期刊
CELL METABOLISM
卷 22, 期 1, 页码 100-112出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.06.001
关键词
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资金
- 7th European Framework Program (Flori-nash)
- Agence Nationale de la Recherche (ANR)
- Societe Francophone de Diabetologie (SFD)
- European Association for the Study of Diabetes
A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic phenotype was mimicked in RORgt-deficient mice, which lack IL17 and IL22 function, and in the adoptive transfer experiment of T cells from RORgt-deficient mice into Rag1-deficient mice. We conclude that the microbiota of the ileum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease.
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