4.6 Review

Immunotherapy in oncology and the kidneys: a clinical review of the evaluation and management of kidney immune-related adverse events

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Transplantation

AA amyloidosis associated with cancers

Joyita Bharati et al.

Summary: Systemic AA amyloidosis is associated with autoimmune disorders, chronic infections, and malignant tumors such as renal cell carcinoma. Lung cancer and basal cell carcinoma skin are also often reported with AA amyloidosis. The immune response from the tumor or immune therapy may contribute to the association between cancer and AA amyloidosis. Treatment involves targeting the underlying malignancy or discontinuing the offending agent.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Review Urology & Nephrology

Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy

Nupur N. Uppal et al.

Summary: Novel immunotherapy drugs have revolutionized cancer medicine, but they can also lead to immune-related adverse events, including electrolyte disorders. This review examines the associated electrolyte disorders, such as hyponatremia, hypokalemia, hypercalcemia, hypocalcemia, and hyperphosphatemia. Early recognition and prompt diagnosis are crucial for managing these novel electrolyte disorders.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Review Transplantation

Immune checkpoint inhibitor-associated hypercalcaemia

Hassan Izzedine et al.

Summary: Immune checkpoint inhibitors (CPIs) are important for treating advanced cancers, but they can also cause immune-related adverse events (irAEs), including hypercalcemia. The causes of CPI-induced hypercalcemia may include endocrine diseases, granulomas, hormonal imbalances, and disease progression. Early recognition and treatment of hypercalcemia are crucial for patient outcomes.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Review Oncology

Immune Checkpoint Inhibitor Rechallenge After Prior Immune Toxicity

Sophia Bylsma et al.

Summary: Immune checkpoint inhibitors (ICIs) have become crucial in the treatment of many cancer types, but they also bring about a new form of drug toxicity called immune-related adverse events (irAEs). irAEs are common and can have serious consequences, leading to treatment discontinuation and adverse outcomes for patients. However, with careful consideration and appropriate patient selection, resuming treatment with ICIs can be a reasonable approach.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

Article Oncology

Immune checkpoint inhibitors in kidney transplant recipients: a multicentre, single-arm, phase 1 study

Robert P. Carroll et al.

Summary: Maintaining baseline immunosuppression before treatment with an immune checkpoint inhibitor in kidney transplant recipients might not affect expected efficacy and might reduce the risk of allograft rejection mediated by immune checkpoint inhibitors.

LANCET ONCOLOGY (2022)

Editorial Material Urology & Nephrology

Acute Interstitial Nephritis on Positron-Emission Tomography-Computed Tomography Imaging

Jing Miao et al.

KIDNEY MEDICINE (2022)

Article Urology & Nephrology

Acute interstitial nephritis associated with immune checkpoint inhibitors: a single-centre experience

Diana Oleas et al.

Summary: This study highlights the occurrence of AIN in patients with solid organ metastatic malignancies treated with CPIs, with the kidney being a commonly affected organ. The majority of patients showed improvement in kidney function with steroid treatment, indicating a favorable response to this type of toxicity.

CLINICAL KIDNEY JOURNAL (2021)

Article Oncology

Incidence and Prediction of Immune Checkpoint Inhibitor-related Nephrotoxicity

Jonathan D. Sorah et al.

Summary: This study investigated the incidence and predictive factors of immune-related acute kidney injury (irAKI) caused by ICIs. It found that a history of autoimmune disease and other immune-related adverse events (irAEs) were associated with irAKI, highlighting the importance of early recognition and steroid administration for a positive outcome.

JOURNAL OF IMMUNOTHERAPY (2021)

Review Urology & Nephrology

A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease

Abhijat Kitchlu et al.

Summary: This study summarized the association between immune checkpoint inhibitors and glomerular diseases, revealing various forms of diseases including pauci-immune glomerulonephritis, podocytopathies, and C3GN. Most patients experienced complete or partial recovery from acute kidney injury, but a portion of patients still required dialysis.

KIDNEY INTERNATIONAL REPORTS (2021)

Article Urology & Nephrology

A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Naoka Murakami et al.

Summary: Immune checkpoint inhibitors pose a high risk of acute rejection in kidney transplant patients but may lead to improved cancer outcomes. Prospective studies are needed to determine optimal immunosuppression strategies to improve patient outcomes.

KIDNEY INTERNATIONAL (2021)

Article Oncology

Immune-related adverse events and kidney function decline in patients with genitourinary cancers treated with immune checkpoint inhibitors

Harish Seethapathy et al.

Summary: This study investigated the impact of immune checkpoint inhibitors on kidney function in patients with renal cell carcinoma and urothelial carcinoma. The results showed that acute kidney injury and sustained eGFR loss were common, and immune-related adverse events may be a novel risk factor for kidney function decline in patients receiving ICIs.

EUROPEAN JOURNAL OF CANCER (2021)

Article Transplantation

Hyponatremia and other electrolyte abnormalities in patients receiving immune checkpoint inhibitors

Harish Seethapathy et al.

