期刊
CELL METABOLISM
卷 22, 期 5, 页码 761-776出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.08.016
关键词
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资金
- Leon Levy Foundation
- BrightFocus Foundation
- [NS37853]
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative disease beginning decades prior to the cognitive decline. While cognitive deficits remain the cardinal manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in body weight and neuroendocrine functions, are also present, often preceding the cognitive decline. Furthermore, hypothalamic dysfunction can also be a driver of AD pathology. Here we offer a brief appraisal of hypothalamic dysfunction in AD and provide insight into an underappreciated dual role of the hypothalamus as both a culprit and target of AD pathology, as well as into new opportunities for therapeutic interventions and biomarker development.
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