期刊
BRAIN SCIENCES
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/brainsci12111544
关键词
dystrophinopathies; Wechsler Intelligence Scales; meta-analysis
资金
- European Union [847826]
This study conducted a literature review and meta-analysis to investigate the intellectual functioning of males with Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). The findings indicate that DMD patients have significantly lower intelligence scores compared to BMD patients and the general population.
Background: Intelligence scores in males with Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) remain a major issue in clinical practice. We performed a literature review and meta-analysis to further delineate the intellectual functioning of dystrophinopathies. Method: Published, peer-reviewed articles assessing intelligence, using Wechsler Scales, of males with DMD or BMD were searched from 1960 to 2022. Meta-analysis with random-effects models was conducted, assessing weighted, mean effect sizes of full-scale IQ (FSIQ) scores relative to normative data (Mean = 100, Standard Deviation = 15). Post hoc we analysed differences between performance and verbal intelligence scores. Results: 43 studies were included, reporting data on 1472 males with dystrophinopathies; with FSIQ scores available for 1234 DMD (k = 32) and 101 BMD (k = 7). DMD males score, on average, one standard deviation below average (FSIQ = 84.76) and significantly lower than BMD (FSIQ = 92.11). Compared to a previous meta-analysis published in 2001, we find, on average, significantly higher FSIQ scores in DMD. Conclusion: Males with Duchenne have, on average, significantly lower FSIQ scores than BMD males and the general population. Clinicians must consider lower intelligence in dystrophinopathies to ensure good clinical practice.
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