☆ 4.6 Review

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

ANTIBIOTICS-BASEL (2022)

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Article Engineering, Environmental

A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration

Guannan Zhang et al.

Summary: This study developed a rare-earth elements-doped nano-shovel/quercetin/L-arginine coating with photothermal conversion, ROS generation, and NO release capabilities, which can inhibit bone tumor growth and eliminate biofilms on implants while promoting new bone tissue formation.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Materials Science, Biomaterials

Advancing of 3D-Printed Titanium Implants with Combined Antibacterial Protection Using Ultrasharp Nanostructured Surface and Gallium-Releasing Agents

Shaheer Maher et al.

Summary: This study developed advanced Ti implants with enhanced antibacterial activity using 3D printing technology and surface modification with gallium nitrate. The implants showed significant antibacterial performance against Staphylococcus aureus and Pseudomonas aeruginosa, achieving 100% eradication of bacteria. The combination of sharp nanopillars and locally releasing gallium ions on the fabricated substrates demonstrated effective antibacterial properties and dual cytocompatibility for future implant engineering.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Engineering, Environmental

Surface modification of titanium implants by pH-Responsive coating designed for Self-Adaptive antibacterial and promoted osseointegration

Fanjun Zhang et al.

Summary: A pH-sensitive antibacterial copolymer was successfully synthesized and coated onto the surface of titanium metal to construct an antibacterial coating. The coating demonstrated dual functions of antibacterial and promoting osseointegration. In in vivo experiments, the coated screws showed good abilities of antibacterial and anti-inflammatory of implantation, as well as good osteointegration performance.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Materials Science, Multidisciplinary

Nanosurface modification of Ti64 implant by anodic fluorine-doped alumina/titania for orthopedic application

Zhende Zhao

Summary: This study presents a new hybrid approach to improve the performance of titanium-based alloys by developing a fluorine-doped alumina/titania coating. The impact of surface tuning on the in-vitro bioactivity of the implant was evaluated. Experimental observations confirmed the effectiveness of the nanosurface modification in enhancing the mechanical performance, wettability, and in vitro bioactivity of the system.

MATERIALS CHEMISTRY AND PHYSICS (2022)

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Article Materials Science, Coatings & Films

Early osseointegration of strontium-doped coatings on titanium implants in an osteoporotic rat model

Maria Rosa Katunar et al.

Summary: This study assessed the in vivo performance of a surface modification consisting of a bioactive silica-based layer with strontium-doped bioactive glass particles on titanium nail-shaped implants in osteoporotic rats. The results showed that the bioactive Sr-glass coatings had a positive effect on new bone tissue formation.

SURFACE & COATINGS TECHNOLOGY (2022)

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Article Multidisciplinary Sciences

Low voltage environmentally friendly plasma electrolytic oxidation process for titanium alloys

Fengyan Hou et al.

Summary: We report an environmentally friendly PEO process that uses nitrogen-containing electrolytes and low voltages to form uniform, adherent and porous oxide coatings on titanium alloy surfaces. The coatings primarily consist of titanium oxides and silicates. Nitrogen-based compounds improve the hardness of the oxide layers but may reduce the corrosion resistance of the coatings.

SCIENTIFIC REPORTS (2022)

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Article Engineering, Biomedical

Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection

Jingwei Hu et al.

Summary: This study constructed a surface-functionalized titanium implant using mesoporous polydopamine nanoparticles and a calcium phosphate shell. The implant exhibited effective antibacterial and osseointegration capabilities through a combination of photothermal therapy and quorum sensing inhibition strategy. The modified titanium substrate accelerated cell growth and bone tissue healing, making it a promising approach for clinical application in treating bacterial biofilm infection.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Physical

Rare transition metal doped hydroxyapatite coating prepared via microwave irradiation improved corrosion resistance, biocompatibility and anti-biofilm property of titanium alloy

Sikta Panda et al.

