4.6 Article

Essential Oils Extracted from Boswellia sacra Oleo Gum Resin Loaded into PLGA-PCL Nanoparticles: Enhanced Cytotoxic and Apoptotic Effects against Breast Cancer Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Molecular evidences on anti-inflammatory, anticancer, and memory-boosting effects of frankincense

Mina Khajehdehi et al.

Summary: Chemical diversity in natural products attracts attention in medicine for developing safe and effective drugs. Frankincense, with its main component boswellic acid, has anti-inflammatory effects and is traditionally used to treat memory-related diseases. Consumption of Frankincense improves memory, prevents inflammation and cancer through molecular pathways.

PHYTOTHERAPY RESEARCH (2022)

Article Pharmacology & Pharmacy

PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

Sherif Ashraf Fahmy et al.

Summary: This study aimed to design a pH-responsive dual-loaded nanosystem for the effective treatment of breast cancer. The nanosystem was based on PEGylated chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX). The prepared nanoparticles showed high entrapment efficiencies and spherical-shaped morphology. PEGylation of the nanoparticles reduced their surface charges and enabled drug release in the acidic environment of cancer tissue. The PEGylated nanoparticles exhibited significant cytotoxic activities against breast adenocarcinoma cells and enhanced the apoptotic effect of AA and OX alone or in combination.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

PLGA/PEG Nanoparticles Loaded with Cyclodextrin-Peganum harmala Alkaloid Complex and Ascorbic Acid with Promising Antimicrobial Activities

Sherif Ashraf Fahmy et al.

Summary: This study successfully improved the water solubility and bioavailability of harmala alkaloids using a complex and nanoparticle approach, and demonstrated high antibacterial and antiviral activity.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Enhanced Anticancer Activity of Nedaplatin Loaded onto Copper Nanoparticles Synthesized Using Red Algae

Nada Mostafa Aboeita et al.

Summary: This study optimized the ultrasound-assisted extraction technique to extract a highly antioxidant extract from red algae. The extract was then used for the synthesis of copper nanoparticles, which were loaded with nedaplatin to enhance its anticancer effect.

PHARMACEUTICS (2022)

Article Biochemistry & Molecular Biology

Ozonated Olive Oil: Enhanced Cutaneous Delivery via Niosomal Nanovesicles for Melanoma Treatment

Sherif Ashraf Fahmy et al.

Summary: This study designed and optimized a niosomal vesicular nanoplatform loaded with ozonated olive oil (OL) to improve its solubility, skin permeation, and anticancer activity. The encapsulated OL showed enhanced water solubility, skin permeation, and double the anticancer activity compared to free OL.

ANTIOXIDANTS (2022)

Article Engineering, Biomedical

Dynamic ginsenoside-sheltered nanocatalysts for safe ferroptosis-apoptosis combined therapy

Xiaoxiong Zhao et al.

Summary: This study demonstrates that surface engineering of ginsenoside Rg3 dramatically alters the distribution and enrichment of nanocatalysts in tumor, leading to improved efficacy and reduced toxicity. The Rg3-sheltered dynamic nanocatalysts can activate ferroptosis and apoptosis simultaneously, resulting in significant anticancer effects.

ACTA BIOMATERIALIA (2022)

Article Biochemistry & Molecular Biology

α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Hantae Jo et al.

Summary: The study focused on the role of phytoncides in activating NK cells and enhancing anticancer effects. Results showed that alpha-pinene treatment increased NK cell cytotoxicity and inhibited tumor growth, suggesting its potential in cancer immunotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Applied

Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure

Eda Becer et al.

Summary: This study found that Boswellia sacra essential oil exhibited anti-cancer activity in CD133+ and CD133- Colo-320 cells by reducing beta-catenin signaling molecules that are crucial for cancer cell proliferation, and promoting apoptosis in CD133- Colo-320 cells.

JOURNAL OF ESSENTIAL OIL RESEARCH (2021)

Review Chemistry, Medicinal

Anticancer activity of limonene: A systematic review of target signaling pathways

Heitor Gomes de Araujo-Filho et al.

Summary: Limonene (LIM), a monoterpene abundant in Citrus fruits peels, has shown potential as a natural anticancer compound by inhibiting tumor initiation, growth, and angiogenesis, as well as inducing cancer cells apoptosis.

