Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries

Editorial Material Biochemistry & Molecular Biology

Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development

Alessia Catalano

CURRENT MEDICINAL CHEMISTRY (2022)

Article Dentistry, Oral Surgery & Medicine

Global Burden and Inequality of Dental Caries, 1990 to 2019

P. Y. F. Wen et al.

Summary: Dental caries remains a global public health challenge, with lower prevalence in permanent teeth in developed countries and population growth being a key driver of changes in the number of caries cases.

JOURNAL OF DENTAL RESEARCH (2022)

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Review Dentistry, Oral Surgery & Medicine

Strategies for Streptococcus mutans biofilm dispersal through extracellular polymeric substances disruption

Yongwang Lin et al.

Summary: This review summarizes potential strategies to inhibit Streptococcus mutans biofilms through disrupting extracellular polymeric substances (EPS), including signal network intervention and enzyme degradation.

MOLECULAR ORAL MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors

Lubna Atta et al.

Summary: Dental caries, a global oral health concern, can be prevented by inhibiting bacterial biofilm assembly. In this study, small molecule inhibitors of Streptococcus mutans glycosyltransferases were identified through high throughput screening and validated with multiple datasets. These compounds showed excellent antibiofilm activities and have the potential to prevent tooth decay.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Alessia Catalano et al.

Summary: Multidrug resistance, including resistance to anticancer agents and antimicrobial drugs, is a significant concern in public health. The widespread use of antibiotics has led to the emergence of pathogenic bacteria resistant to multiple drugs, and the ongoing COVID-19 pandemic may worsen antimicrobial resistance. Nanodrug delivery systems have shown promise in overcoming resistance.

MOLECULES (2022)

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Article Polymer Science

Facile synthesis of polypeptoids bearing bulky sidechains via urea accelerated ring-opening polymerization of α-amino acid N-substituted N-carboxyanhydrides

Kang Chen et al.

Summary: Polypeptoids as synthetic mimics of polypeptides demonstrate various biological functions and excellent proteolytic stability. The urea-catalyzed NNCA polymerization strategy greatly accelerates the reaction rate and is compatible with diverse NNCAs, especially suitable for inactive NNCAs with bulky N-substitutes.

POLYMER CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Novel urea derivative-loaded PLGA nanoparticles to inhibit caries-associated Streptococcus mutans

Mengyun Zhang et al.

Summary: In this study, a novel urea derivative was encapsulated in PLGA nanoparticles and showed satisfying physicochemical characteristics. The drug-loaded nanoparticles exhibited negligible cytotoxicity against human oral squamous cell carcinoma cells and significantly inhibited the growth and lactic acid production of S. mutans.

RSC ADVANCES (2022)

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Review Immunology

The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases

Sirui Yang et al.

Summary: Oral microbial dysbiosis is a major cause of oral infectious diseases, and researchers have developed antimicrobial small molecules that can inhibit the virulence of oral microbiota and restore microbial ecological balance, showing potential applications in the treatment of oral diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Microbiology

Quorum-Sensing Inhibition by Gram-Positive Bacteria

Evgeniya V. Prazdnova et al.

Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.

MICROORGANISMS (2022)

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Article Dentistry, Oral Surgery & Medicine

Fluoride and calcium release from peppermint-flavored fluoride varnish containing dicalcium-phosphate-dihydrate coated with xylitol

Yosi Kusuma Eriwati et al.

Summary: This study investigated the effect of dicalcium phosphate dihydrate coated with xylitol on the release of fluoride and calcium ions in the oral cavity. The results showed that the addition of xylitol coating improved the bioavailability of the ions. Different concentrations of xylitol had different effects on the release of fluoride and calcium ions.

SAUDI DENTAL JOURNAL (2022)

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Article Chemistry, Physical

Synthesis of diaryl urea derivatives and evaluation of their antiproliferative activities in colon adenocarcinoma

Muhammed Gomec et al.

Summary: Colon cancer is a leading cause of cancer-related deaths. A synthesized compound DAU5 showed cytotoxic effects on HT-29 colon cancer cells and reduced the expression of autophagy and oxidative stress-DNA damage indicators. Further in vivo and clinical studies are required to validate these findings.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Article Chemistry, Multidisciplinary

Asymmetric Azidation under Hydrogen Bonding Phase-Transfer Catalysis: A Combined Experimental and Computational Study

Jimmy Wang et al.