Summary: Hyponatremia is common in cancer patients receiving ICIs, but endocrinopathies are not a common cause of severe hyponatremia. Other severe electrolyte abnormalities are also commonly observed.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Review Urology & Nephrology

KDIGO 2021 CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF GLOMERULAR DISEASES

Brad H. Rovin et al.

Summary: The KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases aims to assist clinicians caring for individuals with glomerular disease by providing actionable recommendations and valuable infographics. It also proposes research recommendations for areas where there are gaps in knowledge, targeting a broad audience of clinicians treating glomerular disease. The guideline development process followed an explicit evidence review and the treatment approaches are based on systematic reviews, evidence synthesis, and the GRADE approach.

KIDNEY INTERNATIONAL (2021)

Article Urology & Nephrology

Biomarkers, Clinical Features, and Rechallenge for Immune Checkpoint Inhibitor Renal Immune-Related Adverse Events

Busra Isik et al.

Summary: This study found that at the time of AKI, ICI-AKI patients had significantly higher SCr, CRP, and uRBP/Cr levels compared to non-ICI-AKI patients. The time from ICI initiation to AKI was shorter in the ICI-AKI group compared to the referent group. Among the ICI-AKI group, 39% of patients achieved complete renal recovery within 3 months.

KIDNEY INTERNATIONAL REPORTS (2021)

Article Oncology

Renal adverse effects of immune checkpoints inhibitors in clinical practice: ImmuNoTox study

M. Espi et al.

Summary: A retrospective analysis of patients undergoing checkpoint inhibitor therapy revealed a 3.7% incidence of CPI-induced AKI, primarily acute tubulointerstitial nephritis with mild severity. Despite a higher occurrence of other IRAEs in these patients, it was not associated with an increased risk of AKI.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

Acute kidney injury in patients treated with immune checkpoint inhibitors

Shruti Gupta et al.

Summary: Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) is an important toxicity among cancer patients. Impaired renal function at baseline, PPI use, and extrarenal irAEs were associated with a higher risk of ICPi-AKI. Two-thirds of patients experienced renal recovery following ICPi-AKI, with corticosteroid treatment associated with improved recovery.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Rapid corticosteroid taper versus standard of care for immune checkpoint inhibitor induced nephritis: a single-center retrospective cohort study

Meghan D. Lee et al.

Summary: Treatment with a rapid corticosteroid taper in patients with ICI-induced nephritis leads to excellent kidney outcomes, but there was no significant difference in time to renal recovery between the rapid-taper group and the standard-of-care group.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Immune adverse events (irAEs) with adjuvant ipilimumab in melanoma, use of immunosuppressants and association with outcome: ECOG-ACRIN E1609 study analysis

Ahmad A. Tarhini et al.

Summary: The impact of immune-related adverse events (irAEs) on the use of immunotherapy and their management on relapse-free survival (RFS) and overall survival (OS) outcomes is not well understood. Patients experiencing grades 1-2 irAEs had better RFS and OS outcomes compared to those with no AE, with rash and endocrine irAEs being the most significant factors. Higher grade irAEs had less benefits, and use of corticosteroids and immunosuppressants did not significantly affect RFS or OS outcomes.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Urology & Nephrology

Immune checkpoint inhibitor use in patients with end-stage kidney disease: an analysis of reported cases and literature review

Abhijat Kitchlu et al.

Summary: ICI therapy has substantially improved prognosis of patients with advanced malignancy, with similar incidence of immune-related adverse events in ESKD patients compared with the general population. Severe reactions have been seen in some cases, but cancer remission was observed in close to 30% of patients. More data from prospective studies are needed to assess outcomes more accurately.

CLINICAL KIDNEY JOURNAL (2021)

Article Oncology

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

Julie R. Brahmer et al.

Summary: ICIs are standard treatments for cancer, but come with risks of immune-related adverse events. The SITC convened an expert panel to develop guidelines for managing irAEs, aiming to improve patient outcomes through evidence-based recommendations.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

Comparative Risk of Renal Adverse Events in Patients Receiving Immune Checkpoint Inhibitors: A Bayesian Network Meta-Analysis

Kang Liu et al.

Summary: The study analyzed 95 eligible randomized controlled trials involving 40,552 participants and found that both ICI-based regimens and traditional cancer therapies had a higher risk of RAEs and AKI compared to placebo. Among the various ICI therapies, anti-CTLA-4 appeared to be associated with increased toxicity, while anti-PD-1 was safer.

FRONTIERS IN ONCOLOGY (2021)

Editorial Material Urology & Nephrology

A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation

Xavier Charmetant et al.

CLINICAL KIDNEY JOURNAL (2020)

Review Urology & Nephrology

Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do?

Mark A. Perazella et al.

KIDNEY INTERNATIONAL (2020)

Article Urology & Nephrology

Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study

Frank B. Cortazar et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Medicine, General & Internal

Acute hyponatremia from immune checkpoint inhibitor therapy for non-small cell lung cancer

Sai Prasad Desikan et al.

