A Post Hoc Analysis of Efficacy Data on Sarecycline in Hispanics with Acne from Two Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trials

Letter Dermatology

Differences in risk of tetracycline- associated hyperpigmentation between racial and ethnic groups in patients with acne vulgaris: A national US retrospective study

Katherine Young et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2023)

Review Oncology

A Focused review on the pathophysiology of post-inflammatory hyperpigmentation

Jalal Maghfour et al.

Summary: Post-inflammatory hyperpigmentation (PIH) is a common acquired disorder characterized by increased melanin production. The exact mechanisms underlying PIH are not fully understood. This article reviews the current evidence on the pathophysiology of PIH, aiming to provide insights for the development of targeted therapies.

PIGMENT CELL & MELANOMA RESEARCH (2022)

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Article Microbiology

Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota

Ines B. Moura et al.

Summary: This study investigated the impact of prolonged exposure to sarecycline compared to broad-spectrum tetracyclines on the colonic microbiota. The results showed that sarecycline had minimal and transient effects on the gut microbiota composition and diversity, when compared to minocycline and doxycycline.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Infectious Diseases

Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota

Mahmoud A. Ghannoum et al.

Summary: This study evaluated the impact of sarecycline on gut microbiota and found that it had reduced antimicrobial activity compared to minocycline against a wide range of microorganisms. This suggests that sarecycline is less disruptive to gut microbiota.

ANTIBIOTICS-BASEL (2022)

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Review Microbiology

Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions

Mikhail Syromyatnikov et al.

Summary: High-throughput sequencing has enabled extensive studies on the human gut microbiota. This review analyzes the connection between the gut microbiome and the nationality and religion of individuals. The findings suggest that the gut microbiome composition varies among different ethnic groups and religions, potentially influenced by food preferences. The review also discusses the influence of various pathologies on the bacterial composition of the gut.

MICROORGANISMS (2022)

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Article Biochemistry & Molecular Biology

Molecular and Biochemical Basis of Minocycline-Induced Hyperpigmentation-The Study on Normal Human Melanocytes Exposed to UVA and UVB Radiation

Jakub Rok et al.

Summary: The study showed that minocycline can enhance melanin synthesis and this effect is intensified by irradiation, especially with the UVB spectrum. The results confirmed the potential role of melanin and UV radiation in minocycline-induced skin hyperpigmentation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Dermatology

The Pathogenesis and Management of Acne-Induced Post-inflammatory Hyperpigmentation

Nada Elbuluk et al.

Summary: Acne vulgaris can lead to pigmentary sequelae such as post-inflammatory hyperpigmentation and erythema, which are more distressing to patients than the active acne lesions. A working group of pigmentary experts has been formed to increase awareness and education of acne-related pigmentation due to its clinical concern and therapeutic challenge.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

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Review Dermatology