PHYTOTHERAPY RESEARCH (2021)

Article Chemistry, Multidisciplinary

Peganum harmala Alkaloids Self-Assembled Supramolecular Nanocapsules with Enhanced Antioxidant and Cytotoxic Activities

Sherif Ashraf Fahmy et al.

Summary: Amphiphilic macrocycles like p-sulfonatocalix[6]arenes have shown potential in designing synthetic nanovesicles. These nanovesicles can improve drug solubility, stability, and biological activity. Encapsulation of harmala alkaloid-rich fraction (HARF) in p-SC6 nanocapsules significantly increased antioxidant and cytotoxic activities.

ACS OMEGA (2021)

Article Polymer Science

Cefotaxime Loaded Polycaprolactone Based Polymeric Nanoparticles with Antifouling Properties for In-Vitro Drug Release Applications

Sana Javaid et al.

Summary: This study successfully achieved the encapsulation of a therapeutic agent for antifouling functionality using nanotechnology. The drug-loaded nanoparticles showed potential for in vitro drug release and antifouling applications after optimization.

POLYMERS (2021)

Article Chemistry, Multidisciplinary

Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities

Hassan Mohamed El-Said Azzazy et al.

Summary: This study developed a formulation with potential antibacterial wound healing properties by loading harmala alkaloid-rich fraction into poly (lactic-co-glycolic acid) nanoparticles coated with chitosan. The optimized nanoparticles exhibited high antibacterial activity against Staphylococcus aureus and Escherichia coli, as well as biocompatibility with human skin fibroblasts. The designed nanoformulation showed synergistic antibacterial and wound healing properties for the management of infected wounds.

NANOMATERIALS (2021)

Review Pharmacology & Pharmacy

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Sherif Ashraf Fahmy et al.

Summary: Photodynamic therapy is a promising cancer treatment strategy that utilizes highly reactive oxygen species to kill cancer cells. However, it has shortcomings, leading researchers to develop various nanoplatforms to enhance treatment effectiveness.

PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Betaine host-guest complexation with a calixarene receptor: enhanced in vitro anticancer effect

Sherif Ashraf Fahmy et al.

Summary: p-Sulfonatocalix[n]arenes can form host-guest complexes with chemotherapeutic drugs, enhancing their anticancer activity; the host-guest complex of betaine with p-SC4 in an acidic environment shows potential for cancer therapy by increasing betaine concentration in cancer cells.

RSC ADVANCES (2021)

Article Multidisciplinary Sciences

Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

Miljan Milosevic et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Multidisciplinary

Experimental and Computational Investigations of Carboplatin Supramolecular Complexes

Sherif Ashraf Fahmy et al.

ACS OMEGA (2020)

Article Chemistry, Medicinal

The Chemical Composition of Boswellia occulta Oleogum Resin Essential Oils

Stephen Johnson et al.

NATURAL PRODUCT COMMUNICATIONS (2019)

Article Polymer Science

Effect of natamycin on the physicochemical properties of corn starch based films and their effect on Penicillium spp. activity

Lucia del Sol Gonzalez-Forte et al.

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION (2019)

Proceedings Paper Nanoscience & Nanotechnology

A study on the physicochemical properties and cytotoxic activity of p-sulfocalix[4]arene-nedaplatin complex

Sherif Ashraf Fahmy et al.

APPLIED NANOTECHNOLOGY AND NANOSCIENCE INTERNATIONAL CONFERENCE (ANNIC 2018) (2019)

Article Polymer Science

Garlic oil-loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Sherif Ashraf Fahmy et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2018)

Article Medicine, Research & Experimental

Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability

Mohammad M. Badran et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Engineering, Biomedical

pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium

Shalil Khanal et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2016)

Article Integrative & Complementary Medicine

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells

Mahmoud M. Suhail et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

Review Pharmacology & Pharmacy

PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

MaLing Gou et al.

CURRENT DRUG TARGETS (2011)

Article Integrative & Complementary Medicine

Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity

Mark Barton Frank et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2009)

Article Pharmacology & Pharmacy

Characterization of drug-chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry

Yaowalak Boonsongrit et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)