UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

Article Plant Sciences

A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization

Javier Palacios et al.

Summary: The plant Senecio nutans SCh. Bip. is used by Andean communities to treat altitude sickness. Recent evidence suggests it may produce vasodilation and negative cardiac inotropy, though the cellular mechanisms have not been elucidated.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Chemistry, Applied

Analysis of the binding selectivity and inhibiting mechanism of chlorogenic acid isomers and their interaction with grass carp endogenous lipase using multi-spectroscopic, inhibition kinetics and modeling methods

Zeru Xu et al.

Summary: Polyphenols, specifically chlorogenic acid isomers, have inhibitory effects on lipase. The study found that neochlorogenic acid had better inhibitory effect than cryptochlorogenic acid, and electrostatic interaction force played a major role in the lipase-cryptochlorogenic acid system. Molecular dynamics studies showed that neochlorogenic acid had a greater impact on the lipase structure.

FOOD CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Exploring the Extraction Methods of Phenolic Compounds in Daylily (Hemerocallis citrina Baroni) and Its Antioxidant Activity

Zhilin Hao et al.

Summary: Daylily is a valuable plant resource with various health benefits. In this study, four extraction methods were compared for their effectiveness in extracting phenolic compounds from daylily. The ultrasonic-assisted ethanol extraction method showed the highest total phenolic content and the best antioxidant activity. A total of 26 phenolic compounds were identified, with the ultrasonic-assisted ethanol extract showing a higher abundance of phenolic compounds. These results provide theoretical support for the extraction of phenolic compounds from daylily and its application as a functional food.

MOLECULES (2022)

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Article Cell Biology

HPLC-PDA-ESI-HRMS-Based Profiling of Secondary Metabolites of Rindera graeca Anatomical and Hairy Roots Treated with Drought and Cold Stress

Marcin Robert Naliwajski et al.

Summary: To cope with environmental harmful conditions, plant cells developed adaptive strategies by producing complex secondary metabolites. In this study, the root cultures of Rindera graeca were exposed to abiotic stresses, and the highest number of phytochemicals was found in roots subjected to coldness. Lithospermic B acid was identified as the most abundant compound in all root extracts. Therefore, root cultures of R. graeca can serve as a new and abundant source of lithospermic B acid.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Metabolomic Profiling, Antioxidant and Enzyme Inhibition Properties and Molecular Docking Analysis of Antarctic Lichens

Alfredo Torres-Benitez et al.

Summary: This study reports the chemical composition, antioxidant and cholinesterase enzyme inhibitory activity, and molecular docking analysis of three lichen species found in the Antarctic territory. The results show that these species contain different compounds and exhibit high inhibition potential on the cholinesterase enzymes. The study provides evidence for the chemical fingerprint of these lichens and supports further research on their other biological activities and potential for medical research.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Phenolic Fingerprinting and Bioactivity Profiling of Extracts and Isolated Compounds from Gypothamnium pinifolium Phil.

Ruth E. Barrientos et al.

Summary: This preliminary study investigated the phenolic composition, antioxidant activity, relaxation effects, enzyme inhibition potential, and antiproliferative activity of Gypothamnium pinifolium Phil. from Chile. The results showed that G. pinifolium is a valuable source of secondary metabolites with potential activity against noncommunicable diseases.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

A physiologically relevant role for NO stored in vascular smooth muscle cells: A novel theory of vascular NO signaling

Taiming Liu et al.

Summary: This review proposes a classification of compounds called "nitrodilators" that dilate vessels by activating a preformed nitrodilator-activated NO store (NANOS) within the cell, despite not releasing free NO.

REDOX BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities of Himantormia lugubris from Antarctica

Carlos Areche et al.

Summary: In this study, the metabolite fingerprinting, antioxidant, and enzyme inhibitory potential of Himantormia lugubris, a small lichen shrub native to Chile and growing in the Antarctica region, were investigated for the first time. The results showed that this species is a rich source of bioactive compounds with good inhibition activity against cholinesterase and tyrosinase enzymes, as well as potential antioxidant activity.

METABOLITES (2022)

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Article Biochemistry & Molecular Biology

Antioxidant, Antiproliferative and Anti-Enzymatic Capacities, Nutritional Analysis and UHPLC-PDA-MS Characterization of Ungurahui Palm Fruits (Oenocarpus bataua Mart) from the Peruvian Amazon

Gabriel Vargas-Arana et al.

Summary: In this study, nine natural populations of ungurahui from the Peruvian Amazon were analyzed for their nutritional and biological activities. UHPLC-MS analysis revealed the presence of 24 compounds with antioxidant and cholinesterase inhibition activities. The differences among populations may be attributed to the different growing conditions of ungurahui. The fruit of the ungurahui palm tree is a good natural source of antioxidants and dietary fatty acids, which can be used for the prevention of neurodegenerative or related non-chronic transmittable diseases.

