4.6 Article

The Anti-Virulence Effect of Vismia guianensis against Candida albicans and Candida glabrata

期刊

ANTIBIOTICS-BASEL
卷 11, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/antibiotics11121834

关键词

Vismia guianensis; Candida albicans; vismione D; Candida glabrata; CaCYP51; antifungals; lacre

资金

  1. FAPEMA (Fundacao de Amparo a Pesquisa do Maranhao) as part of State Institute of Research in Biotechnology
  2. CNPq (Conselho Nacional de Desenvolvimento e Tecnologico) [IECT-02885/17]
  3. CAPES
  4. [01]

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This study evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis and found that it inhibited the virulence factors of the fungi. The main compound responsible for this activity was identified as vismione D.
In folk medicine, Vismia guianensis is used to treat skin diseases and mycoses in the Amazon region. We evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis (EHVG). HPLC-PDA and FIA-ESI-IT-MSn were used to chemically characterize EHVG. The anti-Candida activity was determined in vitro by the minimum inhibitory concentrations (MIC) against Candida glabrata (ATCC-2001); Candida albicans (ATCC-90028, ATCC-14053, and ATCC-SC5314), and C. albicans clinical isolates. EHVG effects on adhesion, growth, and biofilm formation were also determined. Molecular docking was used to predict targets for EHVG compounds. The main compounds identified included anthraquinone, vismione D, kaempferol, quercetin, and vitexin. EHVG was fungicidal against all tested strains. C. albicans ATCC 14053 and C. glabrata ATCC 2001 were the most sensitive strains, as the extract inhibited their virulence factors. In silico analysis indicated that vismione D presented the best antifungal activity, since it was the most effective in inhibiting CaCYP51, and may act as anti-inflammatory and antioxidant agent, according to the online PASS prediction. Overall, the data demonstrate that EHVG has an anti-Candida effect by inhibiting virulence factors of the fungi. This activity may be related to its vismione D content, indicating this compound may represent a new perspective for treating diseases caused by Candida sp.

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