Summary: Asymmetric catalytic azidation using inexpensive sodium azide has been studied using hydrogen bonding phase-transfer catalysis (HB-PTC). The structure of novel hydrogen bonded azide complexes were analyzed computationally, in the solid state by X-ray diffraction, and in solution phase by NMR spectroscopy. This study demonstrates that HB-PTC can be used as an activation mode for inorganic salts other than metal alkali fluorides, showing potential for applications in asymmetric synthesis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Virology

COVID-19 at a Glance: An Up-to-Date Overview on Variants, Drug Design and Therapies

Domenico Iacopetta et al.

Summary: The COVID-19 pandemic caused by the SARS-CoV-2 virus poses a severe threat to public health. The search for vaccines has led to the approval of about twenty COVID-19 vaccines, but new genetic mutations and variants continue to emerge, necessitating pharmacological treatments.Various treatments, including antivirals, antibiotics, immunomodulators, vitamins, and drug repositioning, are being used to combat the spread of the virus.

VIRUSES-BASEL (2022)

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Review Environmental Sciences

In it together: Candida-bacterial oral biofilms and therapeutic strategies

Geelsu Hwang

Summary: Complex polymicrobial biofilms exist in natural and human environments. The interactions between Candida and bacteria are associated with oral diseases. Limited research has been done on treating Candida-bacterial biofilms.

ENVIRONMENTAL MICROBIOLOGY REPORTS (2022)

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Review Dentistry, Oral Surgery & Medicine

Expert consensus on dental caries management

Lei Cheng et al.

Summary: Dental caries is a chronic oral disease that poses a significant threat to human health. Despite efforts by dentists and researchers, the prevalence of dental caries remains high. Establishing a clinical difficulty assessment system for caries prevention and management based on diagnosis and classification is crucial. Dentists should conduct oral examinations and create dental records during each visit. Personalized treatment plans, based on caries risk assessment and lesion activity, are necessary to restore oral microecological balance, control caries progression, and restore the structure and function of the affected teeth. Follow-up visits should be conducted based on personalized caries management. This expert consensus focuses on caries risk assessment, treatment difficulty assessment, and dental caries treatment plans, which are essential components of caries management throughout the life cycle.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

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Article Immunology

Diaryl Urea Derivative Molecule Inhibits Cariogenic Streptococcus mutans by Affecting Exopolysaccharide Synthesis, Stress Response, and Nitrogen Metabolism

Ying Liao et al.

Summary: In this study, the novel diaryl urea derivative BPU was found to inhibit the growth and biofilm formation of cariogenic bacteria Streptococcus mutans. Molecular docking analysis and transcriptomic profile showed that BPU affected key enzymes and biological processes, as well as reduced the synthesis of extracellular exopolysaccharide (EPS). The transcriptomic profile also indicated changes in stress response and nitrogen metabolism in S. mutans treated with BPU. These findings suggest that BPU has the potential to serve as an effective anti-caries agent.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Microbiology

Exploration of the Antimicrobial Synergy between Selected Natural Substances on Streptococcus mutans to Identify Candidates for the Control of Dental Caries

Alisha Prince et al.

Summary: The emergence of bacteria resistant to antimicrobial agents has led to a shortage of options when choosing effective treatment agents. In this study, a synergistic combination of cranberry extracts, manuka honey, and MGO was found, which can be used as an alternative or adjunctive anti-caries therapy.

MICROBIOLOGY SPECTRUM (2022)

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Article Biochemistry & Molecular Biology

Structure-Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism

Edward York et al.

Summary: This paper investigates the mechanism of how the anticancer agent SR4 uncouples mitochondria and develops a library of substituted bisaryl ureas for further studies. The research shows that SR4 uncouples mitochondria through the fatty acid-activated mechanism and identifies a compound that reduces cell viability more effectively than SR4.

ACS CHEMICAL BIOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

Streptococcus mutans and Streptococcus sobrinus contributions in dental caries in Iranian and Afghan children: A report from serotype distribution and novel STs

Masoomeh Elyassi et al.

