Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.

Automated summary

Zerumbone is a multifunctional compound with various applications, including antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory properties. It is found in high content in wild ginger and can be used as a distinctive feature for identification and differentiation. However, further research is needed to improve its solubility, bioavailability, and preservation, as well as demonstrate its in vivo efficacy through preclinical and clinical studies.