Characteristics of tet(X4)-Producing Escherichia coli in Chicken and Pig Farms in Hunan Province, China

Article Environmental Sciences

Structural diversity of the ISCR2-mediated rolling-cycle transferable unit carrying tet(X4)

Dejun Liu et al.

Summary: This study analyzed the diversity of ISCR2 and tet(X4) from different sources, and the results showed that ISCR2 plays a critical role in the dissemination of tet(X4) and other resistance genes.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Prevalence, transmission, and molecular epidemiology of tet(X)-positive bacteria among humans, animals, and environmental niches in China: An epidemiological, and genomic-based study

Ning Dong et al.

Summary: This study reports the prevalence and molecular epidemiology of tet(X)-positive bacteria (TPB) from different sources in China. The study found that tet(X) was highly prevalent in freshwater fishes and chickens, while it was not detected in soil and freshwater samples. Isolates from different families exhibited different antimicrobial resistance profiles. Co-existence of tet(X) with other resistance genes was commonly observed, but inter-host transmission of tet(X)-positive Escherichia coli (E. coli) was not observed.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Microbiology

Prevalence and Characteristics of mcr-1-Producing Escherichia coli in Three Kinds of Poultry in Changsha, China

Jufang Hu et al.

Summary: Colistin is an effective last-line drug against difficult to treat and multidrug-resistant Gram-negative bacteria. The emergence of mcr-1, a mobile colistin resistance gene, has increased global attention on colistin resistance. This study investigated the molecular and epidemiological characteristics of MCRPEC strains from poultry farms in China. It found that MCRPEC strains had a broad resistance spectrum and the ability to transmit resistance to other bacteria.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Emergence of mobile tigecycline resistance gene tet(X4)-harbouring Shewanella xiamenensis in a water environment

Trung Duc Dao et al.

Journal of Global Antimicrobial Resistance (2022)

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Article Infectious Diseases

Clonal relationship of tet(X4)-positive Escherichia coli ST761 isolates between animals and humans

Weishuai Zhai et al.

Summary: This study investigated the relationship of tet(X4)-positive isolates from different hosts and environments. The results showed that these isolates exhibited multidrug resistance, and the majority of them belonged to separate clonal groups. Among these isolates, the E. coli ST761 strains were widely distributed in animals, food, wastewater, and humans. There was a close phylogenetic relationship among these strains, suggesting a potential transmission of tet(X4)-positive E. coli ST761 between humans and animals. Additionally, this study also reported the first description of tet(X4)-positive A. simiae.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Article Microbiology

Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China

Jing Wang et al.

Summary: This study investigated the prevalence and characterization of tet(X4) in Escherichia coli isolates from a pig farm in Shanghai, China, and revealed the dissemination mechanism of tet(X4) in this swine farm. The results showed clonal transmission of tet(X4)-positive E. coli ST761 in this pig farm.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Infectious Diseases

Prevalence and risk factors of tet(X4)-positive Enterobacteriaceae in human gut microbiota

Yu Zeng et al.

Summary: This study aims to investigate the prevalence of tet(X4) in healthy individuals and patients and assess the associated risk factors. The results showed that the prevalence of tet(X4)-positive Enterobacteriaceae in healthy individuals and patients was significantly higher than previous studies in China. Patients aged 19-45 years had a higher odds of tet(X4)-positive bacterial colonization. All tet(X4)-positive Enterobacteriaceae were resistant to tigecycline. Tet(X4)-positive Escherichia coli were highly diverse, with CC10 being the dominant clone. The data from this study suggest that geographic region may partly explain the high prevalence of tet(X4)-positive Enterobacteriaceae in healthy individuals and patients.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

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Article Microbiology

Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China

Jiangang Ma et al.

Summary: Widely distributed multidrug-resistant bacteria pose a threat to animal and human health, but there have been few surveys on the antimicrobial resistance of large-scale animal-derived bacteria. A study in Zhejiang Province, China, found that Escherichia coli strains isolated from pig and chicken anal swab samples showed high resistance to multiple antibiotics, and some strains carried resistance genes against last-resort antimicrobials. Furthermore, a correlation between heavy metals and antibiotic resistance was observed.