Summary: This study evaluated the frequency and effects of S. mutans and S. sobrinus on DMFT scores in Iranian and Afghan populations. The study identified the serotypes of S. mutans isolates and performed MLST. The results showed a high frequency of S. mutans and specific serotypes in the samples, indicating the need for further global research. Additionally, novel sequence types of S. mutans were identified.

ARCHIVES OF ORAL BIOLOGY (2022)

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Article Chemistry, Medicinal

Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents

Cheng Wang et al.

Summary: Allergic diseases are unfavorable immune responses caused by allergens, and the MRGPRX2 receptor on mast cells has been found to be associated with IgE-independent immune diseases and allergic reactions. Researchers have designed and synthesized a series of compounds called DPUs, which show promising anti-allergic effects in cell and animal experiments. The study also reveals the molecular mechanism of MRGPRX2 involvement in this process.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Infectious Diseases

Thidiazuron: New Trends and Future Perspectives to Fight Xylella fastidiosa in Olive Trees

Alessia Catalano et al.

Summary: Xylella fastidiosa has re-emerged as a plant pathogen of global importance, affecting olive trees in the Salento region of Italy and leading to an increase in olive oil prices. Urgent research is needed to control its transmission and impact as it is spread by insects.

ANTIBIOTICS-BASEL (2022)

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Review Infectious Diseases

Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation

Paola Hernandez et al.

Summary: Bacteria in the oral cavity coexist with the host under healthy conditions, but dysbiosis can lead to the dominance of opportunistic pathogens. Current preventive measures focus on partially removing plaque, but this can have negative effects on homeostasis and oral ecosystem. Therefore, it is important to maintain balance in the oral microbiota and apply strategies to combat caries.

ANTIBIOTICS-BASEL (2022)

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Article Chemistry, Medicinal

Synthesis and biological evaluation of novel N, N′-diarylurea derivatives as potent antibacterial agents against MRSA

Xiaonan Du et al.

Summary: A series of new N, N'-diarylurea derivatives were designed and synthesized, which showed potent antibacterial activity against drug-resistant Gram-positive strains. Particularly, compounds 2c, 2g-2l exhibited broader antibacterial spectrum and stronger antibacterial activity against MRSA, MRSE, and VRE compared to the control drugs. These compounds also demonstrated low cytotoxicity, indicating a wide therapeutic window and potential for further research.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

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Review Dentistry, Oral Surgery & Medicine

Salivary Proteins as Dental Caries Biomarkers: A Systematic Review

Paras Ahmad et al.

Summary: Salivary proteins play an important role in the repair of damaged tissues and the maintenance of oral health. This systematic review aimed to assess the association between caries and salivary proteins by comparing caries-free (CF) and caries-active (CA) individuals. The results showed that the levels of certain salivary proteins were significantly increased in CA patients, while others were significantly increased in CF subjects. However, there were conflicting results regarding the salivary levels of immunoglobulin-A and total proteins among CA and CF subjects. Due to significant heterogeneity among the included studies, no meta-analysis could be performed. Therefore, larger prospective studies are needed to verify the diagnostic value of salivary proteins as biomarkers for caries.

CARIES RESEARCH (2022)

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Review Dentistry, Oral Surgery & Medicine

The impact of COVID-19 on individual oral health: a scoping review

Virginia Dickson-Swift et al.

Summary: This scoping review study investigated the impact of COVID-19 on individual oral health, finding that the pandemic has significantly affected oral health, highlighting areas such as emergency dental services, routine oral health services, and home oral hygiene maintenance. It is crucial to have support systems in place to overcome periods where access to dental care might be compromised in the future.

BMC ORAL HEALTH (2022)

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Review Environmental Sciences

Pandemic COVID-19 Influence on Adult's Oral Hygiene, Dietary Habits and Caries Disease-Literature Review

Aleksandra Wdowiak-Szymanik et al.

Summary: The COVID-19 pandemic has significantly affected people's dietary habits and has had an uncertain impact on oral health habits. Patients have limited their visits to necessary ones due to fear of infection.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Food Science & Technology

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Alessia Catalano et al.

Summary: The importance of post-COVID syndrome has increased due to the reduction of severe cases and deaths from COVID-19. Nutraceutical products have attracted great interest in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.

