期刊
FRONTIERS IN PUBLIC HEALTH
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpubh.2022.1029962
关键词
chronic kidney disease; cataract; risk factors; epidemiology; longitudinal cohort; cross-sectional cohort; glomerular filtration rate
资金
- Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Kaohsiung Medical University Research Center Grant [KMU-TC111A01-1, KMUTC111IFSP01]
The study found a significant association between CKD and the probability of developing cataracts, with a higher incidence of cataracts in the CKD group in the validation cohort. Therefore, CKD patients and their primary physicians should be aware of the possible relationship between CKD and cataracts.
IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts. MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline. Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments.
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