ANTIOXIDANTS (2022)

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Article Chemistry, Analytical

Evaluation of Pulsed Electric Field-Assisted Extraction on the Microstructure and Recovery of Nutrients and Bioactive Compounds from Mushroom (Agaricus bisporus)

Mara Calleja-Gomez et al.

Summary: Pulsed electric field (PEF) is a sustainable technology for extracting nutrients and bioactive compounds from vegetables. This study found that PEF pretreatment can significantly increase the recovery of phenolic compounds, carbohydrates, proteins, and minerals from mushrooms.

SEPARATIONS (2022)

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Review Nutrition & Dietetics

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Umair Shabbir et al.

Summary: Polyphenols are naturally occurring bioactive components in fruits and vegetables, playing a role in improving metabolic syndromes and preventing chronic diseases by influencing the composition of gut microbiota. Various approaches have been developed to improve the bioavailability of polyphenols in the gut.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Antihyperlipidemic and Antioxidant Capacities, Nutritional Analysis and UHPLC-PDA-MS Characterization of Cocona Fruits (Solanum sessiliflorum Dunal) from the Peruvian Amazon

Gabriel Vargas-Arana et al.

Summary: Cocona fruits are popular food and medicinal fruits in South America, with high nutritional and antioxidant values that help lower cholesterol and triglyceride levels, preventing atherosclerosis.

ANTIOXIDANTS (2021)

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Review Pharmacology & Pharmacy

Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic

Mahdi Balali-Mood et al.

Summary: Industrial activities of the last century have led to increased human exposure to heavy metals such as mercury, lead, chromium, cadmium, and arsenic, resulting in acute or chronic poisonings through water, air, and food. These heavy metals accumulate in the body, causing toxic effects on various tissues and organs by disrupting cellular events and inducing oxidative stress. Common mechanisms of action of these metals include ROS generation, inhibition of antioxidant defense, enzyme inactivation, and selective binding to specific macromolecules, some leading to genomic instability and carcinogenicity through DNA damage and oxidative stress. Despite current knowledge, heavy metal poisoning incidents remain prevalent, necessitating preventive measures and effective treatment, possibly including chelation therapy.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy

Fei Tang et al.

Summary: This study highlights the importance of traditional Chinese medicine and natural products in the prevention and treatment of cardiovascular and cerebrovascular diseases, providing comprehensive references on hypertension and CCVDs, and emphasizing the different mechanisms of action of traditional Chinese medicine and natural products.

FRONTIERS IN PHARMACOLOGY (2021)

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Article

Constituents of Endodesmia calophylloides Benth. and Adenia lobata (Jacq.) Engl. with antileihsmanial activities

Jean Garba Koffi et al.

Chemical Data Collections (2021)

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Article Biochemistry & Molecular Biology

UHPLC-MS Chemical Fingerprinting and Antioxidant, Antiproliferative, and Enzyme Inhibition Potential of Gaultheria pumila Berries

Carlos Fernandez-Galleguillos et al.

Summary: Gaultheria pumila berries contain multiple bioactive metabolites with antioxidant and enzyme inhibition activities. They show moderate inhibitory effects against acetylcholinesterase, butyrylcholinesterase, and tyrosinase enzymes, but have weak antiproliferative potential against several solid human cancer cells.

METABOLITES (2021)

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Article Biochemistry & Molecular Biology

Proximal Composition ofUndaria pinnatifidafrom San Jorge Gulf (Patagonia, Argentina)

Vanesa N. Salomone et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Article Food Science & Technology

Inhibition of porcine pancreatic α-amylase activity by chlorogenic acid

Yuxue Zheng et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Nutrition & Dietetics

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Anne-Laure Tardy et al.

NUTRIENTS (2020)

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Article Pharmacology & Pharmacy

Metabolomic Analysis, Fast Isolation of Phenolic Compounds, and Evaluation of Biological Activities of the Bark From Weinmannia trichosperma Cav. (Cunoniaceae)

Ruth Barrientos et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Agriculture, Multidisciplinary

Characterization and Quantification of Nonanthocyanin Phenolic Compounds in White and Blue Bilberry (Vaccinium myrtillus) Juices and Wines Using UHPLC-DAD-ESI-QTOF-MS and UHPLC-DAD

Shuxun Liu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effect of Antioxidants in the Brain

Kyung Hee Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Chemical Fingerprinting and Biological Evaluation of the Endemic Chilean FruitGreigia sphacelata(Ruiz and Pav.) Regel (Bromeliaceae) by UHPLC-PDA-Orbitrap-Mass Spectrometry

Ruth E. Barrientos et al.

MOLECULES (2020)

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Article Pharmacology & Pharmacy

Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae)

Maria Jose Larrazabal-Fuentes et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biology

Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties

Constanza Sabando et al.

BIOLOGICAL RESEARCH (2020)

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Article Food Science & Technology

Evaluation of the Bioaccessibility of Antioxidant Bioactive Compounds and Minerals of Four Genotypes of Brassicaceae Microgreens

Beatriz de la Fuente et al.

