ONCOLOGY (2018)
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
Pernilla Roswall et al.
NATURE MEDICINE (2018)
Targeting the PI3K pathway in cancer: are we making headway?
Filip Janku et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Daniel E. Johnson et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features
Sharathchandra Arandkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Cancer-associated fibroblasts induce PDL1+neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
Yusheng Cheng et al.
CELL DEATH & DISEASE (2018)
Primed atypical ductal hyperplasia-associated fibroblasts promote cell growth and polarity changes of transformed epithelium-like breast cancer MCF-7 cells via miR-200b/c-IKKβ signaling
Yan Sun et al.
CELL DEATH & DISEASE (2018)
Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
Tian Fang et al.
NATURE COMMUNICATIONS (2018)
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Aurelie S. Cazet et al.
NATURE COMMUNICATIONS (2018)
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
Jing Ren et al.
THERANOSTICS (2018)
Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance
Ziqian Li et al.
CANCER RESEARCH AND TREATMENT (2018)
Exosomes Released by Gastric Cancer Cells Induce Transition of Pericytes Into Cancer-Associated Fibroblasts
Xiaofei Ning et al.
MEDICAL SCIENCE MONITOR (2018)
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export
Nil Ege et al.
CELL SYSTEMS (2018)
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
Maria Apicella et al.
CELL METABOLISM (2018)
HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis
Xusheng Ding et al.
CELL DEATH & DISEASE (2018)
Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism
Sandro Goruppi et al.
CELL REPORTS (2018)
FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors
Viviana Cremasco et al.
CANCER IMMUNOLOGY RESEARCH (2018)
Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
Alberto Herrera et al.
ONCOGENESIS (2018)
Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p
Yao-yin Li et al.
EBIOMEDICINE (2018)
Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer
Davide Melisi et al.
BRITISH JOURNAL OF CANCER (2018)
Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo
Deby F. Mardhian et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts
Yuan Zhou et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Melanoma cell-secreted exosomal miR-1555p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway
Xiaocheng Zhou et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
Ankur Chakravarthy et al.
NATURE COMMUNICATIONS (2018)
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Up-regulation of CXCL12
Bharti Garg et al.
GASTROENTEROLOGY (2018)
LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem-like Cells
Chungang Liu et al.
CANCER RESEARCH (2018)
Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression
Patricia Dauer et al.
CANCER RESEARCH (2018)
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
Heather M. Brechbuhl et al.
CLINICAL CANCER RESEARCH (2017)
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
Zhaohui Yang et al.
DISEASE MODELS & MECHANISMS (2017)
Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets
Yufang Shi et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
Y. Deng et al.
ONCOGENE (2017)
Non-Smad Signaling Pathways of the TGF-β Family
Ying E. Zhang
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin
Begum Erdogan et al.
JOURNAL OF CELL BIOLOGY (2017)
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
Fotios Mpekris et al.
JOURNAL OF CONTROLLED RELEASE (2017)
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Daniel Ohlund et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury
Yingying Hu et al.
NEUROSCIENCE LETTERS (2017)
Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression
N. Kramer et al.
ONCOGENE (2017)
CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma
Hongfang Zhang et al.
CELL DEATH & DISEASE (2017)
Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer
Simona Camorani et al.
THERANOSTICS (2017)
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Sandro Goruppi et al.
CELL REPORTS (2017)
FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells
Lukasz Turczyk et al.
NEOPLASIA (2017)
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
Maya Saison-Ridinger et al.
PLOS ONE (2017)
c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice
Takeshi Sato et al.
CANCER SCIENCE (2017)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Lucia Borriello et al.
CANCER RESEARCH (2017)
Putting p53 in Context
Edward R. Kastenhuber et al.
CELL (2017)
SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression
Eunae You et al.
CANCER RESEARCH (2017)
The non-canonical NF-κB pathway in immunity and inflammation
Shao-Cong Sun
NATURE REVIEWS IMMUNOLOGY (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis
Zhuochao Zhang et al.
CANCER LETTERS (2017)
Fibroblast-led cancer cell invasion is activated by epithelial mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma
Shinya Neri et al.
CANCER LETTERS (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles
Pasquale Sansone et al.
CANCER RESEARCH (2017)
Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors
Giovanni Valenti et al.