FOODS (2022)

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Article Dentistry, Oral Surgery & Medicine

Extended biofilm formation time by Streptococcus sanguinis modifies its non- cariogenic behavior, in vitro

Natalia Diaz-Garrido et al.

Summary: This study investigated the cariogenic potential of S. sanguinis strains in vitro, based on different enamel biofilm formation times. The results showed that S. sanguinis had a lower cariogenic potential compared to S. mutans, but an increased formation time of biofilms on enamel by S. sanguinis contributed to an increase in cariogenic potential.

BRAZILIAN ORAL RESEARCH (2022)

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Review Engineering, Biomedical

Important Roles and Potential Uses of Natural and Synthetic Antimicrobial Peptides (AMPs) in Oral Diseases: Cavity, Periodontal Disease, and Thrush

Albert Donald Luong et al.

Summary: Epithelial cells and leukocytes release AMPs as a defense mechanism against oral pathogens. However, the concentrations of AMPs are low and they are unstable under physiological conditions. Efforts have been made to synthesize stable and low-cytotoxicity AMPs and improve their antimicrobial activity using nanomaterials and biomolecules. Future research should focus on developing AMPs that promote remineralization and antibacterial adhesion. Nanostructured AMPs are a promising alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis and modification.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

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Review Multidisciplinary Sciences

Diagnostic accuracy, available treatment, and diagnostic methods of dental caries in practice: a meta-analysis

Mona Momeni-Moghaddam et al.

Summary: This article reviewed the research data on dental caries from the past 50 years and identified preventive methods for dental caries. The study suggests that attentive parents and caretakers can help reduce the occurrence of dental caries in children.

BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES (2022)

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Article Dentistry, Oral Surgery & Medicine

Streptococcus mutans and Streptococcus sobrinus distribution in the saliva and plaque of Iranian population: Higher prevalence of S. mutans serotypes f and k

Laleh Babaeekhou et al.

Summary: This study found that there are different serotypes of S. mutans in the Iranian population, with participants carrying serotype e having significantly higher DMFT scores than other serotypes. Individuals with S. mutans had higher DMFT scores compared to those without S. mutans, and there was a high prevalence of serotype k.

INTERNATIONAL JOURNAL OF DENTAL HYGIENE (2021)

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Review Chemistry, Multidisciplinary

Diarylureas as Antitumor Agents

Alessia Catalano et al.

Summary: Diarylurea is a crucial scaffold in medicinal chemistry, found in various heterocyclic compounds with properties such as antithrombotic, antimalarial, antibacterial, and anti-inflammatory. Recent literature has reported diarylureas as inhibitors of serine-threonine kinase or tyrosine kinase. The first diarylurea to be marketed as an anticancer agent was sorafenib, with others following suit. This review explores the progress made in the past decade in developing new diarylureas as anticancer agents.

APPLIED SCIENCES-BASEL (2021)

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Review Infectious Diseases

Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics

Alessia Catalano et al.

Summary: Antimicrobials have played a significant role in advancing medical treatments, but the emergence of antimicrobial resistance poses challenges in treating infectious diseases. The identification of new coronavirus variants, such as the one in the UK, underscores the urgent need for safe and potent antimicrobials and antivirals. Efforts to develop multitarget therapeutic strategies using compounds like diarylureas are seen as promising for combating new pandemic events.

ANTIBIOTICS-BASEL (2021)

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Review Dentistry, Oral Surgery & Medicine

Antimicrobial peptides for the prevention and treatment of dental caries: A concise review

John Yun Niu et al.

Summary: This study identified 67 publications reporting seven natural and 43 synthetic antimicrobial peptides for the prevention and treatment of dental caries. Most of the antimicrobial peptides showed bactericidal effects, some were effective in preventing bacterial adhesion. A few antimicrobial peptides also displayed remineralising properties with hydroxyapatite.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Infectious Diseases

Searching for Small Molecules as Antibacterials: Non-Cytotoxic Diarylureas Analogues of Triclocarban

Alessia Catalano et al.

Summary: TCC, a commonly used antimicrobial agent, has been banned by the U.S. FDA in certain consumer wash products due to its toxicity. The withdrawal of TCC has led to the search for new antimicrobial compounds, with compounds 1ab and 1bc showing similar or higher activity compared to TCC, without exhibiting cytotoxicity towards human cells.

