期刊
CELL METABOLISM
卷 22, 期 2, 页码 219-227出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.06.022
关键词
-
资金
- National Institutes of Health [P50-GM60338, R01-GM05668, T32 GM008256, H133P110012]
- Clinical and Translational Science Award [UL1TR000071]
- Shriners Hospitals for Children [85310, 85300, 85130, 84090, 84080, 84060, 71001, 71008, 79141, 71006]
- John Sealy Memorial Endowment Fund for Biomedical Research [66992]
- ADA [1-14-TS-35]
- National Institute of Disability and Rehabilitation Research Training Grant [H133P110012]
- Onassis Foundation
Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density, and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据