CANCER RESEARCH (2017)
Mechanisms and consequences of Jak-STAT signaling in the immune system
Alejandro V. Villarino et al.
NATURE IMMUNOLOGY (2017)
Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients
M. A. Frassanito et al.
LEUKEMIA (2016)
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
Genichiro Ishii et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma
Jine Yang et al.
CANCER LETTERS (2016)
GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo
Zhang Zhang et al.
CANCER LETTERS (2016)
p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth
Yoshito Hayashi et al.
CARCINOGENESIS (2016)
Negative control of CSL gene transcription by stress/DNA damage response and p53
Elena Menietti et al.
CELL CYCLE (2016)
p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis
Anna Brichkina et al.
GENES & DEVELOPMENT (2016)
Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia
Xin Liu et al.
GENES & DEVELOPMENT (2016)
Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts
Kun Zhang et al.
JOURNAL OF CELL SCIENCE (2016)
Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer
Yang Chong et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)
Melanoma miRNA trafficking controls tumour primary niche formation
Shani Dror et al.
NATURE CELL BIOLOGY (2016)
Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI)
I. Garcia-Palmero et al.
ONCOGENE (2016)
A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma
Andrew H. Ko et al.
PANCREAS (2016)
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
Ainhoa Arina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Pericyte-fibroblast transition promotes tumor growth and metastasis
Kayoko Hosaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-1
Pedro Barcellos-de-Souza et al.
STEM CELLS (2016)
HSF1 Guardian of Proteostasis in Cancer
Chengkai Dai et al.
TRENDS IN CELL BIOLOGY (2016)
Transcriptional Control by the SMADs
Caroline S. Hill
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Signaling Receptors for TGF-β Family Members
Carl-Henrik Heldin et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Marco Gerling et al.
NATURE COMMUNICATIONS (2016)
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Alexandra Avgustinova et al.
NATURE COMMUNICATIONS (2016)
Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation
J-t Cheng et al.
ONCOGENESIS (2016)
The biology and function of fibroblasts in cancer
Raghu Kalluri
NATURE REVIEWS CANCER (2016)
Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway
Xiao-Ping Zhao et al.
CANCER LETTERS (2015)
Akt-Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression
Yumiko Yamamura et al.
CANCER RESEARCH (2015)
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
Fa-Xing Yu et al.
CELL (2015)
Mesenchymal Cell Contributions to the Stem Cell Niche
Youmna Kfoury et al.
CELL STEM CELL (2015)
Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma
Shinya Neri et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
Yuefeng Du et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2015)
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
Daniel V. T. Catenacci et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
Charles K. Pallangyo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer et al.
NATURE (2015)
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Maria-Giuseppina Procopio et al.
NATURE CELL BIOLOGY (2015)
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity
Carolina S. Ilkow et al.
NATURE MEDICINE (2015)
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Naoko Takebe et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
Jean Albrengues et al.
NATURE COMMUNICATIONS (2015)
Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
Daoxiang Zhang et al.
CELL REPORTS (2015)
Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts
Keun-Woo Lee et al.
CANCER RESEARCH (2015)
Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Jelena Stanisavljevic et al.
CANCER RESEARCH (2015)
p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion
Bangxing Hong et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer
C. E. Weber et al.
ONCOGENE (2015)
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
Berna C. Oezdemir et al.
CANCER CELL (2014)
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Andrew D. Rhim et al.
CANCER CELL (2014)
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Ruth Scherz-Shouval et al.
CELL (2014)
Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling
Susann Weissmueller et al.
CELL (2014)
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signaling
Tsuyoshi Hasegawa et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Arecoline- induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1
Yu-Chao Chang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)
Fibroblast heterogeneity in the cancer wound
Daniel Oehlund et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
Nataliya Razumilava et al.
JOURNAL OF HEPATOLOGY (2014)
Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts
Tat-San Lau et al.
JOURNAL OF PATHOLOGY (2014)
Can we safely target the WNT pathway?
Michael Kahn
NATURE REVIEWS DRUG DISCOVERY (2014)
FGF Receptors: Cancer Biology and Therapeutics
Masaru Katoh et al.