FOODS (2019)

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Article Food Science & Technology

Bioactive polyphenols and antioxidant capacity of Azara petiolaris and Azara integrifolia Honeys

Ady Giordano et al.

CYTA-JOURNAL OF FOOD (2018)

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Article Food Science & Technology

UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation

Andrei Mocan et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

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Article Food Science & Technology

UHPLC-ESI-QTOF-MS profile of polyphenols in Goji berries (Lycium barbarum L.) and its dynamics during in vitro gastrointestinal digestion and fermentation

Gabriele Rocchetti et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Food Science & Technology

Bioactive polyphenols and antioxidant capacity of Azara petiolaris and Azara integrifolia Honeys

Ady Giordano et al.

CYTA-JOURNAL OF FOOD (2018)

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Review Pharmacology & Pharmacy

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Rozita Naseri et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes

Felipe Jimenez-Aspee et al.

MOLECULES (2017)

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Article Pharmacology & Pharmacy

Glycolytic enzyme inhibitory and antiglycation potential of rutin

Shagun Dubey et al.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Plant Sciences

Hydroalcoholic extract and pure compounds from Senecio nutans Sch Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms

Adrian Paredes et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Agriculture, Multidisciplinary

Determination of polyphenolic profile, antioxidant activity and antibacterial properties of maqui [Aristotelia chilensis (Molina) Stuntz] a Chilean blackberry

Estefania Genskowsky et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2016)

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Article Chemistry, Applied

Anthocyanins and antioxidant capacities of six Chilean berries by HPLC-HR-ESI-ToF-MS

Javier E. Ramirez et al.

FOOD CHEMISTRY (2015)

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Article Agricultural Engineering

Phenolic constituent, antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L. from Turkey: A phytochemical study

Gokhan Zengin et al.

INDUSTRIAL CROPS AND PRODUCTS (2015)

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Article Chemistry, Applied

Antioxidant capacity, polyphenolic content and tandem HPLC-DAD-ESI/MS profiling of phenolic compounds from the South American berries Luma apiculata and L. chequen

Mario J. Simirgiotis et al.

FOOD CHEMISTRY (2013)

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Article Biochemistry & Molecular Biology

Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer's Disease and Some Pro-oxidant Induced Oxidative Stress in Rats' Brain-In Vitro

Ganiyu Oboh et al.

NEUROCHEMICAL RESEARCH (2013)

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Article Neurosciences

Targeting Parkinson’s - Tyrosine Hydroxylase and Oxidative Stress as Points of Interventions

Mohd Shahnawaz Khan et al.

CNS & Neurological Disorders-Drug Targets (2012)

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Article Environmental Sciences

Mineral and heavy metal contents of the outer and inner tissues of commonly used fruits

Mehmet Musa Oezcan et al.

ENVIRONMENTAL MONITORING AND ASSESSMENT (2012)

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Article Chemistry, Applied

Berry components inhibit α-glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry

Ashley S. Boath et al.

FOOD CHEMISTRY (2012)

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Article Chemistry, Medicinal

Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

Shuang Liang et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2011)

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Article Chemistry, Applied

Investigation of α-glucosidase inhibitory activity of wheat bran and germ

Lei Liu et al.

FOOD CHEMISTRY (2011)

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Article Agriculture, Multidisciplinary

Berry Polyphenols Inhibit α-Amylase in Vitro: Identifying Active Components in Rowanberry and Raspberry

Dominic Grussu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

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Article Plant Sciences

EFFECT OF DIFFERENT CALCIUM FRUIT CONTENT IN PHYSICAL AND CHEMICAL PROPERTIES OF EUROPEAN PLUM

A. E. Rato et al.

JOURNAL OF PLANT NUTRITION (2010)

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Article Chemistry, Applied

Berry polyphenols inhibit pancreatic lipase activity in vitro

Gordon J. McDougall et al.

FOOD CHEMISTRY (2009)

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Review Environmental Sciences

Heavy metals: Implications associated to fish consumption

M. I. Castro-Gonzalez et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2008)

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Article Plant Sciences

α-amylase inhibitory activity of some Malaysian plants used to treat diabetes;: with particular reference to Phyllanthus amarus

Hasenah Ali et al.

JOURNAL OF ETHNOPHARMACOLOGY (2006)

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Article Biochemical Research Methods

Preparative isolation and purification of syringin and edgeworoside C from Edgeworthia chrysantha Lindl by high-speed counter-current chromatography

JZ Yan et al.

JOURNAL OF CHROMATOGRAPHY A (2004)

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Article Plant Sciences

Free radical scavengers and antioxidants from Baccharis grisebachii

A Tapia et al.

JOURNAL OF ETHNOPHARMACOLOGY (2004)

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Article Agriculture, Multidisciplinary

High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate flourescence reader in 96-well format

DJ Huang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)

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UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

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