ANTIBIOTICS-BASEL (2021)

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Review Microbiology

Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides

Yongwang Lin et al.

Summary: This review summarizes plausible strategies targeting Streptococcus mutans biofilms by degrading EPS structure, inhibiting EPS production, and disturbing the EPS metabolism-related gene expression and regulatory systems.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Review Dentistry, Oral Surgery & Medicine

The global prevalence of early childhood caries: A systematic review with meta-analysis using the WHO diagnostic criteria

Sergio E. Uribe et al.

Summary: Early childhood caries is a global health issue, affecting nearly half of preschool children. The prevalence of ECC varies widely across countries, with differences between countries explaining a significant amount of observed variance.

INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY (2021)

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Article Pediatrics

Comparison of Antimicrobial Activity of Fluoride Varnishes Against Streptococcus mutans and Lactobacillus acidophilus: An In Vitro Study

Banafsheh Soleimani et al.

Summary: The study investigated the antibacterial effects of three common fluoride varnishes on two cariogenic bacteria, with MI varnish showing the highest efficacy in preventing tooth decay.

IRANIAN JOURNAL OF PEDIATRICS (2021)

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Review Microbiology

Small Molecule Compounds, A Novel Strategy against Streptococcus mutans

Sirui Yang et al.

Summary: Dental caries is a global public health issue caused primarily by oral biofilms, with Streptococcus mutans being a major causative factor. In addition to mechanical removal, topical application of antimicrobial agents is crucial for caries control, but existing agents have limitations. Antimicrobial small molecules show promise for controlling S. mutans due to their good activity, selectivity, and low toxicity.

PATHOGENS (2021)

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Review Biochemistry & Molecular Biology

The Different Facets of Triclocarban: A Review

Domenico Iacopetta et al.

Summary: Triclocarban, a polychlorinated aromatic antimicrobial agent, has been widely used in various products for over 50 years, but concerns about its endocrine disruptive properties have led to a ban by the U.S. Food and Drug Administration in hand and body washes. Efforts are now being made to find alternative antimicrobial compounds.

MOLECULES (2021)

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Article Microbiology

Anti-Bacterial Properties of Cannabigerol Toward Streptococcus mutans

Muna Aqawi et al.

Summary: CBG exhibits antibacterial activities against S. mutans by altering membrane structures and properties, increasing membrane permeability, reducing metabolic activity, and preventing pH drop caused by the bacteria.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Oncology

Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries

Maira Terra-Garcia et al.

Summary: Photodynamic therapy using the novel photosensitizer FTC showed promising control effects against clinical strains of S. mutans. The study demonstrated that PDT can effectively eliminate cariogenic pathogens and significantly reduce different types of cariogenic strains in biofilms.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Multidisciplinary Sciences

Association of Candida albicans and Cbp+Streptococcus mutans with early childhood caries recurrence

B. A. Garcia et al.

Summary: The study found that Streptococcus mutans carrying collagen-binding proteins and Candida albicans are closely related to the recurrence of early childhood caries, particularly strongly associated with caries recurrence. Children in the recurrence group infected with Cbp(+)S. mutans had a heavier burden of Candida spp. and Mutans streptococci in dentin, while Streptococcus parasanguinis was overrepresented in the salivary microbiome of the caries recurrence group.

SCIENTIFIC REPORTS (2021)

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Article Infectious Diseases

Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity

Alessia Catalano et al.

Summary: Triclocarban is a widely used antimicrobial agent with potential environmental impact. Researchers have been studying the synthesis and biological activity of new compounds to replace TCC, and some analogues have shown higher antimicrobial activity against bacteria such as Staphylococcus aureus and Enterococcus faecalis. Compound 2bG also exhibited interesting bactericidal action despite being less active than others.

ANTIBIOTICS-BASEL (2021)

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Article Chemistry, Multidisciplinary

Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones

Yonggui Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Dentistry, Oral Surgery & Medicine

The use of silver diamine fluoride (SDF) in dental practice

Nassar Seifo et al.

BRITISH DENTAL JOURNAL (2020)

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Review Dentistry, Oral Surgery & Medicine

Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study

E. Bernabe et al.

JOURNAL OF DENTAL RESEARCH (2020)

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Review Toxicology

Principles of fluoride toxicity and the cellular response: a review

Nichole R. Johnston et al.