MEDICINAL RESEARCH REVIEWS (2014)
Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts
L. J. A. C. Hawinkels et al.
ONCOGENE (2014)
TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion
Ryo Otomo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The role of reactive oxygen species and metabolism on cancer cells and their microenvironment
Ana Costa et al.
SEMINARS IN CANCER BIOLOGY (2014)
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach et al.
CANCER DISCOVERY (2014)
Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling
Esha Mathew et al.
CELL REPORTS (2014)
Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-α and Heme Oxygenase-1
James N. Arnold et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Non-canonical Notch signaling in cancer and immunity
Furkan Ayaz et al.
FRONTIERS IN ONCOLOGY (2014)
Fibroblast-Specific Protein 1/S100A4-Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens
Jinhua Zhang et al.
CANCER RESEARCH (2013)
TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment
Tsz-Lun Yeung et al.
CANCER RESEARCH (2013)
Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
Thomas A. Mace et al.
CANCER RESEARCH (2013)
Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Ludivine Bochet et al.
CANCER RESEARCH (2013)
Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
Alfonso Quintas-Cardama et al.
CLINICAL CANCER RESEARCH (2013)
Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene-Obong et al.
GASTROENTEROLOGY (2013)
Platelet-Derived Growth Factor-D and Rho GTPases Regulate Recruitment of Cancer-Associated Fibroblasts in Cholangiocarcinoma
Massimiliano Cadamuro et al.
HEPATOLOGY (2013)
Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
Kei Shinagawa et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Hepatic stellate cells in liver development, regeneration, and cancer
Chunyue Yin et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
Peter J. Ratcliffe
JOURNAL OF PHYSIOLOGY-LONDON (2013)
Influence of tumour micro-environment heterogeneity on therapeutic response
Melissa R. Junttila et al.
NATURE (2013)
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
Fernando Calvo et al.
NATURE CELL BIOLOGY (2013)
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Dereck Amakye et al.
NATURE MEDICINE (2013)
Origin and function of myofibroblasts in kidney fibrosis
Valerie S. LeBleu et al.
NATURE MEDICINE (2013)
Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility
O. Aprelikova et al.
ONCOGENE (2013)
Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
Christine Feig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives
Maria Vittoria Dieci et al.
CANCER DISCOVERY (2013)
Tracking cells in their native habitat: lineage tracing in epithelial neoplasia
Maria P. Alcolea et al.
NATURE REVIEWS CANCER (2013)
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Douglas Hanahan et al.
CANCER CELL (2012)
EMT and Dissemination Precede Pancreatic Tumor Formation
Andrew D. Rhim et al.
CELL (2012)
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
Qian Qin et al.
CELL RESEARCH (2012)
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
John J. O'Shea et al.
IMMUNITY (2012)
HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts
Song Yi Ko et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer
Rosa F. Hwang et al.
MOLECULAR CANCER RESEARCH (2012)
Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature
Yuval Rinkevich et al.
NATURE CELL BIOLOGY (2012)
MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE
John M. Kyriakis et al.
PHYSIOLOGICAL REVIEWS (2012)
The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway
Wanjin Hong et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Inhibition of TGF-β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts and Abolishes Their Protumor Effects
Lei Shangguan et al.
STEM CELLS (2012)
Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease
Julius Anckar et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
Michael Quante et al.
CANCER CELL (2011)
Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
Jacky G. Goetz et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Vimentin in cancer and its potential as a molecular target for cancer therapy
Arun Satelli et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
Hedgehog Activates Fused through Phosphorylation to Elicit a Full Spectrum of Pathway Responses
Qianhe Zhou et al.
DEVELOPMENTAL CELL (2011)
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
K. Vuoriluoto et al.
ONCOGENE (2011)
Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer
M. Musumeci et al.
ONCOGENE (2011)
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
Christoph H. Oesterreicher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
Joyce T. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors
Constantin Jotzu et al.
CELLULAR ONCOLOGY (2011)
Notch signalling in solid tumours: a little bit of everything but not all the time
Prathibha Ranganathan et al.
NATURE REVIEWS CANCER (2011)
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
Neta Erez et al.
CANCER CELL (2010)
Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts
Kimberly Walter et al.
CLINICAL CANCER RESEARCH (2010)
Interactions between Hedgehog proteins and their binding partners come into view
Philip A. Beachy et al.
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