Summary: Niobium doped hydroxyapatite coatings were synthesized on titanium alloy sheets via microwave irradiation, improving the biocompatibility and corrosion resistance of the substrate with excellent antibiofilm function. The doped coatings were denser, thicker, and more crystalline, with increased surface roughness and hydrophilicity. The corrosion resistance of the substrates was greatly improved by the doping. The presence of niobium in the coating enhanced protein adsorption and cell survival on the apatite layer. The coating exhibited anti-biofilm property against gram-negative and gram-positive bacteria strains.

JOURNAL OF ALLOYS AND COMPOUNDS (2022)

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Review Crystallography

Crystalline Zeolite Layers on the Surface of Titanium Alloys in Biomedical Applications: Current Knowledge and Possible Directions of Development

Marcel Jakubowski et al.

Summary: This review focuses on the use of zeolites as layers to modify the surface of titanium implants. It discusses the methods for modifying zeolite properties and their biomedical applications. The review presents examples of surface modifications of titanium alloys with zeolites and highlights the significant impact on implant properties.

CRYSTALS (2022)

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Article Chemistry, Multidisciplinary

Functional silver nanoparticles as broad-spectrum antimicrobial agents

Juan Zhang et al.

Summary: Drug resistance is a global issue, and it is urgent to develop a new antibacterial agent that can fight drug-resistant bacteria without causing resistance. In this study, indole functionalized silver nanoparticles (Ag NPs) were synthesized to combat drug-resistant bacteria. The modified silver nanoparticles (5NI-Ag NPs and Try-Ag NPs) showed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria. Particularly, Try-Ag NPs exhibited better antibacterial activity against both normal and drug-resistant bacteria, with low minimum inhibitory concentrations. Moreover, resistance generation towards Try-Ag NPs was not easily observed.

NEW JOURNAL OF CHEMISTRY (2022)

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Article Engineering, Biomedical

Cu2+ Release from Polylactic Acid Coating on Titanium Reduces Bone Implant-Related Infection

Chengdong Zhang et al.

Summary: This study explored a strategy for releasing copper ions from titanium implants and evaluated its feasibility in clinical translation. The results showed that PLA coatings containing copper ions exhibited strong antibacterial activity and did not adversely affect adjacent bone healing.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

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Article Engineering, Environmental

Thermo and light-responsive strategies of smart titanium-containing composite material surface for enhancing bacterially anti-adhesive property

Jing Lin et al.

Summary: This study focused on designing a composite material surface with smart response to adjust and enhance bacterial anti-adhesion by thermo and light-responsive strategies. The composite surface was demonstrated to greatly reduce bacterial adhesion by incorporating long-lasting antibacterial and hydrophilic constituents. The durable properties of antibacterial and bacterial anti-adhesive effects make it suitable for applications in mutable environments.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Materials Science, Biomaterials

Organic and inorganic antibacterial approaches in combating bacterial infection for biomedical application

Syafiqah Saidin et al.

Summary: This review paper explores the potential applications of inorganic and organic antibacterial agents in biomedical settings, discussing their mechanisms of action on Gram-negative and Gram-positive bacteria. Inorganic agents like silver, copper, gold, and zinc release ions to target Gram-negative bacteria, while organic agents like chlorhexidine and triclosan disrupt biochemical pathways in Gram-positive bacteria. The selection of antibacterial agents for biomaterials should consider their effective mechanisms and the specific bacterial strains they are targeting.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Microbiology

Staphylococcus aureus biofilms: an opportunistic pathogen with multidrug resistance

Giorgio Silva-Santana et al.

Summary: Research on bacterial biofilm formation is crucial due to its connection with various human diseases. Staphylococcus aureus is known for its ability to form biofilms, leading to infections like endocarditis and sepsis. This study aims to explore the main aspects of biofilm formation by S. aureus.

REVIEWS IN MEDICAL MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection-Responsive Antibacterial Agent

Yunfei Zhang et al.