MICROBIOLOGY SPECTRUM (2022)

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Article Food Science & Technology

International Spread of Tet(X4)-Producing Escherichia coli Isolates

Zengfeng Zhang et al.

Summary: Tigecycline resistance in bacteria poses a significant threat to food safety and public health, with international spread mainly occurring in Asian countries. Pigs and their products are the most common vehicle for transmission.

FOODS (2022)

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Article Infectious Diseases

Fecal Carriage of Escherichia coli Harboring the tet(X4)-IncX1 Plasmid from a Tertiary Class-A Hospital in Beijing, China

Weishuai Zhai et al.

Summary: The emergence of the mobile tigecycline-resistance gene, tet(X4), poses a significant threat to public health. A study conducted in a hospital in Beijing, China, identified tet(X4)-positive Escherichia coli isolates in human stool samples. These isolates exhibited resistance to multiple antibiotics but remained susceptible to meropenem and polymyxin B. The study revealed the importance of both clonal spread and plasmid-mediated horizontal gene transfer in the spread of tet(X4) within human clinics and between different sources.

ANTIBIOTICS-BASEL (2022)

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Article Engineering, Environmental

Evaluation of culturable 'last-resort' antibiotic resistant pathogens in hospital wastewater and implications on the risks of nosocomial antimicrobial resistance prevalence

Weiwei Li et al.

Summary: This study investigated the extent of resistance to 'last-resort' antibiotics in hospital wastewater. The findings revealed high levels of resistance and prevalent multiple resistance to antibiotics, including 'last-resort' antibiotics. The study also discovered inconsistencies between resistance phenotypes and genotypes, as well as the first occurrence of tet(X4)-containing tigecycline-resistant Gram-positive pathogens. Furthermore, the wastewater treatment processes were effective in preventing the release of 'last -resort' antibiotic resistant pathogens.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Review Microbiology

Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

Shaqiu Zhang et al.

Summary: With the widespread use of antibiotics, antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are considered as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline, is now the last resort for treating multidrug-resistant bacteria. Plasmid-mediated horizontal transfer allows for genetic information sharing among different bacteria. However, the transmission of the tigecycline resistance gene tet(X) may pose a risk to public health and the concept of One Health.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Microbiology

Coproduction of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt

Ahmed M. Soliman et al.

Summary: Plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains isolated from chickens in Egypt, with two fosA4-carrying IncFII plasmids detected. Transposase ISCR3 was found to be syntenic with tet(X7) in all isolates, indicating its role in the mobilization of tet(X7). This study represents the first global report of ST4-IncHI2 plasmids co-carrying tet (X7) and mcr-1.1 from chickens.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Microbiology

Comprehensive Genomic Investigation of Tigecycline Resistance Gene tet(X4)-Bearing Strains Expanding among Different Settings

Ruichao Li et al.

Summary: This study identified 58 strains of bacteria carrying the tet(X4) gene in fresh pork samples from multiple regions in China, with Escherichia coli being the predominant species. Four novel tet(X4)-positive bacterial species were also characterized. Genetic analysis revealed various types of core tet(X4)-bearing genetic environments and tandem duplications. The study highlights the potential transmission risk of animal-borne tet(X4)-bearing pathogens in consumed food, emphasizing the urgent need for large-scale monitoring and effective control measures.

MICROBIOLOGY SPECTRUM (2021)

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Article Microbiology

Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter

Ying-Ying Cheng et al.

Summary: The study identified clonal and sporadic dissemination patterns of plasmid-borne tet(X) genes in Acinetobacter isolates from livestock farms. Plasmid pAT181 was found to be self-transmissible and increased tigecycline resistance and growth rate. The structure of tet(X3) and tet(X6) plasmidomes exhibited high diversity in dissemination.

MICROBIOLOGY SPECTRUM (2021)

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Letter Infectious Diseases