POSTGRADUATE MEDICAL JOURNAL (2020)

Article Urology & Nephrology

Safety and Efficacy of Immune Checkpoint Inhibitors in Patients on Dialysis: A Retrospective Case Series

Ian A. Strohbehn et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

Review Cell Biology

Immune checkpoint signaling and cancer immunotherapy

Xing He et al.

CELL RESEARCH (2020)

Article Oncology

Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes

Alejandro Meraz-Munoz et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Urology & Nephrology

Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events

Sandra M. Herrmann et al.

KIDNEY INTERNATIONAL REPORTS (2020)

Review Urology & Nephrology

Hyponatremia in the cancer patient

Biruh T. Workeneh et al.

KIDNEY INTERNATIONAL (2020)

Article Multidisciplinary Sciences

A decade of immune-checkpoint inhibitors in cancer therapy

Caroline Robert

NATURE COMMUNICATIONS (2020)

Article Oncology

Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-Based Cohort Study

Abhijat Kitchlu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

Maddalena Centanni et al.

CLINICAL PHARMACOKINETICS (2019)

Review Medicine, General & Internal

Immune checkpoint inhibitor-induced colitis: A comprehensive review

Aniruddh Som et al.

WORLD JOURNAL OF CLINICAL CASES (2019)

Article Oncology

C-reactive protein as an early marker of immune-related adverse events

Amir-Reza Abolhassani et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Article Urology & Nephrology

The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors

Harish Seethapathy et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Multidisciplinary Sciences

Risk factors for immune-related adverse events associated with anti-PD-1 pembrolizumab

Yeonghee Eun et al.

SCIENTIFIC REPORTS (2019)

Article Oncology

Immune dysregulation in cancer patients developing immune-related adverse events

Shaheen Khan et al.

BRITISH JOURNAL OF CANCER (2019)

Article Urology & Nephrology

Renal toxicities associated with pembrolizumab

Hassan Izzedine et al.

CLINICAL KIDNEY JOURNAL (2019)

Article Oncology

Correlation between blood cell count and outcome of melanoma patients treated with anti-PD-1 antibodies

Yoshiyuki Nakamura et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Urology & Nephrology

Anti - PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1

Clarissa Cassol et al.

KIDNEY INTERNATIONAL REPORTS (2019)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Article Medicine, General & Internal

IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma

Seiji Kishi et al.

INTERNAL MEDICINE (2018)

Letter Medicine, General & Internal

Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy

Abhijat Kitchlu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Oncology

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy

Xiaolei Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Medicine, Research & Experimental

Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade

Sara Valpione et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Article Surgery

Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients

Ouidad Zehou et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

Review Urology & Nephrology

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Rimda Wanchoo et al.

AMERICAN JOURNAL OF NEPHROLOGY (2017)

Article Urology & Nephrology

Association of Acute Interstitial Nephritis With Programmed Cell Death 1 Inhibitor Therapy in Lung Cancer Patients

Anushree C. Shirali et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2016)

Letter Surgery

Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection

T. Alhamad et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

Review Endocrinology & Metabolism

Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: clinical review

M. N. Joshi et al.

CLINICAL ENDOCRINOLOGY (2016)

Article Urology & Nephrology

Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors

Frank B. Cortazar et al.

KIDNEY INTERNATIONAL (2016)

Letter Medicine, General & Internal

Tumor Regression and Allograft Rejection after Administration of Anti-PD-1

Evan J. Lipson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Pharmacology & Pharmacy

Ipilimumab Granulomatous Interstitial Nephritis

Bijin Thajudeen et al.

AMERICAN JOURNAL OF THERAPEUTICS (2013)

Review Urology & Nephrology

Chronic kidney disease following acute kidney injury-risk and outcomes

Kelvin C. W. Leung et al.

NATURE REVIEWS NEPHROLOGY (2013)

Article Oncology

Management of Immune-Related Adverse Events and Kinetics of Response With Ipilimumab

Jeffrey S. Weber et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Article Urology & Nephrology

Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury

Ion D. Bucaloiu et al.

KIDNEY INTERNATIONAL (2012)

Article Oncology

Hyponatremia associated with Ipilimumab-induced hypophysitis

Zachary R. Barnard et al.

MEDICAL ONCOLOGY (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

Ron J. Keizer et al.

CLINICAL PHARMACOKINETICS (2010)

Article Urology & Nephrology

Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

Steven G. Coca et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2009)

Letter Medicine, General & Internal

Anti-CTLA4 Antibody-Induced Lupus Nephritis.

Fouad Fadel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

FDG-PET of patients with suspected renal failure: standardized uptake values in normal tissues

Ryogo Minamimoto et al.

ANNALS OF NUCLEAR MEDICINE (2007)

Review Cell Biology

Receptor downregulation and multivesicular-body sorting

DJ Katzmann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)