期刊
ANTIBIOTICS-BASEL
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11111645
关键词
bacterial resistance; Campylobacter jejuni; metal-based drugs; platinum(II) complexes; synergism
资金
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brasil) [001]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [442778/2016-3]
This work synthesized and characterized two metal complexes and investigated their antibacterial activity against Campylobacter jejuni in combination with antibiotics. The results showed that complex I exhibited a promising alternative for controlling resistant strains of C. jejuni.
This work describes the synthesis and characterization of two metal complexes of the type [M(L-1)(2)(phen)], where M = Pt2+ (complex I) or Pd2+ (complex II), L-1 = 5-amino-1,3,4-thiadiazole-2(3H)-thiolate and phen = 1,10-phenanthroline. The in vitro antibacterial activity of these complexes was investigated in isolation and synergistically with ciprofloxacin (CIP) and erythromycin (ERY) in three strains of Campylobacter jejuni (MIC = 32 mg/L for CIP and ERY), selected from a bank of 235 strains representative of three poultry exporting states of the country (A, B and C), previously analyzed for epidemiology and resistance to CIP and ERY. A total of 53/235 (22.55%) strains showed co-resistance to CIP and ERY. Isolated resistance to CIP was higher than to ERY. Epidemiological analysis showed that resistance to CIP was more evident in state B (p < 0.0001), as well as a higher susceptibility to ERY in state C (p = 0.0028). Co-resistance was expressive in state A and in the spring and fall seasons. The evaluation of I alone and in synergy with CIP and ERY found values up to 0.25 mg/L not significant for ERY. Complex II did not show an antimicrobial effect on the three strains of tested C. jejuni. The effect provided by complex I represents a promising alternative for control of resistant strains of C. jejuni.
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