期刊
CELL METABOLISM
卷 22, 期 3, 页码 408-417出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.06.011
关键词
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资金
- Swedish Diabetes Association
- Swedish Cancer Foundation
- Swedish Research Council
- Novo Nordisk Foundation
- EFSD Lilly European Diabetes Research Programme
- CIMED
- ERC
- Diabetes Program at the Karolinska Institutet
- Human Frontiers Long-Term Fellowship [LT000231/2011-L]
- Novo Nordisk Fonden [NNF12OC1016371, NNF14OC0010187, NNF12OC1016064] Funding Source: researchfish
Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute similar to 10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.
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