期刊
ANTIBIOTICS-BASEL
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics12010089
关键词
acne vulgaris; skin color; tetracycline; sarecycline; Hispanic
This study aimed to analyze the efficacy of using sarecycline in Hispanics with moderate-to-severe acne. The results showed a significant reduction in facial inflammatory lesion counts in Hispanic patients with acne treated with oral sarecycline for 12 weeks. Therefore, oral sarecycline shows promising results as a safe and effective treatment for acne in Hispanics.
Sarecycline is a novel, narrow-spectrum, third generation tetracycline class antibiotic approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe acne in patients ages nine and older. Recently, focus has increased on whether treatment responses differ in acne in skin of color. Here, we aimed to analyze the efficacy of using sarecycline in Hispanics. We report pooled post hoc analysis of efficacy data on sarecycline in Hispanics with acne from two phase 3, multicenter, randomized, double-blind, placebo-controlled clinical trials, SC1401 and SC1402. Of 2002 patients in the pooled trials with moderate-to-severe acne, 26.9% were Hispanic. Facial inflammatory lesion counts decreased as early as week 3 by 26% (p = 0.0279), with continued reduction by 41% by week 6 (p = 0.0003), by 51% by week 9 (p < 0.0001), and by 55% by week 12 (p < 0.0001). Acne is the most common skin condition diagnosed in Hispanics, and this study illustrates a statistically significant reduction in acne in Hispanic patients with moderate-to-severe acne treated with oral sarecycline. Therefore, oral sarecycline shows promising results as a safe and effective treatment for acne in Hispanics.
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