Summary: An antimicrobial coating with a peptide sequence sensitive to S. aureus was designed in this study, allowing for the release of antibiotics specifically when an infection occurs by recognizing and cleaving the peptide by an enzyme secreted by S. aureus.

MACROMOLECULAR BIOSCIENCE (2021)

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Review Engineering, Biomedical

Corrosion of titanium under simulated inflammation conditions: clinical context and in vitro investigations

M. Prestat et al.

Summary: This review article discusses the in vitro corrosion of titanium and alloys under inflammation conditions, emphasizing the role of reactive oxygen species in degrading the passive layer protecting titanium implants. Inflammation contributes to the deterioration of biomedical devices, leading to health issues and implant failure. The review highlights the importance of electrochemical and microstructural aspects in understanding this process.

ACTA BIOMATERIALIA (2021)

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Article Biophysics

Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin

Jiayue Sun et al.

Summary: The study introduces a graphene coating to modified titanium surfaces to prevent bacterial infections in oral implants, showing promising antibacterial effects in both in vitro and in vivo tests. The graphene coating, when loaded with levofloxacin, exhibits synergistic antibacterial properties through membrane stress and ROS generation, effectively preventing bacterial infections following implantation.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Engineering, Biomedical

A functional coating to enhance antibacterial and bioactivity properties of titanium implants and its performance in vitro

Burcu Doymus et al.

Summary: A functional coating composed of chitosan microspheres and nano hydroxyapatite was prepared to enhance the antimicrobial and bioactive properties of titanium implants. The choice of drug release rate and nHA precipitation both influenced the antimicrobial activity of the modified surfaces, with the best results seen in samples without nHA layer and when the drug was loaded by diffusion.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

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Article Engineering, Biomedical

Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

Gabriela Graziani et al.

Summary: This study demonstrates that nanostructured antibacterial and bioactive thin films obtained by Ionized Jet Deposition show promising potential for orthopedic implant applications, with significant antimicrobial efficacy against various bacterial strains and fungus while maintaining good biocompatibility. The deposition process allows for fine control over film composition and morphology, and the coatings exhibit suitable mechanical properties for implant integration.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature

Guannan Zhang et al.

Summary: A near-infrared II (NIR-II) phototherapy system, incorporating nanoparticles and active substances, has been developed to overcome the challenges of light-triggered therapy. By utilizing laser of specific wavelength, it can rapidly eliminate bacterial biofilms on titanium surfaces in vitro and in vivo, promoting osteogenic differentiation and new bone formation.

BIOMATERIALS (2021)

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Article Dentistry, Oral Surgery & Medicine

Race to invade: Understanding soft tissue integration at the transmucosal region of titanium dental implants

Tianqi Guo et al.

Summary: This article discusses the structural and histological characteristics of peri-implant tissues, compares the inferior STI quality of conventional smooth and bio-inert titanium-based transmucosal components, and explores the material-based challenges to achieve robust STI.

DENTAL MATERIALS (2021)

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Article Chemistry, Applied

Drug-release dynamics and antibacterial activities of chitosan/cefazolin coatings on Ti implants

Shyi-Tien Chen et al.

Summary: Chitosan/drug coatings synthesized via electrophoretic deposition on alkali-treated Ti surfaces exhibited improved antibacterial activities and corrosion resistances. With desirable adhesion, high drug loading capacity, and prolonged drug release, these proposed coatings can effectively limit bacterial adhesion and proliferation on Ti surfaces.

PROGRESS IN ORGANIC COATINGS (2021)

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Article Orthopedics

The antimicrobial activity and biocompatibility of a controlled gentamicin-releasing single-layer sol-gel coating on hydroxyapatite-coated titanium

T. Nichol et al.

Summary: This study aimed to develop a controlled antibiotic release single-layer hybrid organic-inorganic sol-gel coating for cementless hydroxyapatite-coated titanium orthopaedic prostheses. Both laboratory and in vivo tests showed promising results in terms of antibiotic release kinetics, antibacterial activity, biocompatibility, physical bonding, and osseointegration. The sol-gel coating demonstrated rapid and effective antibiotic release, as well as successful eradication of bacterial biofilms and promotion of osteoblast differentiation in vitro and in vivo, suggesting its potential in preventing implant-related deep infection.

