Antimicrobial Treatment of Staphylococcus aureus Biofilms

Staphylococcus aureus is a microorganism frequently associated with implant-related infections, owing to its ability to produce biofilms. These infections are difficult to treat because antimicrobials must cross the biofilm to effectively inhibit bacterial growth. Although some antibiotics can penetrate the biofilm and reduce the bacterial load, it is important to understand that the results of routine sensitivity tests are not always valid for interpreting the activity of different drugs. In this review, a broad discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity in monotherapy and combination therapy is presented that should benefit researchers engaged in optimizing the treatment of infections associated with S. aureus biofilms.

Automated summary

Staphylococcus aureus is frequently associated with implant-related infections due to its ability to produce biofilms, which make these infections difficult to treat. The effectiveness of different drugs in inhibiting bacterial growth within the biofilm cannot always be accurately interpreted using routine sensitivity tests. This review provides a comprehensive discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity, aiming to benefit researchers working on optimizing the treatment of S. aureus biofilm-associated infections.