P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia

Background: Sensory gating deficits and gray matter volume (GMV) abnormalities have been found to be asso-ciated with the pathogenesis and psychopathology of patients with schizophrenia (SCZ). However, no studies have investigated their interrelationship in first-episode treatment-naive (FETN) SCZ patients.Methods: We recruited 52 FETN SCZ patients and 57 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to measure the psychopathology of the patients. We collected magnetic resonance imaging and P50 inhibition data from all participants. Results: Compared to healthy controls, patients had shorter S1 and S2 latencies but larger S2 amplitudes and P50 ratio (Bonferroni adjusted all p < 0.01). In patients, S2 latency was independently associated with PANSS total score, negative symptoms and general psychopathology (t = 2.26-2.58, both P < 0.05), whereas S1 (t = 2.44, P < 0.05) and S2 latencies (t = 2.13, P < 0.05) were associated with PANSS cognitive factor. Moreover, GMV in the left inferior temporal gyrus, left lingual gyrus and right superior occipital gyrus, and bilateral dorsolateral su-perior frontal gyrus were each associated with the P50 components (all p < 0.05). In addition, GMV associated with S2 latency was negatively correlated with PANSS general psychopathology (t =-2.46, p < 0.05) and total score (t =-2.34, p < 0.05). Conclusions: Our findings indicate that FETN SCZ patients exhibit deficits in P50 inhibition and GMV of brain regions associated with these deficits may be associated with their psychopathological symptoms, suggesting that brain structures associated with P50 components may be important biomarkers of SCZ psychopathology. Future studies could use a prospective longitudinal design to investigate the potential causal relationship of brain structures associated with P50 components in the psychopathological symptoms of SCZ patients.

Automated summary

This study found that first-episode, treatment-naive schizophrenia patients have deficits in sensory gating and gray matter volume abnormalities. The latency of S2 is associated with positive and negative symptoms, as well as general psychopathology, while the latencies of S1 and S2 are associated with cognitive factors. Moreover, gray matter volumes in specific brain regions associated with P50 components are negatively correlated with psychopathological symptoms.