BONE & JOINT JOURNAL (2021)

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Review Crystallography

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Hui Shi et al.

Summary: Hydroxyapatite is widely used in bone tissue engineering for its bioactivity and biocompatibility, with researchers exploring ways to improve its physical properties and biological functions. Functionalized HA has been prepared using methods such as ion doping and surface modification, and applications in bone tissue engineering have been discussed in this review. The review provides a general understanding of the development of hydroxyapatite-based materials for researchers.

CRYSTALS (2021)

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Article Materials Science, Multidisciplinary

Preparation of Coating on the Titanium Surface by Micro-Arc Oxidation to Improve Corrosion Resistance

Yulong Hu et al.

Summary: The study found that MAO treatment can significantly enhance the corrosion resistance of TA2. However, increasing the thickness of the MAO coating does not further improve the corrosion resistance. Additionally, due to the increase in effective surface area, the MAO treatment may enhance the cathode action of TA2, promoting the corrosion of more negative metals in a galvanic cell.

COATINGS (2021)

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Article Nutrition & Dietetics

Iodine: Its Role in Thyroid Hormone Biosynthesis and Beyond

Salvatore Sorrenti et al.

Summary: In addition to its role in the synthesis of thyroid hormones, iodine acts as an antioxidant, defends against pathogens, and has anti-cancer effects in human cell lines. Its oxidation to hypoiodite has been shown to have bactericidal, antiviral, and antifungal properties. Through tissue-specific peroxidases, iodine serves various evolutionarily conserved physiological functions.

NUTRIENTS (2021)

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Article Engineering, Biomedical

Osseointegration and antibacterial effect of an antimicrobial peptide releasing mesoporous titania implant

Maria Pihl et al.

Summary: This study found that using mesoporous titania-covered titanium implants as a new strategy for antibiofilm efficacy with AMP RRP9W4N can sustainably release and have good antibiofilm properties, with no negative impact on osseointegration.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

Xiaoxuan Lu et al.

Summary: Titanium and its alloys are widely used in orthopedic and dental implants due to their stable chemical properties and good biocompatibility. However, issues such as aseptic loosening and peri-implant infection still exist. Recent advancements in surface modification have provided strategies to enhance the bio-function and anti-infection properties of titanium implants, aiming to improve the interaction between these devices and the local biological environment.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Materials Science, Multidisciplinary

Melittin antimicrobial peptide thin layer on bone implant chitosan-antibiotic coatings and their bactericidal properties

Vahid Zarghami et al.

Summary: The study demonstrated that a combination of chitosan, antibiotics, and Melittin coated on bone implants can effectively eradicate antibiotic resistant bacteria and biofilm formation. A concentration of Melittin higher than 0.2μg/mL exhibited better bactericidal effects, but also showed toxicity to bone cells. The synergistic effect of antibiotics and Melittin can prevent antibiotic resistant bacterial infections and biofilm formation without toxicity.

MATERIALS CHEMISTRY AND PHYSICS (2021)

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Article Chemistry, Physical

Biofilm Formation on Dental Implant Biomaterials by Staphylococcus aureus Strains Isolated from Patients with Cystic Fibrosis

Anna Minkiewicz-Zochniak et al.

Summary: This study evaluated the differences in in vitro biofilm formation on the surface of biomaterials commonly used in dentistry by Staphylococcus aureus isolated from patients with cystic fibrosis. Results showed that S. aureus adherence and growth depend on the type of material used and its surface topography, with weaker bacterial biofilm formation observed on zirconia surfaces.

