Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients

Background: Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 expression with various clinical and laboratory findings in 62 newly diagnosed acute lymphoblastic leukemia patients. Methods: All patients were subjected to full history taking, a thorough clinical examination, and laboratory investigations, which included complete blood count (CBC), BM aspiration, immunophenotyping of blast cells, and CD200 expression. Results: There is a higher statistically significant mean value of CD200 expression among the cases (66.15 +/- 23.08) than the control group (0.37 +/- 0.2) (p value <= 0.001). CD200 expression shows a significant correlation with total leucocytic count and hemoglobin level (p = 0.001, 0.03, respectively). Conclusions: This study showed that CD200 expression was expressed in 100% of the patients. Correlations between CD200 expression and different laboratory data of patients revealed that there was an impact of CD200 on different diagnostic findings. After the follow-up of the patients, we found that the use of PRISM function of the software could add value to the detection of minimal residual disease.

Automated summary

This study aimed to investigate the expression pattern of CD200 in acute lymphoblastic leukemia patients and its correlation with clinical and laboratory findings. The results showed a significantly higher expression of CD200 in patients compared to the control group. CD200 expression was found to be significantly correlated with total leukocytic count and hemoglobin level.