4.6 Review

Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis

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Summary: This study evaluated and compared the diagnostic yields of fine-needle aspiration (FNA) and fine-needle biopsy (FNB) using conventional FNA and Franseen needles in patients with solid pancreatic mass. The results showed that FNB using the Franseen needle had a higher diagnostic yield, fewer needle passes, and shorter total procedure time compared to FNA using the conventional FNA needle, without serious adverse events.

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Summary: The meta-analyses showed that fine-needle biopsy (FNB) outperformed fine-needle aspiration (FNA) in obtaining tissue samples, with higher diagnostic accuracy and tissue core rate, and requiring fewer passes for diagnosis. Among different FNB devices, forward-facing bevel needles demonstrated higher diagnostic accuracy compared to reverse bevel needles. However, due to low quality of evidence, further research is needed to make strong recommendations on the optimal FNB design.

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Endoscopic Ultrasound-Guided Fine Needle Biopsy Needles Provide Higher Diagnostic Yield Compared to Endoscopic Ultrasound-Guided Fine Needle Aspiration Needles When Sampling Solid Pancreatic Lesions: A Meta-Analysis

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Summary: This meta-analysis found that compared to FNB, FNA showed differences in diagnostic accuracy, cytopathologic accuracy, and number of passes required for solid pancreatic lesions, but there was no significant difference in safety between the two techniques. Therefore, FNB should be prioritized by endosonographers when evaluating solid pancreatic masses.

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