MATERIALS (2021)

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Article Materials Science, Multidisciplinary

Structural, morphological and biological evaluations of cerium incorporated hydroxyapatite solegel coatings on Ti-6Al-4V for orthopaedic applications

B. Priyadarshini et al.

Summary: This study aimed to improve the bio-functions and corrosion resistance of titanium alloys by applying cerium incorporated hydroxyapatite coatings. The Ce-HAP coatings exhibited significant inhibition efficiency towards pathogens and excellent apatite layer formation, making them essential for desired biomedical applications. The electrochemical properties analysis showed pronounced anti-corrosion property of the coatings.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Article Biochemistry & Molecular Biology

Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration

Tomas Suchy et al.

Summary: The study shows that COLHA+V layers can significantly prevent bone structure destruction caused by bacterial infection with minimal systemic load, while enhancing the rate of bone and implant integration.

BIOMEDICINES (2021)

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Article Nanoscience & Nanotechnology

Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium

Lan Zhang et al.

Summary: Titanium is commonly used in medical implants due to its mechanical strength and biocompatibility. Recent studies have focused on developing coatings to enhance the properties of Ti implants, with Ca- and Si-based ceramic coatings being able to release ions to improve bone integration. However, the high degradation rates of these ceramics may reduce cell viability, requiring the use of polymeric or protein-based coatings to modulate degradation while maintaining stability and biocompatibility.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Microbiology

An in vitro antiviral activity of iodine complexes against SARS-CoV-2

Imran Altaf et al.

Summary: The study demonstrates that Renessans, a complex of iodine, shows significant inhibitory activity against SARS-CoV-2 in a non-toxic manner, which might be further explored in human clinical trials.

ARCHIVES OF MICROBIOLOGY (2021)

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Article Engineering, Environmental

Poly(hexamethylene biguanide) (PHMB) as high-efficiency antibacterial coating for titanium substrates

Jiangmei Peng et al.

Summary: A new strategy was developed to combat bacterial associated infection on titanium alloy surfaces, resulting in a polymer coating that can kill 100% of both S. aureus and E. coli without compromising cytocompatibility. The coating could significantly inhibit bacterial colony growth and reduce inflammatory reactions, as verified in a rat infection model.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Multidisciplinary Sciences

Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi et al.

Summary: The authors present a prophylactic coating technology that can incorporate various antibiotics and be applied in vivo prior to implantation, effectively preventing joint implant infections.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

Shuyi Wu et al.

Summary: Ti implantation infection is a major threat to the success of dental implants, with coatings on Ti surfaces losing their antibacterial efficacy rapidly. The N-halamine polymeric coating presented in this study demonstrates long-lasting renewable antibacterial efficacy, providing a promising solution for prevention and treatment of peri-implant infection.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Iodine-Loaded Calcium Titanate for Bone Repair with Sustainable Antibacterial Activity Prepared by Solution and Heat Treatment

Seiji Yamaguchi et al.

Summary: The study developed a new method to incorporate iodine into titanium and its alloys, enhancing their antibacterial properties and demonstrating strong antibacterial activity against various bacteria. The treated metals showed long-term stability in antibacterial activity and cytocompatibility, making them potentially useful for orthopedic and dental implants.

NANOMATERIALS (2021)

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Article Materials Science, Biomaterials

Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties

Marijana R. Pantovic Pavlovic et al.

Summary: The study investigates the corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) composite coatings on titanium substrate with and without chitosan oligosaccharide lactate (ChOL). Results show that ACP + ChOL/TiO2 coating exhibits better corrosion stability, bioactivity, and antibacterial activity compared to ACP/TiO2 coating. The mechanism behind the antibacterial activity is believed to involve ChOL binding with bacterial cell walls, altering membrane permeability, and leading to bacterial death.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Abhishek Tiwari et al.

