期刊
DIAGNOSTICS
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics13010021
关键词
flow cytometry; immunophenotype; measurable residual disease; acute lymphoblastic leukemia
Measurable residual disease (MRD) is an independent prognostic factor in acute leukemias. Multicolor flow cytometry (MFC) is used to detect MRD and determine the antigen expression profile of residual blast cells. The MRD immunophenotype is associated with relapse-free survival (RFS) and can be an additional prognostic factor for B-cell acute lymphoblastic leukemia (B-ALL) patients.
Measurable residual disease (MRD) is a well-known independent prognostic factor in acute leukemias, and multicolor flow cytometry (MFC) is widely used to detect MRD. MFC is able not only to enumerate MRD accurately but also to describe an antigen expression profile of residual blast cells. However, the relationship between MRD immunophenotype and patient survival probability has not yet been studied. We determined the prognostic impact of MRD immunophenotype in adults with B-cell acute lymphoblastic leukemia (B-ALL). In a multicenter study RALL-2016 (NCT03462095), 267 patients were enrolled from 2016 to 2022. MRD was assessed at the end of induction (day 70) in 94 patients with B-ALL by six- or 10-color flow cytometry in the bone marrow specimens. The 4 year relapse-free survival (RFS) was lower in MRD-positive B-ALL patients [37% vs. 78% (p < 0.0001)]. The absence of CD10, positive expression of CD38, and high expression of CD58 on MRD cells worsened the 4 year RFS [19% vs. 51% (p = 0.004), 0% vs. 51% (p < 0.0001), and 21% vs. 40% (p = 0.02), respectively]. The MRD immunophenotype is associated with RFS and could be an additional prognostic factor for B-ALL patients.
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