期刊
CELL METABOLISM
卷 22, 期 1, 页码 31-53出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.05.023
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资金
- Heart and Stroke Foundation of Canada
- Ecole Polytechnique Federale de Lausanne
- National Institutes of Health [R01AG043930]
- Swiss National Science Foundation [31003A-124713]
- Systems X [51RTP0-151019]
- Swiss National Science Foundation (SNF) [31003A_124713] Funding Source: Swiss National Science Foundation (SNF)
NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
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