Summary: Surface treatment of metallic implants is crucial in orthopedics and orthodontics to prevent bacterial infections, and using coating processes can reduce bacterial and biofilm adhesion, lowering the risk of infection and providing a solution to reduce medical expenses.

COATINGS (2021)

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Review Infectious Diseases

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Mariam Rima et al.

Summary: Antimicrobial peptides are a promising alternative to antibiotics for treating bacterial infections, especially those caused by multidrug-resistant pathogens. They show various activity spectra and mechanisms of actions, and can be used synergistically against ESKAPE bacteria, particularly in biofilm treatments. Challenges and limitations in their therapeutic applications are highlighted, with potential solutions being evaluated to determine if antimicrobial peptides could potentially replace antibiotics in the future.

ANTIBIOTICS-BASEL (2021)

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Article Chemistry, Physical

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Jianghong Luo et al.

Summary: In this study, a pulse electrochemical method was used to introduce polypyrrole into hydroxyapatite coatings on titanium surfaces, creating nanocomposite coatings with superior bioactivity and antibacterial properties, achieving 100% antibacterial rates against Staphylococcus aureus and Escherichia coli. Among these coatings, the PPy@HA/ZnO-Ag composite demonstrated excellent abilities in promoting cell growth and proliferation, making it an ideal implant coating with the best osteoinductive capacity.

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Viviane Staendert et al.

Summary: The study demonstrates the creation of a mechanically stable porous structure on a titanium surface and embedding of silver particles to enhance osteointegration and provide antibacterial properties through preoperative loading of antibiotics. The novel surface modification shows good biocompatibility, antibacterial effects, and support for osteointegration without negative impact of the released drug.

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Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration

Lai-jie Wang et al.

Summary: Titanium alloys are popular research topics in the field of medical metal implants due to their excellent mechanical properties and biocompatibility. Surface biological inertness is a challenge that titanium alloys must overcome, and surface modification can improve the biological properties. The microporous copper-titanium dioxide coating can promote the osseointegration of titanium implants both in vitro and in vivo.

NANOSCALE RESEARCH LETTERS (2021)

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Multifunctional Titanium Surfaces for Orthopedic Implants: Antimicrobial Activity and Enhanced Osseointegration

Fiorela Ghilini et al.

Summary: This study developed a simple method for multifunctional coating on titanium surfaces, combining antibacterial silver nanoparticles and regenerative properties of lactoferrin to address both infection and osseointegration issues. The results showed improved cell adhesion, proliferation, and differentiation, along with a significant reduction in bacterial colonization.

ACS APPLIED BIO MATERIALS (2021)

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Article Nanoscience & Nanotechnology

In Vitro Bioactivity and Antibacterial Activity of Strontium-, Magnesium-, and Zinc-Multidoped Hydroxyapatite Porous Coatings Applied via Atmospheric Plasma Spraying

Yu-Cheng Liu et al.

Summary: The study synthesized HAp powder using different methods and prepared HAp coatings doped with different elements, with promising results showing the potential of ZnSrMg-HAp as a coating for biomedical materials, reducing bacterial infection and enhancing osseointegration.

ACS APPLIED BIO MATERIALS (2021)

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Article Engineering, Biomedical

Multifunctional calcium phosphate based coatings on titanium implants with integrated trace elements

C. Wolf-Brandstetter et al.

BIOMEDICAL MATERIALS (2020)

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MATERIALS LETTERS (2020)

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A functionalized Sm/Sr doped TiO2 nanotube array on titanium implant enables exceptional bone-implant integration and also self-antibacterial activity

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Gabriela Ciobanu et al.

