期刊
CELL METABOLISM
卷 22, 期 4, 页码 560-575出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.07.010
关键词
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资金
- FQRS fellowship
- Alcon Research Institute Young Investigator Award
- Canadian Institutes of Health Research [324573, 221478]
- Canadian Diabetes Association [OG-3-11-3329-PS]
- Foundation Fighting Blindness Canada (FFB)
- Natural Sciences and Engineering Research Council of Canada [418637]
- Fondation HMR
- Reseau en Recherche en Sante de la Vision du Quebec
- Fond en Recherche en Opthalmologie de l'UdM
Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth. In this regard, the classical pathways of the unfolded protein response activated under conditions of ER stress have recently been described to generate angiomodulatory or angiostatic signals. This review elaborates on the link between angiogenesis and ER stress and discusses the implications for diseases characterized by altered vascular homeostasis, such as cancer, retinopathies, and atherosclerosis.
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