ARCHIVES OF TOXICOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Application of Antibiotics/Antimicrobial Agents on Dental Caries

Wei Qiu et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Infectious Diseases

Alternative approaches to treat bacterial infections: targeting quorum-sensing

Pipat Piewngam et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2020)

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Review Engineering, Multidisciplinary

Stannous Fluoride Effects on Enamel: A Systematic Review

Luca Fiorillo et al.

BIOMIMETICS (2020)

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Review Microbiology

Resistance Toward Chlorhexidine in Oral Bacteria - Is There Cause for Concern?

Fabian Cieplik et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Cross-kingdom interaction of Candida albicans and Actinomyces viscosus elevated cariogenic virulence

Ling Deng et al.

ARCHIVES OF ORAL BIOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Fluoride Revolution and Dental Caries: Evolution of Policies for Global Use

H. P. Whelton et al.

JOURNAL OF DENTAL RESEARCH (2019)

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Article Medicine, General & Internal

Oral diseases: a global public health challenge

Marco A. Peres et al.

LANCET (2019)

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Article Biotechnology & Applied Microbiology

Effects of Fluoride and Calcium Phosphate Materials on Remineralization of Mild and Severe White Spot Lesions

Zixiang Dai et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Review Dentistry, Oral Surgery & Medicine

Guidelines on the use of fluoride for caries prevention in children: an updated EAPD policy document

K. J. Toumba et al.

EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY (2019)

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Review Microbiology

Streptococcus sanguinis biofilm formation & interaction with oral pathogens

Bin Zhu et al.

FUTURE MICROBIOLOGY (2018)

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Review Medicine, Research & Experimental

Toxic effects of fluoride on organisms

Huan Zuo et al.

LIFE SCIENCES (2018)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

LANCET (2018)

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Article Biochemistry & Molecular Biology

Pentafluorosulfanyl-containing Triclocarban Analogs with Potent Antimicrobial Activity

Eugenia Pujol et al.

MOLECULES (2018)

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Article Chemistry, Physical

Arrest of Root Carious Lesions via Sodium Fluoride, Chlorhexidine and Silver Diamine Fluoride In Vitro

Gerd Goestemeyer et al.

MATERIALS (2018)

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Review Dentistry, Oral Surgery & Medicine

Advances in the microbial etiology and pathogenesis of early childhood caries

E. Hajishengallis et al.

MOLECULAR ORAL MICROBIOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Efficacy of Fluoride Varnishes with Added Calcium Phosphate in the Protection of the Structural and Mechanical Properties of Enamel

Mahdi Shahmoradi et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Immunology

Inhibition of the Quorum Sensing System (ComDE Pathway) by Aromatic 1,3-di-m-tolylurea (DMTU): Cariostatic Effect with Fluoride in Wistar Rats

Gurmeet Kaur et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Article Medicine, General & Internal

Dental caries

Nigel B. Pitts et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Microbiology

Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence

Zhi Ren et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

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Article Biochemistry & Molecular Biology

Diaryl Urea: A Privileged Structure in Anticancer Agents

Laura Garuti et al.

CURRENT MEDICINAL CHEMISTRY (2016)

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Review Dentistry, Oral Surgery & Medicine

Global burden of oral diseases: emerging concepts, management and interplay with systemic health

L. J. Jin et al.

ORAL DISEASES (2016)

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Article Microbiology

Combinatorial Effects of Aromatic 1,3-Disubstituted Ureas and Fluoride on In vitro Inhibition of Streptococcus mutans Biofilm Formation

Gurmeet Kaur et al.

FRONTIERS IN MICROBIOLOGY (2016)

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Article Microbiology

Proteomic Analyses of Chlorhexidine Tolerance Mechanisms in Delftia acidovorans Biofilms

Tara Rema et al.

MSPHERE (2016)

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Article Multidisciplinary Sciences

Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness

Jin Xiao et al.

PLOS ONE (2016)

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Article Biochemistry & Molecular Biology

Small Molecule Fluoride Toxicity Agonists

James W. Nelson et al.

CHEMISTRY & BIOLOGY (2015)

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Article Microbiology

Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm

Matilde Ruiz-Linares et al.

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