CERAMICS INTERNATIONAL (2019)

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Surface functionalization of titanium with zinc/strontium-doped titanium dioxide microporous coating via microarc oxidation

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Engineering, Biomedical

Mechanical and biological properties of ZnO, SiO2, and Ag2O doped plasma sprayed hydroxyapatite coating for orthopaedic and dental applications

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ACTA BIOMATERIALIA (2019)

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Article Medicine, General & Internal

Postoperative pain management and opioids 1 Transition from acute to chronic pain after surgery

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LANCET (2019)

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Article Biotechnology & Applied Microbiology

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Wen-qing Zhu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Engineering, Biomedical

3-D printed Ti-6Al-4V scaffolds for supporting osteoblast and restricting bacterial functions without using drugs: Predictive equations and experiments

Nicole J. Bassous et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Biomedical

Efficacy of eluted antibiotics through 3D printed femoral implants

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BIOMEDICAL MICRODEVICES (2019)

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Review Biotechnology & Applied Microbiology

Titanium-Tissue Interface Reaction and Its Control With Surface Treatment

Takao Hanawa

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Bismuth-Doped Nanohydroxyapatite Coatings on Titanium Implants for Improved Radiopacity and Antimicrobial Activity

Gabriela Ciobanu et al.

NANOMATERIALS (2019)

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Article Orthopedics

Iodine-supported titanium implants have good antimicrobial attachment effects

Daisuke Inoue et al.

JOURNAL OF ORTHOPAEDIC SCIENCE (2019)

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Article Materials Science, Biomaterials

The effect of hybrid coatings based on hydrogel, biopolymer and inorganic components on the corrosion behavior of titanium bone implants

Mariia Saveleva et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Materials Science, Multidisciplinary

Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm

Junjie Dong et al.

MATERIALIA (2019)

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Article Public, Environmental & Occupational Health

Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index

Eili Y. Klein et al.

BMJ GLOBAL HEALTH (2019)

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Review Engineering, Biomedical

Three-dimensional printing of metals for biomedical applications

J. Ni et al.

MATERIALS TODAY BIO (2019)

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Article Chemistry, Physical

Antibacterial effect of zinc oxide/hydroxyapatite coatings prepared by chemical solution deposition

Naofumi Ohtsu et al.

APPLIED SURFACE SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Antimicrobial and Antifouling Polymeric Agents for Surface Functionalization of Medical Implants

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BIOMACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Chitosan nanoparticles and povidone iodine containing alginate gel for prevention and treatment of orthopedic implant associated infections

Vaishali Pawar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Materials Science, Biomaterials

Anodised TiO2 nanotubes as a scaffold for antibacterial silver nanoparticles on titanium implants

Urvashi Fowdar Gunputh et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Microbiology

Implant infections: adhesion, biofilm formation and immune evasion

Carla Renata Arciola et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Article Chemistry, Applied

Tailoring the surface characteristics of electrophoretically deposited chitosan-based bioactive glass composite coatings on titanium implants via grit blasting

Egemen Avcu et al.

PROGRESS IN ORGANIC COATINGS (2018)

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Article Materials Science, Coatings & Films

Bioactive Zn-doped hydroxyapatite coatings and their antibacterial efficacy against Escherichia coli and Staphylococcus aureus

Rachele Sergi et al.

SURFACE & COATINGS TECHNOLOGY (2018)

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Article Materials Science, Coatings & Films

Characterization of sol-gel derived silver/fluor-hydroxyapatite composite coatings on titanium substrate

Keynoosh Batebi et al.

SURFACE & COATINGS TECHNOLOGY (2018)

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Article Materials Science, Biomaterials

Gentamicin-Loaded Bioactive Hydroxyapatite/Chitosan Composite Coating Electrodeposited on Titanium

Milena Stevanovic et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Dentistry, Oral Surgery & Medicine

Osseointegration and foreign body reaction: Titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation

Ricardo Trindade et al.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH (2018)

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Review Chemistry, Physical

Advances in the induction of osteogenesis by zinc surface modification based on titanium alloy substrates for medical implants

Chaohua Gao et al.

