期刊
BRAIN SCIENCES
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/brainsci12111519
关键词
multiple sclerosis; video head impulse test; vestibulo-ocular reflex; compensatory saccade
资金
- National Multiple Sclerosis Society
- Department of Defense, Congressionally Directed Medical Research Programs [NMSS RG-1701-26763]
- Department of Defense under the Neurosensory and Rehabilitation Research Award Program [W8lXWH-l7-CTRR-CTA]
- Foundation for Physical Therapy Research New Investigator Fellowship Training Initiative (NIFTI) [W81XWH-15-1-0442]
- Foundation for Physical Therapy Research
This study found that the vestibular function and compensatory oculomotor behaviors in multiple sclerosis (MS) patients may vary depending on the level of disability. Worse disability was associated with poorer vestibular function and compensatory oculomotor function.
Globally, there are nearly three million people living with multiple sclerosis (PLW-MS). Many PLW-MS experience vertigo and have signs of vestibular dysfunction, e.g., low vestibulo-ocular reflex (VOR) gains or the presence of compensatory saccades (CSs), on video head impulse testing (vHIT). We examined whether the vestibular function and compensatory oculomotor behaviors in PLW-MS differed based on the level of MS-related disability. The VOR gain, CS frequency and latency, and gaze position error (GPE) were calculated from the individual traces obtained during six-canal vHIT for 37 PLW-MS (mean age 53.4 +/- 12.4 years-old, 28 females) with vertigo and/or an imbalance. The subjects were grouped by their Expanded Disability Status Scale (EDSS) scores: PLW-min-MS (EDSS = 1.0-2.5, n = 8), PLW-mild-MS (EDSS = 3.0-4.5, n = 23), and PLW-moderate-MS (EDSS = 5.0-6.0, n = 6). The between-group differences were assessed with Kruskal-Wallis tests. The VOR gains for most of the canals were higher for PLW-min-MS compared to PLW-mild- and mod-MS, respectively. CS occurred less often in PLW-min-MS versus PLW-mild- and mod-MS, respectively. No clear trend in CS latency was found. The GPE was often lower for PLW-min-MS compared to PLW-mild- and mod-MS, respectively. Thus, our data demonstrate that worse VOR and compensatory oculomotor functions are associated with a greater MS-related disability. PLW-MS may benefit from personalized vestibular physical therapy.
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