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Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery

ANTIBIOTICS-BASEL (2023)

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Lizbeth Hedstrom

CHEMICAL REVIEWS (2009)

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Article Biochemistry & Molecular Biology

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

Katy L. Blake et al.

MOLECULAR MICROBIOLOGY (2009)

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Review Biotechnology & Applied Microbiology

From carbohydrate leads to glycomimetic drugs

Beat Ernst et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

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Article Biochemistry & Molecular Biology

SSB as an Organizer/Mobilizer of Genome Maintenance Complexes

Robert D. Shereda et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)

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Review Microbiology

Membrane lipid homeostasis in bacteria

Yong-Mei Zhang et al.

NATURE REVIEWS MICROBIOLOGY (2008)

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Article Chemistry, Medicinal

Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery

Qingning Shu et al.

MEDICINAL RESEARCH REVIEWS (2008)

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Article Multidisciplinary Sciences

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Fernando L. Rock et al.

SCIENCE (2007)

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Review Biochemistry & Molecular Biology

Evolution of carbohydrate antigens - microbial forces shaping host glycomes?

Joseph R. Bishop et al.

GLYCOBIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis

Shu-Xing Li et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

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Review Chemistry, Medicinal

An integrated approach to fragment-based lead generation: Philosophy, strategy and case studies from AstraZeneca's drug discovery programmes

Jeffrey S. Albert et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase

Nathaniel D. Ginder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Medicine, General & Internal

Mechanisms of antimicrobial resistance in bacteria

Fred C. Tenover

AMERICAN JOURNAL OF MEDICINE (2006)

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Article Chemistry, Medicinal

ZINC - A free database of commercially available compounds for virtual screening

JJ Irwin et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

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Article Biochemistry & Molecular Biology

Coenzyme A biosynthesis: Reconstruction of the pathway in archaea and an evolutionary scenario based on comparative genomics

U Genschel

MOLECULAR BIOLOGY AND EVOLUTION (2004)

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Article Biochemistry & Molecular Biology

Induced fit and kinetic mechanism of adenylation catalyzed by Escherichia coli threonyl-tRNA synthetase

ML Bovee et al.

BIOCHEMISTRY (2003)

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Article Chemistry, Medicinal

Inhibitors of phosphopantetheine adenylyltransferase

LH Zhao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Genes required for mycobacterial growth defined by high density mutagenesis

CM Sassetti et al.

MOLECULAR MICROBIOLOGY (2003)

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Review Microbiology

Why are bacteria refractory to antimicrobials?

D Hogan et al.

CURRENT OPINION IN MICROBIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

M Daugherty et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

RA Forsyth et al.

MOLECULAR MICROBIOLOGY (2002)

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Article Chemistry, Medicinal

Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture

F Zouhiri et al.

JOURNAL OF MEDICINAL CHEMISTRY (2000)

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Review Microbiology

Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process

CR Woese et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2000)

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