JOURNAL OF ALLOYS AND COMPOUNDS (2017)

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Article Materials Science, Biomaterials

Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon

Francesca Veronesi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Orthopedics

Combined use of intravenous and topical versus intravenous tranexamic acid in primary total knee and hip arthroplasty: a meta-analysis of randomised controlled trials

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2017)

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Review Chemistry, Physical

Additive Manufacturing Processes: Selective Laser Melting, Electron Beam Melting and Binder JettingSelection Guidelines

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MATERIALS (2017)

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Review Dentistry, Oral Surgery & Medicine

Health, Maintenance, and Recovery of Soft Tissues around Implants

Yulan Wang et al.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH (2016)

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Article Engineering, Biomedical

Gentamicin coating of plasma chemical oxidized titanium alloy prevents implant-related osteomyelitis in rats

M. Diefenbeck et al.

BIOMATERIALS (2016)

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Article Materials Science, Multidisciplinary

Osteoimmunomodulation for the development of advanced bone biomaterials

Zetao Chen et al.

MATERIALS TODAY (2016)

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Article Multidisciplinary Sciences

Silver-nanoparticles-modified biomaterial surface resistant to staphylococcus: new insight into the antimicrobial action of silver

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SCIENTIFIC REPORTS (2016)

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Review Biotechnology & Applied Microbiology

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects

Mahendra Rai et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

Antibiotic resistance in human peri-implantitis microbiota

Thomas E. Rams et al.

CLINICAL ORAL IMPLANTS RESEARCH (2014)

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Review Biotechnology & Applied Microbiology

Polymers for medical and tissue engineering applications

Deniz Ozdil et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2014)

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Article Materials Science, Biomaterials

Strategies to prepare TiO2 thin films, doped with transition metal ions, that exhibit specific physicochemical properties to support osteoblast cell adhesion and proliferation

Marshal Dhayal et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2014)

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Article Materials Science, Biomaterials

Effect of copper (Cu2+) inclusion on the bioactivity and antibacterial behavior of calcium silicate coatings on titanium metal

S. Kalaivani et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Review Multidisciplinary Sciences

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

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JOURNAL OF THE ROYAL SOCIETY INTERFACE (2012)

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Article Toxicology

Toxicity of silver nanoparticles-Nanoparticle or silver ion?

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TOXICOLOGY LETTERS (2012)

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Article Chemistry, Multidisciplinary

The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range

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RSC ADVANCES (2012)

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Review Microbiology

Scenery of Staphylococcus implant infections in orthopedics

Lucio Montanaro et al.

FUTURE MICROBIOLOGY (2011)

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Article Engineering, Biomedical

Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use

Davide Campoccia et al.

BIOMATERIALS (2010)

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Review Dentistry, Oral Surgery & Medicine

Biofilm Formation on Dental Restorative and Implant Materials

H. J. Busscher et al.

JOURNAL OF DENTAL RESEARCH (2010)

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Review Engineering, Biomedical

Antibacterial Coatings on Titanium Implants

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2009)

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Article Dentistry, Oral Surgery & Medicine

Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients

Alberto Sicilia et al.

CLINICAL ORAL IMPLANTS RESEARCH (2008)

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Article Computer Science, Information Systems

Healthy aims: Development new medical implants and diagnostic equipment

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IEEE PERVASIVE COMPUTING (2008)

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Article Engineering, Biomedical

Surface chemistry influences implant-mediated host tissue responses

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

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SUSPECTED ASSOCIATION OF AN ALLERGIC REACTION WITH TITANIUM DENTAL IMPLANTS: A CLINICAL REPORT

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Article Dentistry, Oral Surgery & Medicine

Infection at titanium implants with or without a clinical diagnosis of inflammation

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CLINICAL ORAL IMPLANTS RESEARCH (2007)

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Review Engineering, Biomedical

Implant infection and infection resistant materials: A mini review

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INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2005)

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Review Public, Environmental & Occupational Health

Implant infections: a haven for opportunistic bacteria

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JOURNAL OF HOSPITAL INFECTION (2001)

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