4.5 Article

Impact of Cognitive Impairments on Health-Related Quality of Life in Schizophrenia

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BRAIN SCIENCES
卷 13, 期 2, 页码 -

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MDPI
DOI: 10.3390/brainsci13020215

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cognitive impairments; health-related quality of life; quality of life; schizophrenia; cognitive factor

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The aim of this study was to examine the association between cognitive impairments and health-related quality of life (HRQoL) in individuals with schizophrenia. The study found that cognitive factor g was significantly associated with EQ-5D-5L scores. Age, sex, and employment status were also significant predictors of EQ-5D-5L. These results are important for understanding the burden of cognitive impairments in individuals with schizophrenia.
The impact of cognitive impairments on the health-related quality of life (HRQoL) in individuals with schizophrenia is unclear. The aim of this study was to examine the association between cognitive impairments and HRQoL in individuals with schizophrenia. A total of 609 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and a neurocognitive battery which comprised of the Wechsler Abbreviated Scale of Intelligence matrix reasoning, the Benton Judgment of Line Orientation Test, Continuous Performance Tests-Identical Pairs, and the Brief Assessment of Cognition in Schizophrenia. A cognitive factor g was derived from the neurocognitive battery. EuroQol five-dimensional (EQ-5D-5L) utility scores were derived from PANSS scores via a previously validated algorithm and used as a measure of HRQoL. Hierarchical multiple regression was conducted to examine the association between cognitive factor g and the EQ-5D-5L. Cognitive factor g (beta = 0.189, t = 4.956, p < 0.001) was found to be significantly associated with EQ-5D-5L scores. Age (beta = -0.258, t = -6.776, p < 0.001), sex (beta = 0.081, t = 2.117, p = 0.035), and being employed (beta = 0.091, t = 2.317, p = 0.021) were also significant predictors of EQ-5D-5L. Our results add to the extant literature on the burden cognitive impairments exact in individuals with schizophrenia. More research is needed to develop effective interventions for cognitive impairments in schizophrenia.

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